TRADE NEWS: Agilent Technologies Microarrays Play Role in Researchers' Study of Autism's Relationship to Extra or Missing Genes

Agilent Technologies today announced that a breakthrough study establishing a relationship between autism spectrum disorders (ASD) and extra or missing genes on a section of chromosome 16 used Agilent microarrays to detect these microdeletions and microduplications.

The study, Association between Microdeletion and Microduplication at 16p11.2 and Autism, published Jan. 9 in The New England Journal of Medicine online, represents the largest, most complete genome scan for ASDs to date. Completed in October, it used three independent data sources. One analysis was conducted by the Autism Consortium, a collaboration of 14 leading universities and medical centers including Childrens Hospital Boston. Another was completed by deCODE Genetics Inc., in Iceland. The third was performed at Childrens Hospital Boston using clinical samples from its own patients.

Researchers screened samples from 936 children from Childrens Hospital Boston using Agilent comparative genomic hybridization (CGH) microarrays. Microarrays are glass slides containing thousands of DNA features that enable scientists to examine large numbers of genes simultaneously. CGH microarrays are designed specifically to detect chromosomal additions and deletions.

The Childrens Hospital team used Agilents online design tool, eArray, to develop custom microarrays for the study. The ability to reliably find extremely small missing or extra pieces of DNA has evolved just within the past six to eight months, noted co-author Yiping Shen, Ph.D., director of Research and Development at the Childrens Genetic Diagnostic Laboratory.

Using Agilent microarrays, Childrens Hospital researchers found five instances of the deletion among 512 patients referred for developmental delay or suspected ASDs. In addition, the Childrens Hospital team identified four patients with a duplication rather than a deletion.

Our findings certainly have the potential for use in evaluating children for development delay and autism, says Bai-Lin Wu, Ph.D., director of the Childrens Hospital Genetic Diagnostic Laboratory, leader of the Childrens team on the study and a senior author of the paper.

Genomics researchers demand tools that give them the freedom to design their own types of experiments, deliver reproducible results and spend fewer dollars per experiment, said Yvonne Linney, Ph.D., vice president and general manager, Genomics, at Agilent. This work is a good example of how far the technology has come.

The full text of the study is available at http://content.nejm.org/cgi/content/full/NEJMoa075974.

More information on autism testing at Childrens Hospital Boston is available at www.childrenshospital.org/clinicalservices/Site1925/ mainpageS1925P9.html. (Due to its length, this URL may need to be copied/pasted into your Internet browser's address field. Remove the extra space if one exists.)

More information about Agilents genomics tools is available at www.opengenomics.com.

About Agilent Technologies

Agilent Technologies Inc. (NYSE:A) is the worlds premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The companys 19,000 employees serve customers in more than 110 countries. Agilent had net revenues of $5.4 billion in fiscal 2007. Information about Agilent is available on the Web at www.agilent.com.

NOTE TO EDITORS: Further technology, corporate citizenship and executive news is available on the Agilent news site at www.agilent.com/go/news.

Contacts:

Agilent Technologies
Stuart Matlow, +1-408-553-7191
stuart_matlow@agilent.com

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