Washington, D.C. 20549




Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.     )



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SCYNEXIS, INC. June 14, 2018 at 9:30 a.m. The Hyatt Regency Jersey City on the Hudson, 2 Exchange Place, Jersey City, NJ COMPANY NUMBER ACCOUNT NUMBER CONTROL NUMBER to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. If you want to receive a paper or e-mail copy of the proxy materials you must request one, otherwise you will not receive a paper or e-mail copy. There is no charge to you for requesting a copy. To facilitate timely delivery, please make the request as instructed below before 5/31/18. Please visit, where the following materials are available for view: Notice of Annual Meeting of Stockholders Proxy Statement 2017 Annual Report Form of Electronic Proxy Card PROXY MATERIALS: E-MAIL: WEBSITE: https://us your .astfinancial online proxy .com/OnlineProxyVoting/ProxyVoting/RequestMaterials card, please visit and follow the on-screen TO VOTE: ONLINE: To access instructions or scan the QR code with your smartphone. You may enter your voting instructions at up until 11:59 PM Eastern Time the day before the cut-off or meeting date. IN PERSON: You may vote your shares in person by attending the Annual Meeting. Directions to the Annual Meeting can be found at the end of the proxy statement or by contacting Investor Relations at MAIL: You may request a proxy card by following the instructions above. to serve until the 2019 Annual Meeting of Stockholders and until their successors are duly elected and qualified. NOMINEES: Steven C. Gilman, Ann F. Hanham, Ph Ph .D..D. David Guy Hastings Macdonald Machado Marion Patrick McCourt Marco Taglietti, M.D. Please note that you cannot use this notice to vote by mail. registered public accounting firm for the fiscal year ending December 31, 2018 THE BOARD OF DIRECTORS RECOMMENDS YOU VOTE “FOR ALL NOMINEES” IN PROPOSAL 1, AND “FOR” PROPOSAL 2