Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will participate in fireside chats at the following investor conferences:

• Raymond James 46^th Annual Institutional Investors Conference on Tuesday, March 4, 2025
• TD Cowen 45^th Annual Health Care Conference on Tuesday, March 4, 2025
• Leerink Partners Global Healthcare Conference 2025 on Tuesday, March 11, 2025
• Barclays 27^th Annual Global Healthcare Conference on Wednesday, March 12, 2025
• UBS Virtual CNS Day 2025 on Monday, March 17, 2025
• Stifel 2025 Virtual CNS Forum on Wednesday, March 19, 2025

A live webcast of these presentations can be accessed on the Investors & Media section of the Ionis website at https://ir.ionis.com/events-and-presentations/upcoming-events. Replays will be available on the Ionis website within 48 hours and will be archived for a limited time.

About Ionis Pharmaceuticals

For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has six marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit Ionis.com and follow us on X (Twitter) and LinkedIn.

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