Spermidine trihydrochloride, also known as Spermidinetrihydrochloride, is a chemical substance with various synonyms, such as spermidine hydrochloride, spermidine trihydrochloride, spermidine HCL, etc. It is a polyamine compound, white crystals at room temperature and pressure, and is often used to release the triamine structure by reacting it with alkali. Spermidine trihydrochloride is mainly used as an intermediate in organic synthesis and a donor in supramolecular chemistry.
Spermidine trihydrochloride is soluble in water and ethanol. Its solubility in water is 1at20°C, and it is transparent and colorless. Spermidine trihydrochloride is an important chemical reagent that can be used to purify DNA-binding proteins and stimulate T4 polynucleotide kinase activity. It can also inhibit neuronal synthases and bind and precipitate DNA.
Spermidine trihydrochloride has certain application value in biology. For example, it is a new type of autophagy inducer that negatively regulates N-methyl-d-aspartate (NMDA) receptors. In addition, spermidine trihydrochloride also plays an important role in plants, such as combating abiotic stresses such as drought and heat stress.
Spermidine trihydrochloride is a polyamine compound with important functions. It is widely present in human cells and various food sources. It plays a vital role in cell function and is known to be involved in processes such as DNA synthesis, protein synthesis and cell growth. Numerous studies have shown that increasing spermidine levels in a variety of organisms (from yeast to mice) can extend lifespan. This compound works by inducing autophagy, a process by which human cells recycle damaged structures and remove harmful waste, thereby rejuvenating cells and improving their overall function.
What are the characteristics of spermidine trihydrochloride?
High purity: high purity products can be obtained through refined production processes, and high purity means better bioavailability and fewer adverse reactions.Safety: It has been proven to be safe for the human body.Stability: It has good stability and can maintain its activity and effect under different environments and storage conditions.
How to get spermidine trihydrochloride?
Spermidine trihydrochloride is widely present in human cells and various food sources. It plays a vital role in cell function and is known to be involved in processes such as DNA synthesis, protein synthesis and cell growth. In addition, foods rich in spermidine include certain types of cheese (such as aged cheese), mushrooms, whole grains, beans and soy products such as tempeh.
Spermidine trihydrochloride can be synthesized by the human body from arginine to ornithine to putrescine to spermidine; it can also be converted from spermine. Maintaining healthy methylation is also important for spermidine synthesis, which requires the participation of dcSAMe, which is derived from SAMe. SAMe is the most important coenzyme in human methylation, and its level is affected by the methylation cycle.
Intake of spermidine precursors can increase spermidine content; both arginine and spermine can have this effect. Foods rich in arginine are mainly nuts, seeds and beans, as well as turkey. Foods rich in spermidine include wheat germ, chicken liver, chicken heart and beef intestines.
It also comes from the synthesis of intestinal flora. Some probiotics can also produce spermidine. The most studied one is Lactococcus lactis LKM512 (Bifidobacterium animalissubsp.lactis LKM512). Some yogurts produced in Japan are added with this strain of bacteria.
What are the effects of spermidine trihydrochloride?
Anti-aging and anti-aging
Spermidine trihydrochloride can effectively repair damaged cells and delay the aging process of cells. Scientists have found that spermidine can stimulate the body's cell autophagy, help repair damaged cells and remove toxic proteins associated with many neurogenic diseases in the body, thereby achieving the effect of delaying aging.
Enhance muscle mass and improve endurance
Spermidine trihydrochloride can enhance the body's muscle mass, increase muscle oxygen content and endurance, and reduce muscle soreness and fatigue. Studies have shown that spermidine can increase the muscle alanine content in muscles, increase muscle oxygen content, and delay the occurrence of muscle fatigue.
Balance blood sugar and promote insulin synthesis
Spermidine trihydrochloride can promote the synthesis and secretion of insulin, improve blood sugar utilization, help control blood sugar levels, and alleviate the symptoms of diabetes.
Promote physical growth and development
Spermidine can stimulate the body to produce antibodies and increase the body's immunity. Spermidine is one of the necessary components for protein production in the body and can promote the growth and development of the body.
Promote intestinal health
Spermidine trihydrochloride is a nutrient for beneficial bacteria in the intestines. It can promote the reproduction and growth of beneficial bacteria in the intestines, maintain the balance of intestinal flora, and promote intestinal health.
Regulate and protect nerves
Spermidine has antioxidant and anti-inflammatory effects on neurodegeneration, can improve learning and memory, protect nerve cells, and prevent Alzheimer's disease. Spermidine can also prevent age-related memory loss.
In what fields can spermidine trihydrochloride be used?
Food
In the food industry, it is widely used as a common additive in foods such as condiments, bread, meat products and vegetable products.Spermidine trihydrochloride has excellent moisturizing and thickening properties, which enable it to improve the texture of food and extend the shelf life of food. By increasing the texture and shelf life of food, the overall quality of food is improved.
In addition to the above, spermidine trihydrochloride can also achieve the long-term effect of drugs by increasing the solubility of drugs and promoting the absorption of drugs. In the food industry, this ability can be used to improve the taste and nutritional value of food.
Medicine
Spermidine trihydrochloride can repair damaged cells, enhance cell autophagy, and thus delay the aging process of the body. As a potential drug for anti-aging treatment, it has broad research and application prospects.Studies have shown that spermidine trihydrochloride can stimulate the body to produce lymphocytes and antibodies, improve immunity, and prevent the occurrence of various diseases.
Agriculture
Spermidine trihydrochloride is an effective herbicide that can inhibit the growth of weeds and protect the growth of crops. In recent years, with the continuous progress in the research and development of spermidine trihydrochloride, its application value in agricultural production has been increasingly valued.
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