BENTLEY PHARMACEUTICALS, INC.
                                65 LAFAYETTE ROAD
                                   THIRD FLOOR
                             NORTH HAMPTON, NH 03862

                                   -----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                                   May 9, 2001

                                  ------------

                                                               North Hampton, NH
                                                                   April 3, 2001
To the Stockholders of
Bentley Pharmaceuticals, Inc.

         NOTICE IS HEREBY GIVEN that the 2001 Annual Meeting (the  "Meeting") of
Stockholders  of BENTLEY  PHARMACEUTICALS,  INC.,  a Delaware  corporation  (the
"Company"),  will be held on Wednesday, May 9, 2001 at 11:00 a.m., local time at
the Hyatt  Harborside Hotel at Boston's Logan  International  Airport located at
101 Harborside Drive, Boston, Massachusetts 02128 for the purpose of considering
and acting upon the following matters:

     (1)  The  election  of three  Class II  Directors  to serve  until the 2004
          Annual   Meeting  of   Stockholders,   or  until  the   election   and
          qualification of their respective successors;

     (2)  A proposal to approve the Company's 2001 Employee Stock Option Plan;

     (3)  A proposal to approve the Company's 2001 Directors' Stock Option Plan;
          and

     (4)  The  transaction  of such other  business  as may  properly be brought
          before the meeting or any adjournment or postponement thereof.

         The Board of Directors has fixed the close of business on April 3, 2001
as the record date for the determination of stockholders  entitled to notice of,
and to vote at, the Meeting.  A complete  list of the  Stockholders  entitled to
vote will be available for inspection by any Stockholder during the Meeting;  in
addition,  the list will be open for  examination  by any  Stockholder,  for any
purpose germane to the Meeting,  during ordinary business hours, for a period of
at least 10 days  prior to the  Meeting,  at the  Company's  principal  place of
business located at 65 Lafayette Road, Third Floor, North Hampton, New Hampshire
03862.

         You are  cordially  invited to attend the  Meeting.  Whether or not you
intend to attend  the  Meeting,  you are  urged to  complete,  sign and date the
enclosed form of proxy,  and return it promptly in the enclosed reply  envelope.
No postage is required if mailed in the United States. Returning your proxy does
not  deprive  you of your right to attend the Meeting and to vote your shares in
person.  THIS  SOLICITATION  IS BEING MADE ON BEHALF OF THE  COMPANY'S  BOARD OF
DIRECTORS.

                                       By Order of the Board of Directors
                                       MICHAEL D. PRICE
                                       Secretary






                          BENTLEY PHARMACEUTICALS, INC.
                                65 Lafayette Road
                                   Third Floor
                             North Hampton, NH 03862

                            -------------------------

                                 PROXY STATEMENT

                       For Annual Meeting of Stockholders

                                   May 9, 2001

                            ------------------------

         This Proxy Statement, to be mailed to stockholders on or about April 9,
2001, is furnished in connection with the solicitation by the Board of Directors
of Bentley  Pharmaceuticals,  Inc., a Delaware  corporation (the "Company"),  of
proxies in the  accompanying  form  ("Proxy" or  "Proxies")  for use at the 2001
Annual Meeting of Stockholders of the Company to be held on May 9, 2001 at 11:00
a.m., local time at the Hyatt  Harborside Hotel at Boston's Logan  International
Airport located at 101 Harborside Drive, Boston,  Massachusetts 02128 and at any
adjournments or postponements thereof (the "Meeting").

          All  Proxies   received   will  be  voted  in   accordance   with  the
specifications  made  thereon or, in the absence of any  specification,  for the
election of all of the nominees  named herein to serve as Directors  and for the
proposals  to approve the  Company's  2001  Employee  Stock  Option Plan and the
Company's 2001 Directors' Stock Option Plan (together,  the "Plans").  Any Proxy
given pursuant to this  solicitation  may be revoked by the person giving it any
time prior to the exercise of the powers conferred  thereby by notice in writing
to Michael D. Price,  Secretary of the Company,  65 Lafayette Road, Third Floor,
North Hampton,  New Hampshire  03862,  by execution and delivery of a subsequent
Proxy or by  attendance  and voting in person at the  Meeting,  except as to any
matter or matters upon which,  prior to such revocation,  a vote shall have been
cast pursuant to the authority conferred by such Proxy.

          Only holders of record of the Company's issued and outstanding  Common
Stock, $.02 par value (the "Common Stock"), as of the close of business on April
3, 2001 (the  "Record  Date") will be entitled to notice of, and to vote at, the
Meeting.  As of the Record Date,  there were issued and  outstanding  13,918,325
shares of the Company's Common Stock, each of which is entitled to one vote upon
each matter at the Meeting.  The holders of a majority of the shares entitled to
vote at the Meeting will  constitute a quorum for the  transaction  of business.
Proxies  submitted which contain  abstentions or broker non-votes will be deemed
present at the Meeting in determining  the presence of a quorum.  A plurality of
the votes cast at the Meeting at which a quorum is present  will be required for
the election of Directors  and the  affirmative  vote of a majority of the votes
cast at the  Meeting at which a quorum is present  will be  required  to approve
each of the Plans.  Shares of Common  Stock that are voted to abstain and shares
which are subject to broker  non-votes will not be considered  cast with respect
to the  proposal to elect  Directors  and the  proposal  to approve  each of the
Plans.




                 SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS

         The following  table sets forth  information as of March 23, 2001 as to
(i) each person  (including any "group" as that term is used in Section 13(d)(3)
of the Securities  Exchange Act of 1934, as amended) who is known to the Company
to be the  beneficial  owner of more than five percent of the  Company's  Common
Stock, its only class of voting securities, and (ii) the shares of the Company's
Common Stock  beneficially  owned by all executive officers and directors of the
Company as a group.




                                                               Amount and
                                                                Nature of
                                                                Beneficial              Percent
          Name and Address of Beneficial Owner                 Ownership (1)            of Class
          ------------------------------------                 -------------            --------
                                                                                    

          Michael McGovern, J.D., C.P.A.                          2,636,228(2)            17.19%
          5910 Long Island Drive
          Atlanta, GA 30328


          Renaissance U.S. Growth and Income Trust PLC            1,104,400(3)             7.93%
          8080 North Central Expressway
          Suite 210, LB59
          Dallas, TX  75206-1857


          Renaissance Capital Growth and Income Fund III, Inc.      924,979(4)             6.63%
          8080 North Central Expressway
          Suite 210, LB59
          Dallas, TX  75206-1857


          James R. Murphy                                           835,071(5)             5.69%
          4 John Starke Lane
          North Hampton, NH 03842


          All executive officers and                              6,781,516(6)            39.38%
          directors as a group (10 persons)

--------------------------------




(1)      Except  as  otherwise  indicated,   all  shares  of  Common  Stock  are
         beneficially  owned,  and sole  investment and voting power is held, by
         the persons named.

(2)      Includes  1,313,500  shares of Common Stock which Mr.  McGovern has the
         right to acquire  pursuant to presently  exercisable  Class B Warrants,
         65,328  shares of Common  Stock  which  Mr.  McGovern  has the right to
         acquire  pursuant to presently  exercisable  stock purchase options and
         25,000  shares of Common  Stock  which  Mr.  McGovern  has the right to
         acquire  pursuant to stock purchase  options that are scheduled to vest
         and become exercisable within 60 days. Excludes 86,000 shares of Common
         Stock  which Mr.  McGovern  has the right to acquire  pursuant to stock
         purchase  options  which are not vested and not  exercisable  within 60
         days.

               (Footnote explanations continue on following page)

                                       2




(3)      Based upon  information  contained in Amendment  No. 5 to Schedule 13G,
         dated December 26, 2000, and Form 4's filed by Mr. Cleveland, President
         and  Director of  Renaissance  U.S.  Growth and Income  Trust PLC and a
         Director of the Company.

(4)      Based upon  information  contained in Amendment  No. 7 to Schedule 13G,
         dated December 7, 2000, and Form 4's filed by Mr. Cleveland,  President
         and CEO of  Renaissance  Capital Growth and Income Fund III, Inc. and a
         Director of the  Company.  Includes  7,779 shares of Common Stock which
         Renaissance  Capital  Growth and Income Fund III, Inc. has the right to
         acquire  pursuant to  presently  exercisable  stock  purchase  options.
         Excludes 12,012 shares of Common Stock which Renaissance Capital Growth
         and Income Fund III,  Inc.  has the right to acquire  pursuant to stock
         purchase  options  which are not vested and not  exercisable  within 60
         days.

(5)      Includes 1,300 shares of Common Stock owned by Mr. Murphy's sons, as to
         which Mr. Murphy disclaims  beneficial  ownership,  and 2,784 shares of
         Common  Stock  held  in Mr.  Murphy's  401(k)  Retirement  Plan.  Also,
         includes  728,000 shares of Common Stock which Mr. Murphy has the right
         to acquire  pursuant to presently  exercisable  stock options and 1,500
         shares  of  Common  Stock  which Mr.  Murphy  has the right to  acquire
         pursuant to presently  exercisable  Class B Warrants.  Excludes  17,400
         shares  of  Common  Stock  which Mr.  Murphy  has the right to  acquire
         pursuant  to  stock  purchase  options  which  are not  vested  and not
         exercisable within 60 days.

 (6)     Includes  1,401  shares of Common  Stock  owned by  family  members  of
         certain of the current  Executive  Officers and Directors,  as to which
         such Executive  Officers and Directors disclaim  beneficial  ownership.
         Also  includes  1,946,456  shares of Common Stock which  certain of the
         current  Executive  Officers  and  Directors  have a right  to  acquire
         pursuant to presently  exercisable  stock options,  1,321,000 shares of
         Common  Stock  which  certain of the  current  Executive  Officers  and
         Directors  have a right to acquire  pursuant to  presently  exercisable
         Class  B  Warrants,  8,432  shares  of  Common  Stock  held  in  401(k)
         Retirement Plan accounts of certain of the current  Executive  Officers
         and  Directors and 9,970 shares of Common Stock held the IRA account of
         a certain  Executive  Officer and  Director.  Also  includes  1,104,400
         shares of Common Stock held by Renaissance U.S. Growth and Income Trust
         PLC, of which Russell Cleveland,  a director of the Company,  serves as
         President  and  Director  and  917,200  shares of Common  Stock held by
         Renaissance  Capital  Growth and Income  Fund III,  Inc.,  of which Mr.
         Cleveland  serves as  President  and CEO, as to all of which shares Mr.
         Cleveland  disclaims  beneficial  ownership.  Also  includes  7,779 and
         9,121shares of Common Stock which Renaissance Capital Growth and Income
         Fund III, Inc. and Renaissance Capital Group, Inc., respectively,  have
         the right to acquire pursuant to presently  exercisable  stock purchase
         options.  Excludes  335,300,  12,012 and 15,288  shares of Common Stock
         which  certain  of  the  current  Executive   Officers  and  Directors,
         Renaissance  Capital  Growth and Income Fund III, Inc. and  Renaissance
         Capital Group, Inc.,  respectively,  have the right to acquire pursuant
         to stock  purchase  options  which are not vested  and not  exercisable
         within 60 days.  Mr.  Cleveland  is a Director  of the  Company  and an
         executive  officer of  Renaissance  Capital Group,  Inc.,  which is the
         Investment  Advisor to Renaissance  Capital Growth and Income Fund III,
         Inc. and the Investment  Manager to Renaissance U. S. Growth and Income
         Trust PLC.





                                       3




                        SECURITY OWNERSHIP OF MANAGEMENT

         The  following  table  sets  forth  information   regarding  beneficial
ownership  of the  Company's  Common  Stock as of March 23,  2001 as to (i) each
Director and nominee for Director of the Company, (ii) each Executive Officer of
the Company named in the Summary  Compensation  Table set forth below, and (iii)
all current executive officers and directors as a group.





                                                              Amount and Nature of      Percent
Name                                                         Beneficial Ownership (1)   of Class
----                                                         ------------------------   --------
                                                                                     

James R. Murphy                                                  835,071(2)                5.69%
Chairman of the Board, President,
Chief Executive Officer and Director

Robert M. Stote, M.D.                                            617,903(3)                4.26%
Senior Vice President, Chief
Science Officer and Director

Michael D. Price                                                 469,519(4)                3.26%
Vice President, Chief
Financial Officer, Secretary,
Treasurer and Director

Robert J. Gyurik                                                   92,699(5)               *
Vice President of Pharmaceutical
Development and Director

Jordan A. Horvath                                                   3,300(6)               *
Vice President and General Counsel

Charles L. Bolling                                                 48,328(7)               *
Director

Russell Cleveland                                               2,038,500(8)              14.61%
Director

Miguel Fernandez                                                   22,368(9)               *
Director

Michael McGovern, J.D., C.P.A.                                 2,636,228(10)              17.19%
Director

William A. Packer                                                 17,600(11)               *
Director

All executive officers
and directors as a group (10 persons)                          6,781,516(12)              39.38%
---------------------------------
     *   Less than one percent


               (Footnote explanations continue on following page)

                                       4




(1)      Except as otherwise  indicated,  all shares are beneficially owned, and
         sole investment and voting power is held by the persons named.

(2)      Includes 1,300 shares of Common Stock owned by Mr. Murphy's sons, as to
         which Mr. Murphy disclaims  beneficial  ownership,  and 2,784 shares of
         Common  Stock  held  in Mr.  Murphy's  401(k)  Retirement  Plan.  Also,
         includes  728,000 shares of Common Stock which Mr. Murphy has the right
         to acquire  pursuant to presently  exercisable  stock options and 1,500
         shares  of  Common  Stock  which Mr.  Murphy  has the right to  acquire
         pursuant to presently  exercisable  Class B Warrants.  Excludes  17,400
         shares  of  Common  Stock  which Mr.  Murphy  has the right to  acquire
         pursuant  to  stock  purchase  options  which  are not  vested  and not
         exercisable within 60 days.

(3)      Includes  1,703  shares  of Common  Stock  held in Dr.  Stote's  401(k)
         Retirement Plan, 567,500 shares of Common Stock which Dr. Stote has the
         right to acquire  pursuant to presently  exercisable  stock options and
         5,000  shares of Common  Stock which Dr. Stote has the right to acquire
         pursuant to presently exercisable Class B Warrants.

(4)      Includes  101 shares of Common  Stock owned by Mr.  Price's  son, as to
         which Mr. Price  disclaims  beneficial  ownership,  and 2,216 shares of
         Common Stock held in Mr. Price's 401(k)  Retirement Plan. Also includes
         446,500 shares of Common Stock which Mr. Price has the right to acquire
         pursuant to presently exercisable stock options.

(5)      Includes  9,970 shares of Common Stock and 1,000 shares of Common Stock
         issuable  upon exercise of Class B Warrants  owned by Mr.  Gyurik's IRA
         and 1,729 shares of Common Stock held in Mr. Gyurik's 401(k) Retirement
         Plan.  Also includes 40,000 shares of Common Stock which Mr. Gyurik has
         the right to acquire pursuant to presently exercisable stock options.

(6)      Excludes 150,000 shares of Common Stock which Mr. Horvath has the right
         to acquire  pursuant to stock purchase options which are not vested and
         not exercisable within 60 days.

(7)      Includes  40,328 shares of Common Stock which Mr. Bolling has the right
         to acquire pursuant to presently  exercisable  stock options.  Excludes
         27,300  shares  of Common  Stock  which  Mr.  Bolling  has the right to
         acquire pursuant to stock purchase options which are not vested and not
         exercisable within 60 days.

(8)      Includes  1,104,400  shares of Common  Stock held by  Renaissance  U.S.
         Growth and Income Trust PLC, of which Mr. Cleveland serves as President
         and Director,  and 917,200  shares of Common Stock held by  Renaissance
         Capital Growth and Income Fund III, Inc., of which Mr. Cleveland serves
         as President and CEO, as to all of which shares Mr. Cleveland disclaims
         beneficial  ownership.  Also includes  7,779 and  9,121shares of Common
         Stock which  Renaissance  Capital  Growth and Income Fund III, Inc. and
         Renaissance  Capital  Group,  Inc.,  respectively,  have  the  right to
         acquire  pursuant to  presently  exercisable  stock  purchase  options.
         Excludes  12,012 and 15,288  shares of Common  Stock which  Renaissance
         Capital Growth and Income Fund III, Inc. and Renaissance Capital Group,
         Inc.,  respectively,  have  the  right  to  acquire  pursuant  to stock
         purchase  options  which are not vested and not  exercisable  within 60
         days.  Mr.  Cleveland  is a Director of the  Company  and an  executive
         officer of  Renaissance  Capital Group,  Inc.,  which is the Investment
         Advisor to Renaissance Capital Growth and Income Fund III, Inc. and the
         Investment Manager to Renaissance U. S. Growth and Income Trust PLC.

(9)      Includes  16,900  shares of Common  Stock which Mr.  Fernandez  has the
         right to acquire  pursuant  to  presently  exercisable  stock  purchase
         options. Excludes 27,300 shares of Common Stock which Mr. Fernandez has
         the right to acquire  pursuant to stock purchase  options which are not
         vested and not exercisable within 60 days.

(10)      Includes  1,313,500  shares of Common Stock which Mr. McGovern has the
          right to acquire pursuant to presently  exercisable  Class B Warrants,
          65,328  shares of Common  Stock  which Mr.  McGovern  has the right to
          acquire pursuant to presently  exercisable  stock purchase options and
          25,000  shares of Common  Stock  which Mr.  McGovern  has the right to
          acquire  pursuant to stock purchase options that are scheduled


                                       5


         to vest and become exercisable  within 60 days.  Excludes 86,000 shares
         of Common Stock which Mr. McGovern has the right to acquire pursuant to
         stock purchase options which are not vested and not exercisable  within
         60 days.

(11)     Includes  16,900  shares of Common Stock which Mr. Packer has the right
         to acquire pursuant to presently  exercisable  stock purchase  options.
         Excludes  27,300  shares of Common Stock which Mr. Packer has the right
         to acquire  pursuant to stock purchase options which are not vested and
         not exercisable within 60 days.

(12)     Includes  1,401  shares of Common  Stock  owned by  family  members  of
         certain of the current  Executive  Officers and Directors,  as to which
         such Executive  Officers and Directors disclaim  beneficial  ownership.
         Also  includes  1,946,456  shares of Common Stock which  certain of the
         current  Executive  Officers  and  Directors  have a right  to  acquire
         pursuant to presently  exercisable  stock options,  1,321,000 shares of
         Common  Stock  which  certain of the  current  Executive  Officers  and
         Directors  have a right to acquire  pursuant to  presently  exercisable
         Class  B  Warrants,  8,432  shares  of  Common  Stock  held  in  401(k)
         Retirement Plan accounts of certain of the current  Executive  Officers
         and  Directors and 9,970 shares of Common Stock held the IRA account of
         a certain  Executive  Officer and  Director.  Also  includes  1,104,400
         shares of Common Stock held by Renaissance U.S. Growth and Income Trust
         PLC, of which Russell Cleveland,  a director of the Company,  serves as
         President  and  Director  and  917,200  shares of Common  Stock held by
         Renaissance  Capital  Growth and Income  Fund III,  Inc.,  of which Mr.
         Cleveland  serves as  President  and CEO, as to all of which shares Mr.
         Cleveland  disclaims  beneficial  ownership.  Also  includes  7,779 and
         9,121shares of Common Stock which Renaissance Capital Growth and Income
         Fund III, Inc. and Renaissance Capital Group, Inc., respectively,  have
         the right to acquire pursuant to presently  exercisable  stock purchase
         options.  Excludes  335,300,  12,012 and 15,288  shares of Common Stock
         which  certain  of  the  current  Executive   Officers  and  Directors,
         Renaissance  Capital  Growth and Income Fund III, Inc. and  Renaissance
         Capital Group, Inc.,  respectively,  have the right to acquire pursuant
         to stock  purchase  options  which are not vested  and not  exercisable
         within 60 days.  Mr.  Cleveland  is a Director  of the  Company  and an
         executive  officer of  Renaissance  Capital Group,  Inc.,  which is the
         Investment  Advisor to Renaissance  Capital Growth and Income Fund III,
         Inc. and the Investment  Manager to Renaissance U. S. Growth and Income
         Trust PLC.


                                       6




                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

          The  Company's  Articles of  Incorporation  and By-Laws  provide for a
classified  Board  of  Directors.  The  Board  is  divided  into  three  classes
designated  Class I, Class II and Class III. The  nominees  included in Class II
below are being  presented  for  election as Class II  Directors  to hold office
until  the  2004  Annual  Meeting  of  Stockholders.  Unless  instructed  to the
contrary,  the  persons  named in the  enclosed  Proxy  intend to cast all votes
pursuant  to Proxies  received in favor of the person  listed  under the heading
"Nominees" below as Directors.  The nominees have indicated to the Company their
availability  for  election;  Messrs.  Bolling,  Gyurik and Packer are presently
directors.  In the event that the  nominees  should not continue to be available
for election,  the holders of the Proxies may exercise their  discretion to vote
for a  substitute.  Officers  hold  office  until  the  meeting  of the Board of
Directors  following  each  Annual  Meeting  of  Stockholders  and  until  their
successors have been chosen and qualified.

          The following  information  is furnished  with respect to the nominees
and each other continuing member of the Company's Board of Directors.



                                                                                        Class of       Year
                                             Positions with                             Director       First
                                             the Company                                (Upon          Became
Name                            Age          Presently Held                             Election)     Director
----                            ---          --------------                             ---------     --------
                                                                                            

Nominees:

Charles L. Bolling              77           Director                                    II             1991

Robert J. Gyurik                54           Vice President of Pharmaceutical            II             1998
                                             Development and Director

William A. Packer               66           Director                                    II             1999

Directors Whose Terms of Office
Continue After the Meeting:

Russell Cleveland               62           Director                                    I              1999

Miguel Fernandez                70           Director                                    III            1999

Michael McGovern                57           Director                                    I              1997

James R. Murphy                 51           Chairman of the Board, President,           III            1993
                                             Chief Executive Officer and Director

Michael D. Price                43           Vice President, Chief Financial             I              1995
                                             Officer, Secretary, Treasurer
                                             and Director

Robert M. Stote, M.D.           61           Senior Vice President, Chief                III            1993
                                             Science Officer and Director




                                       7



BACKGROUND OF NOMINEES

         CHARLES  L.  BOLLING  served  from  1968 to 1973 as Vice  President  of
Product Management and Promotion (U.S.),  from 1973 to 1977 as Vice President of
Commercial Development and from 1977 to 1986 as Director of Business Development
(International)  at Smith  Kline & French  Laboratories.  Mr.  Bolling  has been
retired since 1986.

         ROBERT J. GYURIK became Vice President of Pharmaceutical Development of
the Company in March 1999 and became a member of the Board of Directors in 1998.
Prior to joining the Company,  Mr. Gyurik served as Manager of  Development  and
Quality  Control  at  MacroChem  Corporation,  a  position  he held from 1993 to
February  1999.  From 1971 to 1993,  Mr. Gyurik  worked in various  positions at
SmithKline   Beecham   ranging  from  Associate   Senior   Investigator  in  the
Nutrition/Production  Enhancer  Research  Group and  Pharmaceutical  Development
Group to Senior  Medical  Chemist  in the  Parasitology  Research  Group.  Prior
thereto,  Mr.  Gyurik  worked at  Schering as a Medicinal  Chemist.  Mr.  Gyurik
attended  Rutgers  University  and received a B.A. in Biology and Chemistry from
Immaculata  College.  Mr. Gyurik is a member of the American  Chemical  Society,
International Society for Chronobiology and the New York Academy of Sciences and
holds a number of patents in the areas of drug delivery systems, medical devices
and new drug discoveries.

         WILLIAM A.  PACKER has been a business  and  industry  consultant  to a
number of  biopharmaceutical  companies  since 1998.  From 1992 until 1998,  Mr.
Packer was President and Chief  Financial  Officer of Virus Research  Institute,
Inc., a  publicly-owned  biotechnology  company.  Prior to this,  Mr. Packer was
employed  by  SmithKline  Beecham  Plc  ("SmithKline"),  a major  pharmaceutical
company,  where he held various senior management positions,  the most recent as
Senior Vice President, Biologicals, in which position he was responsible for the
direction of  SmithKline's  global vaccine  business.  Mr. Packer is a Chartered
Accountant.

BACKGROUND OF CONTINUING DIRECTORS

         RUSSELL CLEVELAND is the principal founder and the majority stockholder
of Renaissance Capital Group, Inc. ("Renaissance"). Renaissance provides capital
to emerging  publicly-owned  companies.  For more than the past five years,  Mr.
Cleveland has served as President and Managing  General  Partner of  Renaissance
Capital Partners,  Ltd.,  President and Director of Renaissance Capital Growth &
Income Fund III,  Inc.,  and a Director of  Renaissance  U.S.  Growth and Income
Trust  PLC and  BFS  U.S.  Special  Opportunities  Trust  PLC.  Mr.  Cleveland's
background  includes  executive  positions with various major southwest regional
brokerage  firms.  Mr.  Cleveland also currently  serves as a director of Danzer
Corp.  (formerly  Global  Environmental   Corp.),   Tutogen  Medical,  Inc.  and
Integrated Security Systems, Inc. Mr. Cleveland is a Chartered Financial Analyst
and a graduate of the University of Pennsylvania,  Wharton School of Finance and
Commerce.

         MIGUEL  FERNANDEZ  served  from  1980  to  1996  as  President  of  the
International  Division and Corporate  Vice President at  Carter-Wallace,  Inc.,
where he was  responsible  for all product lines  outside of the United  States.
Prior  thereto,  Mr.  Fernandez  was employed for  approximately  eight years by
SmithKline Beecham, where his last position was Vice President for Europe, where
he was  based.  He also  served  in the  capacity  of Vice  President  for Latin
America. Before SmithKline Beecham, Mr. Fernandez served as Managing Director of
Warner Lambert in Argentina for two years.  From 1962 to 1970, Mr. Fernandez was
employed  by  Merck/Frost  in Canada.  Mr.  Fernandez  received a  Bachelors  of
Commerce degree from the University of British Columbia and an MBA from the Ivey
School of  Business  at the  University  of  Western  in  Ontario,  Canada.  Mr.
Fernandez has been retired since 1996.

                                       8



         MICHAEL  MCGOVERN,  J.D., C.P.A. was named Vice Chairman of the Company
in October 1999 and serves as President of McGovern  Enterprises,  a provider of
corporate  and  financial  consulting  services,  which he founded in 1975.  Mr.
McGovern is Chairman of the Board of Directors of Specialty Surgicenters,  Inc.,
is the Vice Chairman of the Board of Directors of Employment Technologies,  Inc.
and is a Director on the  corporate  boards of Suburban  Lodges of America Inc.,
Training Solutions Interactive,  Inc., and the Reynolds Development Company. Mr.
McGovern  received a B.S. and M.S. in  accounting  and his Juris Doctor from the
University of Illinois.  Mr.  McGovern is a Certified  Public  Accountant  and a
member of the state bar of Georgia and the American Bar Association.

         JAMES R. MURPHY  became  President and Chief  Operating  Officer of the
Company on  September  7, 1994,  was named  Chief  Executive  Officer  effective
January  1, 1995 and  became  Chairman  of the Board on June 9,  1995.  Prior to
rejoining  the  Company,  Mr.  Murphy  served  as  Vice  President  of  Business
Development at MacroChem Corporation,  a publicly-owned  pharmaceutical company,
from March 1993 through  September  1994.  From September 1992 until March 1993,
Mr.  Murphy  served as a  consultant  to the  pharmaceutical  industry  with his
primary efforts  directed toward product  licensing.  Prior thereto,  Mr. Murphy
served as Director - Worldwide  Business  Development and Strategic  Planning of
the Company from December 1991 to September 1992. Mr. Murphy previously spent 14
years in basic  pharmaceutical  research and product development with SmithKline
Beecham  Corporation and in  international  business  development  with contract
research and consulting laboratories. Mr. Murphy received a B.A. in Biology from
Millersville University and attended the Massachusetts School of Law in 1993 and
1994.

         MICHAEL   D.   PRICE   became    Chief    Financial    Officer,    Vice
President/Treasurer and Secretary of the Company in October 1993, April 1993 and
November 1992, respectively. He has served the Company in other capacities since
March 1992. Prior to joining the Company,  Mr. Price was employed as a financial
and management consultant with Carr Financial Group in Tampa, Florida from March
1990 to March 1992. Prior thereto,  he was employed as Vice President of Finance
with Premiere  Group,  Inc., in Tampa,  Florida from June 1988 to February 1990.
Prior thereto, Mr. Price was employed by Price Waterhouse in Tampa, Florida from
January 1982 to June 1988 where his last position with that firm was as an Audit
Manager.   Mr.  Price  received  a  B.S.  in  Business   Administration  with  a
concentration  in Accounting from Auburn  University and an M.B.A.  from Florida
State  University.  Mr. Price is a Certified  Public  Accountant in the State of
Florida.

         ROBERT M. STOTE,  M.D.  became Senior Vice  President and Chief Science
Officer of the Company in March 1992.  Prior to joining the  Company,  Dr. Stote
was employed for 20 years by SmithKline  Beecham  Corporation  serving as Senior
Vice  President and Medical  Director,  Worldwide  Medical  Affairs from 1989 to
1992, and Vice President-Clinical Pharmacology-Worldwide from 1987 to 1989. From
1984 to 1987 Dr.  Stote was Vice  President-Phase  I  Clinical  Research,  North
America.  Dr. Stote was Chief of Nephrology at  Presbyterian  Medical  Center of
Philadelphia  from 1972 to 1989 and was  Clinical  Professor  of Medicine at the
University  of  Pennsylvania.  Dr. Stote serves as a director of DataTrak,  Inc.
(formerly  Collaborative Clinical Research,  Inc.). Dr. Stote received a B.S. in
Pharmacy  from the Albany  College of  Pharmacy,  an M.D.  from  Albany  Medical
College and is Board  Certified in Internal  Medicine and  Nephrology.  He was a
Fellow in Nephrology and Internal Medicine at the Mayo Clinic and is currently a
Fellow of the American College of Physicians.

                                       9



COMMITTEES OF THE BOARD OF DIRECTORS; BOARD OF DIRECTORS MEETINGS

         The Board of Directors has an Audit Committee, a Compensation Committee
and a Strategic Planning Committee.  The Audit Committee recommends to the Board
of Directors  the  appointment  of  independent  auditors to audit the Company's
consolidated  financial  statements,  reviews  the  Company's  internal  control
procedures  and advises the Company on tax and other matters  connected with the
finances and reporting  obligations  of the Company.  The Audit  Committee  also
reviews  with  management  the  annual  audit and other  work  performed  by the
independent auditors.  The Compensation Committee administers the Company's 1991
and 2001 Stock Option Plans and reviews and recommends to the Board of Directors
the nature  and amount of  compensation  to be paid to the  Company's  executive
officers and employees that earn in excess of $100,000  annually.  The Strategic
Planning  Committee  advises  the  Board  and  Management  with  respect  to the
strategic  direction of the Company.  The Audit Committee  currently consists of
Messrs.  Charles Bolling,  Miguel Fernandez and William Packer; the Compensation
Committee  currently  consists of Messrs.  Charles Bolling,  Russell  Cleveland,
Miguel  Fernandez,  Michael  McGovern  and  William  Packer;  and the  Strategic
Planning  Committee  currently  consists of Messrs.  Russell  Cleveland,  Miguel
Fernandez, Michael McGovern, James Murphy and William Packer.

         During the  Company's  last fiscal year ended  December 31,  2000,  the
Board of Directors held six meetings,  the Audit Committee held two meetings and
the Compensation  Committee held four meetings. The Strategic Planning Committee
held no formal  meetings during the year ended December 31, 2000,  however,  the
members  held  informal  discussions  at various  times  during  the year.  Each
Director  attended at least 75% of the total  number of meetings of the Board of
Directors  which were held  during  the  period he served as a  Director  in the
fiscal year ended December 31, 2000 and meetings of each Committee on which such
Director served.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         The members of the Compensation  Committee during the fiscal year ended
December 31, 2000 were Messrs.  Charles L. Bolling,  Miguel  Fernandez,  Michael
McGovern and William Packer, all of whom are now and were at the time of service
non-employee   Directors.   No  member  of  the  Compensation  Committee  has  a
relationship  that would constitute an interlocking  relationship with Executive
Officers or Directors of the Company or another entity.

REMUNERATION OF NON-EMPLOYEE DIRECTORS

         The Company  presently  pays  non-employee  Director fees of $3,000 for
each  in-person  meeting  of the Board of  Directors,  $500 for each  telephonic
meeting,  $500  for  each  committee  meeting  of the  Board  of  Directors  and
reimburses expenses incurred in attending meetings.  Total non-employee Director
fee  payments  during the year ended  December 31, 2000  totaled  $66,500.  Each
non-employee  director is automatically  granted options to purchase a number of
shares of Common Stock equal to 2/10 of 1% of the number of  outstanding  shares
of  Common  Stock  upon  his or her  election  to the  Board.  Thereafter,  each
continuing  non-employee director is entitled to receive,  annually,  options to
purchase  the number of shares of Common Stock equal to 2/10 of 1% of the number
of outstanding  shares of Common Stock.  In addition,  the Company has agreed to
compensate the Vice Chairman for his time and efforts,  which are in addition to
other  directors,  by awarding him options to purchase  100,000 shares of Common
Stock  (25,000 on each of January 1, April 1, July 1, and October 1, 2000),  for
service  during the years  ending  December  31, 2000 and 2001.  During the year
ended December 31, 2000, options to purchase 236,500 shares of Common Stock were
granted at prices ranging from $5.87 to $10.75 per share,  representing at least
the fair  market  value of the  Common  Stock on the date of the  grants.  These
options expire on dates ranging from January 3, 2010 to October 1, 2010.

                                       10



                             EXECUTIVE COMPENSATION

Summary Compensation Table

         The  following  table  sets  forth  the total  compensation  paid to or
accrued by the Company for the account of the current  Chief  Executive  Officer
and the  executive  officers at December 31, 2000 whose total cash  compensation
for the year ended December 31, 2000 exceeded $100,000.

                           SUMMARY COMPENSATION TABLE



                                                                                 Long-Term Compensation
                                                                             --------------------------------
                                        Annual Compensation                          Awards          Payouts
                                        -------------------                  ----------------------  --------
                                                                                         Securities
                                                                  Other      Restricted  Underlying    LTIP        All
                                                                  Annual       Stock      Options/    Payouts     Other
Name and Principal Position     Year      Salary($)   Bonus($)  Comp.($)(1)   Awards($)    SARs(#)     ($)        Comp.
---------------------------     ----      ---------  ---------  -----------  ---------    --------    -------     -----
                                                                                        
James R. Murphy (2)         Y/E 12/31/00   $366,923  $170,000     $12,000       ---        ---        ---       $10,500
Chairman of the Board,      Y/E 12/31/99   $295,577     ---         ---      $120,000      ---        ---       $ 5,000
President, Chief Executive  Y/E 12/31/98   $260,000  $ 37,381       ---         ---        ---        ---       $ 5,000
Officer and Director

Robert M. Stote (3)         Y/E 12/31/00   $ 94,589  $ 15,000      ---         ---         ---        ---       $10,500
Senior Vice President,      Y/E 12/31/99   $110,449     ---        ---       $ 22,500      ---        ---       $ 5,000
Chief Science Officer and   Y/E 12/31/98   $200,178  $ 33,694      ---         ---         ---        ---       $ 5,000
Director

Michael D. Price (4)        Y/E 12/31/00   $188,685  $ 30,000      ---         ---         ---        ---       $10,500
Vice President, Chief       Y/E 12/31/99   $176,231     ---        ---       $ 22,500      ---        ---       $ 5,000
Financial Officer,          Y/E 12/31/98   $155,958  $ 11,985      ---         ---         ---        ---       $ 5,000
Treasurer, Secretary and
Director

Robert J. Gyurik (5)        Y/E 12/31/00    $138,903 $ 30,000       ---         ---        ---        ---       $10,500
Vice President of           Y/E 12/31/99     $99,808    ---         ---      $ 67,500      ---        ---        ---
Pharmaceutical
Development and Director

Jordan A. Horvath (6)       Y/E 12/31/00    $112,109    ---       $11,625       ---        ---        ---        ---
Vice President and
General Counsel



-------------------------------

(1)      The value of perquisites  provided to the named executive  officers did
         not exceed 10% of total compensation in any case.

(2)      Mr.  Murphy,  Chairman  of the  Board,  President  and Chief  Executive
         Officer,  has been employed by the Company since  September  1994.  Mr.
         Murphy's  annual  salary is currently  $385,200.  During the year ended
         December 31, 1999, Mr. Murphy was awarded 80,000 shares of Common Stock
         of the Company as a bonus,  which shares were treated as taxable income
         in the year 2000.  The Company  provided a loan to Mr.  Murphy in March
         2000,  in the  amount of  $250,000,  which Mr.  Murphy  used to pay the
         income taxes on such equity-based  compensation.  The loan, which bears
         interest at 6.59% annually, matures on March 17, 2003 and is secured by
         28,000  shares of the Company's  Common  Stock,  which are owned by Mr.
         Murphy. Interest accrues quarterly. During the years ended December 31,
         2000, 1999 and 1998, the Company  provided to Mr. Murphy matching funds
         totaling $970, $5,000 and $5,000,  respectively,  pursuant to the terms
         of a Company  sponsored 401(k)  retirement plan.  During the year ended
         December  31,  2000,   the  Company  also  provided   matching   401(k)
         contributions  in the form of 1,149  shares of Common  Stock  valued at
         $9,530 (see "401(k) Retirement Plan").

               (Footnote explanations continue on following page)

                                       11



(3)      Dr. Stote,  Senior Vice President and Chief Science  Officer,  has been
         employed by the Company  since March 1992.  As of August 31, 1998,  Dr.
         Stote  began  working  part time and  receives an annual base salary of
         $75,000  plus  compensation  at the rate of $130 per hour for all hours
         worked on behalf of the  Company in excess of twelve  per week.  During
         the year ended  December 31, 1999,  Dr. Stote was awarded 15,000 shares
         of Common  Stock of the  Company  as a bonus.  During  the years  ended
         December 31,  2000,  1999 and 1998,  the Company  provided to Dr. Stote
         matching funds totaling $283, $5,000 and $5,000, respectively, pursuant
         to the terms of a Company  sponsored 401(k) retirement plan. During the
         year ended December 31, 2000, the Company also provided matching 401(k)
         contributions  in the form of 1,230  shares of Common  Stock  valued at
         $10,217 (see "401(k) Retirement Plan").

(4)      Mr. Price,  Vice  President,  Chief  Financial  Officer,  Secretary and
         Treasurer,  has been  employed  by the Company  since  March 1992.  Mr.
         Price's  annual  salary is  currently  $194,381.  During the year ended
         December 31, 1999,  Mr. Price was awarded 15,000 shares of Common Stock
         of the Company as a bonus,  which shares were treated as taxable income
         in the year 2000.  The  Company  provided a loan to Mr.  Price in March
         2000, in the amount of $50,000,  which Mr. Price used to pay the income
         taxes on such equity-based compensation. The loan, which bears interest
         at 6.59%  annually,  matures on March 17,  2003 and is secured by 6,000
         shares of the  Company's  Common  Stock,  which are owned by Mr. Price.
         Interest accrues  quarterly.  During the years ended December 31, 2000,
         1999 and  1998,  the  Company  provided  to Mr.  Price  matching  funds
         totaling $551, $5,000 and $5,000,  respectively,  pursuant to the terms
         of a Company  sponsored 401(k)  retirement plan.  During the year ended
         December  31,  2000,   the  Company  also  provided   matching   401(k)
         contributions  in the form of 1,247  shares of Common  Stock  valued at
         $9,949 (see "401(k) Retirement Plan").

(5)      Mr. Gyurik,  Vice  President of  Pharmaceutical  Development,  has been
         employed by the Company since March 1999. Mr. Gyurik's annual salary is
         currently $145,530. During the year ended December 31, 1999, Mr. Gyurik
         was awarded  40,000  shares of Common Stock of the Company as a sign-on
         bonus,  which shares were  treated as taxable  income in the year 2000.
         The Company  provided a loan to Mr. Gyurik in March 2000, in the amount
         of  $140,000,  which Mr.  Gyurik  used to pay the income  taxes on such
         equity-based  compensation.  The loan,  which  bears  interest at 6.59%
         annually,  matures on March 31, 2003 and is secured by 16,000 shares of
         the Company's  Common Stock,  which are owned by Mr.  Gyurik.  Interest
         accrues quarterly. During the year ended December 31, 2000, the Company
         provided to Mr. Gyurik  matching funds  totaling $263,  pursuant to the
         terms of a Company  sponsored 401(k)  retirement plan.  During the year
         ended  December 31, 2000,  the Company also  provided  matching  401(k)
         contributions  in the form of 1,245  shares of Common  Stock  valued at
         $10,237 (see "401(k) Retirement Plan").

(6)      Mr. Horvath,  Vice President and General Counsel,  has been employed by
         the Company since August 2000. Mr. Horvath's annual salary is currently
         $304,500.  During the year ended  December  31, 2000,  Mr.  Horvath was
         awarded 1,500 shares of Common Stock of the Company as  compensation in
         lieu of cash,  which shares were treated as taxable  income in the year
         2000.

                                       12





Option/SAR Grants in Last Fiscal Year

         The  following  table sets forth the details of options  granted to the
individuals  listed in the  Summary  Compensation  table  during  the year ended
December 31, 2000. No stock appreciation rights have been granted to date.




                                                                                               Potential
                                                                                              Realizable
                                                     Individual Grants                         Value at
                                                                                               Assumed
                                                                                             Annual Rates
                          ----------------------------------------------------------          of Stock
                            Number of      % of Total                                           Price
                           Securities     Options/SARs       Exercise                        Appreciation
                           Underlying      Granted to        or Base                        for Option Terms
                             Options      Employees in        Price      Expiration      -----------------------
           Name            Granted (#)    Fiscal Year       ($/share)       Date         5% ($)         10% ($)
           ----            -----------    -----------       ---------       ----         ------         -------

                                                                                   

James R. Murphy (1)          75,000          13.2%          $ 5.88        1/3/10       $277,110      $   702,240

Robert M. Stote, M.D. (2)    10,000           1.8%          $ 5.88        1/3/10       $ 36,948      $    93,632

Michael D. Price (3)         15,000           2.6%          $ 5.88        1/3/10       $ 55,422      $   140,448

Robert J. Gyurik (4)         25,000           4.4%          $11.81        3/9/10       $185,720      $   470,653

Jordan A. Horvath (5)       150,000          26.3%          $ 7.75       8/14/10       $731,090      $ 1,852,725



---------------------------

(1)      During  the year ended  December  31,  2000,  Mr.  Murphy  was  awarded
         ten-year stock options to purchase 75,000 shares of Common Stock, which
         vest on the first anniversary of the grant date.

(2)      During the year ended December 31, 2000, Dr. Stote was awarded ten-year
         stock options to purchase 10,000 shares of Common Stock,  which vest on
         the first anniversary of the grant date.

(3)      During the year ended December 31, 2000, Mr. Price was awarded ten-year
         stock options to purchase 15,000 shares of Common Stock,  which vest on
         the first anniversary of the grant date.

(4)      During  the year ended  December  31,  2000,  Mr.  Gyurik  was  awarded
         ten-year stock options to purchase 25,000 shares of Common Stock, which
         vest on the first anniversary of the grant date.

(5)      During the year ended  December  31,  2000,  Mr.  Horvath  was  awarded
         ten-year  stock  options to purchase  150,000  shares of Common  Stock,
         50,000  of which  vest and  become  exercisable  on each of the  first,
         second and third anniversaries of the grant date, respectively.

                                       13



Aggregated  Option  Exercises  in Last  Fiscal Year and Fiscal  Year-End  Option
Values

         The  following  table sets forth  certain  information  concerning  the
number of shares of Common Stock  acquired  upon the  exercise of stock  options
during the year ended December 31, 2000 by, and the number and value at December
31, 2000 of shares of Common Stock subject to  unexercised  options held by, the
individuals listed in the Summary Compensation Table.




                                                                           Number of
                                                                           Securities               Value of
                                                                           Underlying              Unexercised
                                                                          Unexercised             In-the-money
                                                                        Options/SARs at          Options/SARs at
                                                                       FY-End (# Shares)             FY-End ($)
                                    Shares                            ------------------        -----------------
                                   Acquired             Value             Exercisable/            Exercisable/
Name                            On Exercise (#)     Realized ($)          Unexercisable         Unexercisable (1)
----                            ---------------     ------------      ------------------        -----------------
                                                                                     

James R. Murphy                        -                  -           728,000  /   17,400        $1,371,250/ -0-

Robert M. Stote, M.D.                  -                  -           567,500  /   -0-           $1,133,854/ -0-

Michael D. Price                       -                  -           446,500  /   -0-           $  891,145/ -0-

Robert J. Gyurik                     1,000             $4,313          40,000  /   -0-           $   58,125/ -0-

Jordan A. Horvath                      -                  -               -0-  /  150,000        $    -0- /  -0-





(1)      Represents  the  closing  price of the  Company's  Common  Stock on the
         American  Stock  Exchange  on December  29,  2000 minus the  respective
         exercise prices.

LONG-TERM INCENTIVE PLAN AWARDS IN LAST FISCAL YEAR

         No  long-term  incentive  plan awards were  granted to the  individuals
listed in the Summary  Compensation  table  during the year ended  December  31,
2000.

EMPLOYMENT AGREEMENTS

         Mr.  James R.  Murphy,  Chairman  of the  Board,  President  and  Chief
Executive Officer,  entered into an employment  agreement with the Company dated
as of July 1, 1998  providing  for an initial term which expires on December 31,
2001. Under the terms of this agreement, as amended, Mr. Murphy's current annual
base salary is $385,200. The Company also provides Mr. Murphy with an automobile
expense  allowance  of $1,000 per month.  The  agreement  with Mr.  Murphy  also
provides for bonuses at the  recommendation  and discretion of the  Compensation
Committee of the Company's Board of Directors. Mr. Murphy is entitled to a bonus
award of 50% of his annual base salary upon (i) the attainment by the Company of
two  consecutive  quarters of net profit,  (ii) the closing of a year with a net
profit,  (iii) the  announcement of a merger of the Company into another company
or a sale or transfer of all or substantially all of the  pharmaceutical  assets
of the Company or (iv) a change in control of the Company.  The  agreement  with
Mr. Murphy also provides that, upon termination following a change in control of
the Company,  Mr.  Murphy  shall be entitled to receive (i) a severance  payment
equal to 2.99 times his annual salary plus bonuses, or that amount of salary and
bonuses that would have been due to Mr.  Murphy  through the  expiration  of the
term of the  agreement,  whichever  is greater,  (ii) a number of stock  options
equal to the number of stock  options held by Mr.  Murphy prior to the effective
date of such change in control  (the  "Termination  Options"),  (iii)  immediate
vesting of all outstanding stock options (including

                                       14


equal to the number of stock  options held by Mr.  Murphy prior to the effective
date of such  change in the  Termination  Options),  and (iv)  health  and other
benefits  through the end of the term of the  agreement  or for a period of five
years,  whichever is greater.  Pursuant to the agreement,  if terminated without
cause, Mr. Murphy will be entitled to a severance  payment equal to two years of
salary  plus bonus and  immediate  vesting  of all  outstanding  non-plan  stock
options.

         Dr. Robert M. Stote,  Senior Vice President and Chief Science  Officer,
entered into an  employment  agreement  with the Company  dated as of August 31,
1998  providing for an initial term which expires on August 31, 2001.  Under the
terms of this  agreement,  Dr.  Stote's  annual  base  salary  is  $75,000  plus
compensation  at the rate of $130 per hour for hours  worked in excess of twelve
per week.  The  agreement  with Dr.  Stote  also  provides  for  bonuses  at the
recommendation  and  discretion of the  Compensation  Committee of the Company's
Board of Directors. Dr. Stote is eligible for a bonus upon (i) the attainment by
the  Company  of two  consecutive  quarters  of  pre-tax  net profit or (ii) the
announcement of a merger of the Company with another company. The agreement with
Dr. Stote also provides that, upon termination  following a change in control of
the  Company,  Dr.  Stote shall be  entitled to receive (i) a severance  payment
equal to 2.99 times his average  annual  salary  plus  bonuses for the five year
period preceding the year in which the change in control occurs,  or that amount
of salary that would have been due to Dr. Stote  through the  expiration  of the
term of this  Agreement,  whichever is greater,  (ii) a number of stock  options
equal to the number of stock  options held by Dr.  Stote prior to the  effective
date of such change in control  (the  "Termination  Options"),  (iii)  immediate
vesting of all outstanding  stock options  (including the Termination  Options),
and (iv) health and other benefits through the end of the term of the agreement.
Pursuant to the  agreement,  if  terminated  without  cause,  Dr.  Stote will be
entitled to a severance  payment equal to 2.99 times the average of Dr.  Stote's
salary plus bonus for the five year period  preceding the year in which the date
of termination  occurs and immediate  vesting of all outstanding  non-plan stock
options.

         Mr.  Michael  D.  Price,  Vice  President,   Chief  Financial  Officer,
Secretary and Treasurer,  entered into an employment  agreement with the Company
dated as of July 1, 1998 and under the  terms of its  amendment  provides  for a
term which  expires on June 30,  2001.  Under the terms of this  agreement,  Mr.
Price's  current  annual base salary is $194,381.  The agreement  with Mr. Price
also  provides  for  bonuses  at  the   recommendation  and  discretion  of  the
Compensation  Committee  of the  Company's  Board  of  Directors.  Mr.  Price is
eligible for a bonus upon (i) the  attainment by the Company of two  consecutive
quarters of net profit,  (ii) the closing of a year with a net profit,  or (iii)
the  announcement  of a merger of the Company into another  Company or a sale or
transfer  of  all of  substantially  all of  the  pharmaceutical  assets  of the
Company.  Mr.  Price is entitled  to a bonus of 50% of his annual  salary upon a
change in control of the Company.  The  agreement  with Mr. Price also  provides
that, upon termination  following a change in control of the Company,  Mr. Price
shall be  entitled to receive  (i) a  severance  payment  equal to 2.9 times his
annual salary plus bonuses, or that amount of salary and bonuses that would have
been due to Mr.  Price  through  the  expiration  of the term of the  agreement,
whichever  is  greater,  (ii) a number of stock  options  equal to the number of
stock  options held by Mr. Price prior to the  effective  date of such change in
control (the "Termination Options"),  (iii) immediate vesting of all outstanding
stock options  (including the  Termination  Options),  and (iv) health and other
benefits  through  the  end  of  the  term  of the  agreement.  Pursuant  to the
agreement,  if  terminated  without  cause,  Mr.  Price  will be  entitled  to a
severance  payment equal to one year of salary plus bonus and immediate  vesting
of all outstanding non-plan stock options.

         Mr. Robert J. Gyurik,  Vice  President of  Pharmaceutical  Development,
entered into an employment  agreement with the Company dated as of March 9, 1999
providing  for an initial term which  expires on December  31,  2001.  Under the
terms of this agreement,  Mr.  Gyurik's  current annual base salary is $145,530.
Under the  agreement,  Mr.  Gyurik  received a sign-on bonus of 40,000 shares of
Common Stock.  The agreement  with Mr. Gyurik also provides for bonuses of up to
50% of his annual  salary  each  year,  based upon the  attainment  of  research
collaborations,  at  the  recommendation  and

                                       15





discretion of the  Compensation  Committee of the Company's  Board of Directors.
Mr.  Gyurik is  eligible  for a bonus upon the  announcement  of a merger of the
Company into another Company or a sale or transfer of all or  substantially  all
of the assets of the  Company.  Mr.  Gyurik is entitled to a bonus of 50% of his
annual salary upon a change in control of the Company.  The  agreement  with Mr.
Gyurik also provides that, upon termination following a change in control of the
Company,  Mr. Gyurik shall be entitled to receive (i) a severance  payment equal
to 2.9 times his  annual  salary  plus  bonuses,  or that  amount of salary  and
bonuses that would have been due to Mr.  Gyurik  through the  expiration  of the
term of the  agreement,  whichever  is greater,  (ii) a number of stock  options
equal to the number of stock  options held by Mr.  Gyurik prior to the effective
date of such change in control  (the  "Termination  Options"),  (iii)  immediate
vesting of all outstanding  stock options  (including the Termination  Options),
and (iv) health and other benefits through the end of the term of the agreement.
Pursuant to the  agreement,  if  terminated  without  cause,  Mr. Gyurik will be
entitled  to a  severance  payment  equal to one year of salary  plus  bonus and
immediate vesting of all outstanding non-plan stock options.

         Mr. Jordan A. Horvath, Vice President and General Counsel, entered into
an employment  agreement  with the Company dated as of August 14, 2000 providing
for an initial term which expires on December 31, 2003.  Under the terms of this
agreement,  Mr. Horvath's current annual base salary is $304,500.  The agreement
with Mr. Horvath also provides for bonuses at the  recommendation and discretion
of the Compensation Committee of the Company's Board of Directors. The agreement
with Mr.  Horvath also provides  that,  upon  termination  following a change in
control of the Company, Mr. Horvath shall be entitled to receive (i) a severance
payment equal to 2.99 times his annual  salary plus  bonuses,  or that amount of
salary  and  bonuses  that  would  have  been  due to Mr.  Horvath  through  the
expiration of the term of the agreement,  whichever is greater, (ii) a number of
stock options equal to the number of stock options held by Mr.  Horvath prior to
the effective date of such change in control (the "Termination Options"),  (iii)
immediate  vesting of all  outstanding  stock  options  (including  equal to the
number of stock options held by Mr.  Horvath prior to the effective date of such
change in the Termination  Options),  and (iv) health and other benefits through
the end of the term of the agreement or for a period of five years, whichever is
greater.  Pursuant to the agreement,  if terminated  without cause,  Mr. Horvath
will be entitled to a severance  payment equal to two years of salary plus bonus
and immediate vesting of all outstanding non-plan stock options.

COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT

         Section  16(a) of the  Securities  Exchange  Act of 1934,  as  amended,
requires the Company's executive officers and directors, and any persons who own
more than 10% of any class of the Company's equity  securities,  to file certain
reports  relating  to their  ownership  of such  securities  and changes in such
ownership  with the  Securities  and Exchange  Commission,  the  American  Stock
Exchange and the Pacific  Stock  Exchange and to furnish the Company with copies
of such reports. To the Company's knowledge,  during the year ended December 31,
2000, all Section 16(a) filing requirements have been satisfied.

1991 STOCK OPTION PLAN

         The Company's 1991 Stock Option Plan (the "1991 Plan") was  unanimously
adopted  by the Board of  Directors  on  September  30,  1991,  approved  by the
stockholders at the December 1991 Annual Meeting of Stockholders  and amended to
increase  the  number of shares  available  under  the plan to an  aggregate  of
1,000,000 by the  stockholders  at the February 1993,  June 1994,  June 1997 and
June 1999 Annual  Meetings of  Stockholders.  The purpose of the 1991 Plan is to
promote the  interests  of the Company in  attracting  and  retaining  employees
(including  officers) and experienced and knowledgeable  non-employee  directors
for the Company and its subsidiaries,  by enabling them to acquire or increase a
proprietary  interest in the Company,  to benefit from appreciation in the value
of the Company's Common Stock and, thus,  participate in the long-term growth of
the Company.

                                       16




         During the fiscal year ended  December  31,  2000,  options to purchase
33,000  shares of Common  Stock were granted to employees of the Company who are
not executive  officers.  Such options were granted at prices ranging from $6.37
to $10.63 per share,  representing  the fair market value of the Common Stock on
the dates of grant. These options expire on various dates ranging from March 15,
2010 to October 2, 2010.

2001 EMPLOYEE STOCK OPTION PLAN

         The Company's 2001 Employee Stock Option Plan was  unanimously  adopted
by the Board of Directors on March 30,  2001,  and is presented  for approval by
the  stockholders at the Meeting.  See "Proposal 2." The purpose of this plan is
to promote the  interests of the Company in attracting  and retaining  employees
(including  employees  who are officers and  directors)  for the Company and its
subsidiaries,  by enabling them to acquire or increase a proprietary interest in
the Company,  to benefit from  appreciation in the value of the Company's Common
Stock and, thus, participate in the long-term growth of the Company.

2001 DIRECTORS' STOCK OPTION PLAN

         The Company's 2001 Directors' Stock Option Plan was unanimously adopted
by the Board of Directors on March 30,  2001,  and is presented  for approval by
the  stockholders at the Meeting.  See "Proposal 3." The purpose of this plan is
to promote the interests of the Company in attracting and retaining  experienced
and  knowledgeable  non-employee  directors  for the Company by enabling them to
acquire or increase a  proprietary  interest  in the  Company,  to benefit  from
appreciation in the value of the Company's  Common Stock and, thus,  participate
in the long-term growth of the Company.

401(K) RETIREMENT PLAN

         The Company sponsors a 401(k) retirement plan (the "401(k) Plan") under
which eligible employees may contribute,  on a pre-tax basis,  between 1% to 15%
of their  respective  total annual  income from the Company,  subject to maximum
aggregate annual  contribution  imposed by the Internal Revenue Code of 1986, as
amended (the "Code").  All  full-time  employees who work for the Company in the
U.S. are eligible to participate in the 401(k) Plan. All employee  contributions
are allocated to the employee's  individual  account and are invested in various
investment  options as directed by the employee.  Cash  contributions  are fully
vested and  nonforfeitable.  The Company made matching cash contributions to the
401(k)  Plan for the 2000 fiscal year in the amount of $2,426 and in the form of
7,017 shares of the  Company's  Common  Stock valued at $57,446.  The Company is
currently  matching 100% of each eligible  employee's  contribution in 2001 with
shares of the Company's Common Stock.

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         The Company provided loans to each of Messrs. Murphy, Price and Gyurik,
in the amounts of $250,000, $50,000 and $140,000,  respectively,  in March 2000,
which  Messrs.  Murphy,  Price  and  Gyurik  used to pay  the  income  taxes  on
equity-based  compensation  received  in the prior year.  The loans,  which bear
interest  at 6.59%  annually,  mature in March  2003 and are  secured by 28,000,
6,000 and 16,000 shares of the Company's  Common Stock owned by Messrs.  Murphy,
Price and Gyurik, respectively. Interest on the loans accrues quarterly.

                                       17




AUDIT COMMITTEE REPORT

         In  accordance  with its  charter  adopted  by the  Board of  Directors
(attached as Appendix A), the Audit  Committee  assists the Board in  fulfilling
its  responsibilities  relating  to the  Company's  audited  financial  reports,
accounting  procedures and financial  controls.  The Audit Committee reviews the
procedures  and results of the  Company's  independent  audits,  and  provides a
direct  communications  link to the Board of Directors  from  Deloitte & Touche,
LLP, the  Company's  independent  auditors,  and the Company's  chief  financial
officer to help  assure the quality of the  Company's  financial  reporting  and
control systems.

         During 2000, the Audit Committee met two times and the committee chair,
as  representative  of the committee,  began holding  discussions with the chief
financial  officer and  independent  auditors  regarding  the interim  financial
information  contained in the Company's  quarterly reports on Form 10-Q prior to
filing with the Securities and Exchange Commission.

         AUDITOR  INDEPENDENCE AND 2000 AUDIT. To fulfill its duties,  the Audit
Committee  obtained  a  formal  written  report  of  the  independent   auditors
describing  all  relationships  between the  auditors and the Company that might
bear on the auditors' independence  consistent with Independence Standards Board
Standard No. 1,  "Independence  Discussions with Audit  Committee." In addition,
the Audit  Committee  discussed  with the  auditors any  relationships  that may
impact  their  objectivity  and  independence  and  satisfied  itself  as to the
auditors'  independence.  The Audit Committee also discussed with management and
the  independent  auditors  the quality and adequacy of the  Company's  internal
controls. The Audit Committee reviewed with the independent auditors their audit
plans, audit scope and identification of audit risks.

         The  Audit  Committee  discussed  and  reviewed  with  the  independent
auditors all communications  required by generally accepted auditing  standards,
including those described in Statement on Auditing Standards No. 61, as amended,
"Communication with Audit Committee" and reviewed the results of the independent
auditors' examination of the financial statements.

         2000 FINANCIAL  STATEMENTS AND  RECOMMENDATIONS  OF THE COMMITTEE.  The
Audit Committee  reviewed the Company's audited  financial  statements as of and
for the year  ended  December  31,  2000  with  management  and the  independent
auditors. Management has the responsibility for the preparation of the Company's
financial  statements and the independent  auditors have the  responsibility for
the examination of those statements.

         Based on the review discussed above and discussions with management and
the  independent  auditors,  the  Audit  Committee  recommended  to the Board of
Directors  that the Company's  audited  financial  statements be included in the
Company's  Annual  Report on Form10-K  for the year ended  December 31, 2000 for
filing with the Securities and Exchange Commission.

         AUDIT  FEES.  The  aggregate  fees  billed  for  professional  services
rendered by the  independent  auditors for the audit of the Company's  financial
statements as of and for the year ended  December 31, 2000 and the review of the
financial  statements  in the  Company's  Form  10-Q  filings  for the year were
$80,000.

         ALL OTHER FEES. The aggregate fees billed by the  independent  auditors
during 2000 for  non-audit and  non-information  systems  related  services were
$30,000.  These services  consisted of tax consultation,  tax compliance and tax
research  services.  The  independent  auditors  did  not  provide  professional
services during 2000 for the operation of the Company's  information  systems or
financial  system  design and  implementation.  The Audit  Committee  considered
whether,  and has determined that, the provision of these services is compatible
with maintaining the independent auditors' independence.

                                       18



DISCLAIMER

         This report is being provided to the Company's  stockholders solely for
informational  purposes.  You should not consider this report to be  "soliciting
material"  or to be "filed"  with the SEC.  It also is not  subject to the SEC's
proxy rules or to the  liabilities of Section 18 of the U.S.  Security  Exchange
Act of 1934. In addition,  this report shall not be deemed to be incorporated by
reference  into any prior or subsequent  filing by the Company under the Federal
securities laws.

                                 AUDIT COMMITTEE
                                 William Packer, Chairman
                                 Charles L. Bolling
                                 Miguel Fernandez

                                       19



COMPENSATION COMMITTEE REPORT

         The  Compensation  Committee  of  the  Board  of  Directors,  which  is
currently comprised of all non-employee Directors of the Company, determines, to
the extent not fixed pursuant to the terms of applicable employment  agreements,
the compensation of the Chief Executive  Officer,  other employee members of the
Board of Directors,  and all other executive employees whose annual compensation
exceeds  $100,000.  The  compensation  levels of such  officers,  Directors  and
employees are subject to the approval of the Board of Directors.

         The  Compensation  Committee,  being  responsible  for  overseeing  and
approving  executive  compensation and grants of stock options, is in a position
to appropriately  balance the current cash compensation  considerations with the
longer-range incentive-oriented growth outlook associated with stock options.

         The main  objectives of the Company's  compensation  structure  include
rewarding  individuals  for  their  respective  contributions  to the  Company's
performance,  providing executive officers with a stake in the long-term success
of the  Company and  providing  compensation  programs  and  policies  that will
attract,  retain  and  motivate  qualified  executive  personnel.  The  Board of
Directors  and the  Compensation  Committee  place a great deal of importance on
recruiting,   hiring,  retaining  and  motivating  high  quality  personnel  and
recognize  that by offering  executives  employment  agreements,  it can be more
successful  in  recruiting  experienced   executives  from  large,   established
pharmaceutical  companies.  Historically,  the members of the Board of Directors
and the Compensation  Committee have chosen to achieve these objectives  through
salary  increases,  bonuses and periodic  stock  option  grants.  The  Committee
considered each of these factors in approving the  compensation  for Mr. Murphy,
who serves as President and Chief Executive Officer.

         In determining  compensation,  the  Compensation  Committee  considers,
among other things,  the  performance  of the Company,  improvement in financial
position,  strategic alliances,  acquisition of products,  product registration,
raising of  capital,  compensation  levels in  competing  companies,  individual
contributions  to the Company and the length of service  with the  Company.  The
Compensation   Committee  also  surveyed  executive  compensation  of  similarly
situated  companies  and  retained  the  services  of an  independent  law firm,
experienced in employment and compensation matters, for the purpose of obtaining
independent,  objective guidance with respect to the Committee's  performance of
its duties.

         Compensation  through  the  periodic  grant of  Common  Stock and stock
options  under the  Company's  stock  option  plans is  intended  to  coordinate
executives'  and  stockholders'  long-term  interests  by creating a direct link
between a portion of executive compensation and increases in the price of Common
Stock and the long-term success of the Company. This method of compensation also
permits the Company to preserve its cash resources.

         For the year 2000, Mr.  Murphy,  recommended  merit  increases and base
salary  amounts for each officer other than himself  based on his  assessment of
each  officer's  individual  performance  and  accomplishment  of corporate  and
personal objectives.  We evaluated Mr. Murphy's  recommendations  regarding each
officer's  compensation,  taking  into  account  the  officer's  tenure  and our
subjective  assessment of individual  performance.  We considered  Mr.  Murphy's
recommendations  with respect to merit  increases  and base salary  amounts.  We
reviewed the  accomplishments  and  performance of such officers and comparative
compensation  data  from  similar  or  competing  companies  and  then  approved
compensation packages for each of the Company's officers.

         A significant  portion of the direct  compensation of officers consists
of annual  incentive  bonuses.  Bonus  targets are closely  tied to  performance
measures, at both the corporate level and at individual areas

                                       20



of  responsibility.  Mr. Murphy  recommended  specific  bonuses for all officers
other than himself.  We evaluated Mr.  Murphy's  recommendations  regarding each
officer's bonus,  taking into account Mr. Murphy's  assessment of each officer's
individual performance and our subjective assessment of individual  performance,
in addition to  accomplishment  of corporate  objectives.  We then  approved the
bonuses to be awarded for the calendar year 2000.

         Future  increases  in  executive  compensation  will be based  upon the
satisfaction of pre-established individual objectives,  extraordinary individual
contributions, corporate milestones and financial performance of the Company.

DISCLAIMER

         This report is being provided to the Company's  stockholders solely for
informational  purposes.  You should not consider this report or the stock price
performance  graph that follows to be  "soliciting  materials"  or to be "filed"
with  the  SEC.  They  are  not  subject  to the  SEC's  proxy  rules  or to the
liabilities  of  Section  18 of the  U.S.  Security  Exchange  Act of  1934.  In
addition,  this  report  and the  performance  graph  shall  not be deemed to be
incorporated  by reference  into any prior or  subsequent  filing by the Company
under the Federal securities laws.

                                                  COMPENSATION COMMITTEE
                                                  Michael McGovern, Chairman
                                                  Charles L. Bolling
                                                  Russell Cleveland
                                                  Miguel Fernandez
                                                  William Packer



                                       21




COMMON STOCK PERFORMANCE

         The graph  presented  below compares the cumulative  total  stockholder
return on the Company's  Common Stock for the five years ended December 31, 2000
with the cumulative  total  stockholder  return for such period reflected in the
Standard  and Poor's  (S&P) 500 Stock  Index and in a peer group  index of three
competing  pharmaceutical  companies  (Dura  Pharmaceuticals,   Inc.,  MacroChem
Coporation  and  Noven  Pharmaceuticals,  Inc.  The graph  (and the  information
relating to it) was obtained by the Company from S&P.  The  comparative  returns
shown in the graph assume (i) the  investment  of $100 in the  Company's  Common
Stock, the common stock of the companies included in the S&P 500 Stock Index and
the common  stock of the  companies  in the peer  group at the  market  close on
December 31, 1995 and (ii) the reinvestment of all dividends.




                              [GRAPH APPEARS HERE]









                                       22





                            TOTAL SHAREHOLDER RETURNS
                            -------------------------
                             (Dividends Reinvested)




                                                                        ANNUAL RETURN PERCENTAGE
                                                                              Years Ending
Company Name/Index                                        Dec 96      Dec 97     Dec 98       Dec 99         Dec 00
--------------------------------------------------------------------------------------------------------------------
                                                                                               
BENTLEY PHARMACEUTICALS                                    16.67       -9.52     -36.84       312.53          -5.06
S&P 500 INDEX                                              22.96       33.36      28.58        21.04          -9.10
NEW PEER GROUP                                            126.68       -7.33     -59.35        12.55          78.08







                                                                                       INDEXED RETURNS
                                                       Base                              Years Ending
                                                      Period
Company Name/Index                                    Dec 95         Dec 96      Dec 97     Dec 98       Dec 99         Dec 00
-------------------------------------------------------------------------------------------------------------------------------
                                                                                                      

BENTLEY PHARMACEUTICALS                                 100          116.67      105.56      66.67       275.02         261.11
S&P 500 INDEX                                           100          122.96      163.98     210.85       255.21         231.98
PEER GROUP                                              100          226.68      210.07      85.39        96.10         171.14






Peer Group Companies
--------------------
DURA PHARMACEUTICALS, INC.
MACROCHEM CORPORATION
NOVEN PHARMACEUTICALS, INC.



                                       23




                                   PROPOSAL 2

            APPROVAL OF THE COMPANY'S 2001 EMPLOYEE STOCK OPTION PLAN

         On  March  30,  2001,  the  Board  of  Directors  adopted,  subject  to
stockholder  approval at the Meeting,  the Company's  2001 Employee Stock Option
Plan. The 2001 Employee Stock Option Plan is herein referred to as the "Employee
Plan". The Employee Plan is designed to provide an incentive to key employees of
the Company and to offer an  additional  inducement in obtaining the services of
such persons.  The proceeds  derived from the sale of shares  subject to options
will be used for general corporate purposes of the Company.

         The Employee Plan is being  proposed at this time due to the expiration
of the 1991 Plan on September 30, 2001.

         The following summary of certain material features of the Employee Plan
does not purport to be complete and is qualified in its entirety by reference to
the text of the  Employee  Plan,  a copy of which is set forth as  Appendix B to
this Proxy Statement.

SHARES SUBJECT TO THE EMPLOYEE PLAN AND ELIGIBILITY

         The Employee Plan authorizes the grant of options to purchase a maximum
of 1,000,000  shares of the  Company's  Common Stock  (subject to  adjustment as
described  below)  to  employees  (including  officers  and  directors  who  are
employees) of the Company.  Upon  expiration,  cancellation  or  termination  of
unexercised  options,  the shares of the Company's  Common Stock subject to such
options  will again be  available  for the grant of options  under the  Employee
Plan.  All of the  employees  of the Company are  currently  eligible to receive
grants of options under the Employee Plan.

         No options have been granted under the Employee Plan.

         On March  30,  2001,  the high and low sales  prices  of the  Company's
Common Stock as reported by the American Stock Exchange were $4.55 and $4.80 per
share, respectively.

TYPE OF OPTIONS

         Options  granted under the Employee Plan may either be incentive  stock
options ("ISOs"), within the meaning of Section 422 of the Code, or nonqualified
stock options which do not qualify as ISOs ("NQSOs").

ADMINISTRATION

         The Employee Plan will be administered by the compensation committee of
the Board of Directors (the  "Committee")  consisting of at least two members of
the Board, each of whom is a "non-employee  director" within the meaning of Rule
16b-3 promulgated under the Securities Exchange Act of 1934. It is also intended
that each  member of the  Committee  will be an  "outside  director"  within the
meaning of Section 162(m) of the Code. The current  members of the Committee are
Michael  McGovern  (chairman),   Charles  Bolling,  Russell  Cleveland,   Miguel
Fernandez and William Packer.


                                       24



         Among other things, the Committee is empowered to determine, within the
express  limits  contained in the  Employee  Plan:  the  employees to be granted
options, the times when options shall be granted,  whether an option is to be an
ISO or a NQSO,  the  number  of shares of  Common  Stock to be  subject  to each
option,  the exercise  price of each option,  the term of each option,  the date
each  option  shall  become  exercisable  as well as any  terms,  conditions  or
installments  relating to the  exercisability of each option,  whether and under
what conditions to accelerate the date of exercise of any option or installment,
the form of payment of the exercise price,  the amount,  if any,  required to be
withheld  with respect to an option and,  with the consent of the  optionee,  to
modify an option.  The  Committee is also  authorized  to  prescribe,  amend and
rescind  rules and  regulations  relating to the  Employee  Plan and to make all
other determinations  necessary or advisable for administering the Employee Plan
and to construe the Employee Plan.

TERMS AND CONDITIONS OF OPTIONS

         Options granted under the Employee Plan will be subject to, among other
things, the following terms and conditions:

(a) The  exercise  price of each option  will be  determined  by the  Committee;
provided,  however, that the exercise price of an ISO, or of any option intended
to  satisfy  the  performance-based  compensation  exemption  to  the  deduction
limitation  under Section  162(m) of the Code, and may not be less than the fair
market  value of the  Company's  Common Stock on the date of grant (110% of such
fair market  value if the  optionee  owns (or is deemed to own) more than 10% of
the voting power of the Company).

(b) Options  may be granted for terms  determined  by the  Committee;  provided,
however,  that  the  term of an ISO may not  exceed  10  years  (5  years if the
optionee  owns (or is deemed to own)  more than 10% of the  voting  power of the
Company).

(c) The maximum number of shares of the Company's Common Stock for which options
may be granted to an employee in any calendar year is 250,000. In addition,  the
aggregate  fair market value of shares with respect to which ISOs may be granted
to an employee which are exercisable for the first time during any calendar year
may not exceed $100,000.

(d) The  exercise  price of each option is payable in full upon  exercise or, if
the applicable  stock option contract  ("Contract")  entered into by the Company
with an optionee permits,  in installments.  Payment of the exercise price of an
option  may be made in cash,  certified  check  or, if the  applicable  Contract
permits,  in previously  acquired shares of the Company's Common Stock having an
aggregate  fair market  value on the date of  exercise,  equal to the  aggregate
exercise price of all options being exercised,  or any combination  thereof. The
Committee may, in its sole  discretion,  permit payment of the exercise price of
an option by delivery by the optionee of a properly  executed  notice,  together
with a copy of the optionee's irrevocable instructions to a broker acceptable to
the  Committee,  to deliver  promptly  to the Company the amount of sale or loan
proceeds sufficient to pay the exercise price.

(e) Options may not be transferred  other than by will or by the laws of descent
and  distribution,  and may be exercised during the optionee's  lifetime only by
the optionee or his or her legal representatives.

(f) Except as may  otherwise  be provided  in the  applicable  Contract,  if the
optionee's  relationship  with the Company as an employee is terminated  for any
reason (other than the death,  disability or  retirement of the  optionee),  the
option may be exercised, to the extent exercisable at the time of termination of
such  relationship,  within three months  thereafter,  but in no event after the
expiration of the term of the option. If the employee is terminated  following a
change of control of the Company,  the employee may exercise

                                       25



all  options  whether  or not  they  had  become  exercisable.  However,  if the
relationship  is  terminated  either  for cause or  without  the  consent of the
Company, the option will terminate  immediately.  In the case of the death of an
optionee while an employee (or, generally, within three months after termination
of such relationship,  or within one year after termination of such relationship
by reason of disability  or  (retirement),  except as otherwise  provided in the
Contract,  his or her legal  representative  or  beneficiary  may  exercise  the
option,  to the extent  exercisable on the date of death,  within one year after
such  date,  but in no event  after the  expiration  of the term of the  option.
Except as otherwise  provided in the Contract,  an optionee  whose  relationship
with the Company was terminated by reason of his or her disability or retirement
may  exercise  the  option,  to the  extent  exercisable  at the  time  of  such
termination,  within one year  thereafter,  but not after the  expiration of the
term of the  option.  Options  are not  affected by a change in the status of an
optionee so long as he or she continues to be an employee of the Company.

(g) The Company may withhold cash and/or  shares of the  Company's  Common Stock
having an aggregate  value equal to the amount which the Company  determines  is
necessary to meet its  obligations  to withhold any federal,  state and/or local
taxes or other amounts incurred by reason of the grant or exercise of an option,
its  disposition or the  disposition of shares acquired upon the exercise of the
option.  Alternatively,  the Company may require the optionee to pay the Company
such amount, in cash, promptly upon demand.

ADJUSTMENT IN EVENT OF CAPITAL CHANGES

         Appropriate  adjustments  will be made in the number and kind of shares
available  under the Employee  Plan, in the number and kind of shares subject to
each outstanding option and the exercise prices of such options,  as well as the
number of shares  subject to future  grants to optionees  and  limitation on the
number of shares that may be granted to any  employee in any calendar  year,  in
the event of any  change in the  Company's  Common  Stock by reason of any stock
dividend, split-up, spin off, combination,  reclassification,  recapitalization,
merger in which the Company is not the surviving corporation, exchange of shares
or the like. In the event of (a) the  liquidation or dissolution of the Company,
or (b) a merger in which  the  Company  is not the  surviving  corporation  or a
consolidation,  the Board of Directors of the Company  shall,  as to outstanding
options,  either (i) make appropriate  provisions for the protection of any such
outstanding  options by the  substitution  on an equitable  basis of appropriate
stock of the Company or of the merged,  consolidated  or  otherwise  reorganized
corporation  which will be issuable  in respect to one share of Common  Stock of
the Company;  provided,  only that the excess of the aggregate fair market value
of the shares subject to the options  immediately  after such  substitution over
the purchase  price  thereof is not more than the excess of the  aggregate  fair
market  value of the shares  subject to such  options  immediately  before  such
substitution over the purchase price thereof,  or (ii) upon written notice to an
optionee,  provide  that all  unexercised  options  must be  exercised  within a
specified  number of days of the date of such notice or they will be terminated.
In any such case,  the Board of Directors  may, in its  discretion,  advance the
lapse of any waiting or installment periods and exercise dates.

DURATION AND AMENDMENT OF THE EMPLOYEE PLAN

         No option may be granted  under the Employee Plan after March 30, 2011.
The Board of Directors  may at any time  terminate  or amend the Employee  Plan;
provided, however, that, without the approval of the Company's stockholders,  no
amendment  may be made which  would (a) except as a result of the  anti-dilution
adjustments described above, increase the maximum number of shares available for
the grant of options  or  increase  the  maximum  number of options  that may be
granted  to an  employee  in any  calendar  year,  (b)  change  the  eligibility
requirements  for persons  who may  receive  options or (c) make any changes for
which applicable law or regulatory authority requires stockholder  approval.  No

                                       26




termination  or amendment  may  adversely  affect the rights of an optionee with
respect to an outstanding option without the optionee's consent.

FEDERAL INCOME TAX TREATMENT

         The following is a general summary of certain  material  federal income
tax  consequences  of the grant and  exercise of the options  under the Employee
Plan and the  sale of any  underlying  security.  This  description  is based on
current law, which is subject to change,  possibly with retroactive effect. This
discussion  does not purport to address all tax  considerations  relating to the
grant and exercise of the options or resulting  from the  application of special
rules to a particular  optionee  (including an optionee subject to the reporting
and short-swing  profit  provisions under Section 16 of the Securities  Exchange
Act of 1934, as amended),  and state, local,  foreign and other tax consequences
inherent in the  ownership  and exercise of stock  options and the ownership and
disposition  of any  underlying  security.  An optionee  should consult with the
optionee's own tax advisors with respect to the tax consequences inherent in the
ownership and exercise of stock options and the ownership and disposition of any
underlying security.

ISOS EXERCISED WITH CASH

         No taxable  income will be  recognized by an optionee upon the grant or
exercise of an ISO. The  optionee's  tax basis in the shares  acquired  upon the
exercise  of an ISO with cash will be equal to the  exercise  price  paid by the
optionee for such shares.

         If the shares  received  upon  exercise of an ISO are  disposed of more
than one year after the date of transfer of such shares to the optionee and more
than two years from the date of grant of the option, the optionee will recognize
long-term  capital  gain or loss on such  disposition  equal  to the  difference
between  the  selling  price and the  optionee's  basis in the  shares,  and the
Company will not be entitled to a deduction. Long-term capital gain is generally
subject to more favorable tax treatment than short-term capital gain or ordinary
income.

         If the shares  received  upon the  exercise  of an ISO are  disposed of
prior  to the  end of the  two-years-from-grant/one-year-after-transfer  holding
period (a "disqualifying  disposition"),  the excess (if any) of the fair market
value of the shares on the date of transfer of such shares to the optionee  over
the  exercise  price (but not in excess of the gain  realized on the sale of the
shares) will be taxed as ordinary  income in the year of such  disposition,  and
the Company generally will be entitled to a deduction in the year of disposition
equal to such amount. Any additional gain or any loss recognized by the optionee
on such disposition will be short-term or long-term capital gain or loss, as the
case may be, depending upon the period for which the shares were held.

NQSOS EXERCISED WITH CASH

         No taxable  income will be  recognized by an optionee upon the grant of
an NQSO.  Upon the  exercise of an NQSO,  the excess of the fair market value of
the shares  received at the time of exercise  over the exercise  price  therefor
will be taxed as ordinary income,  and the Company will generally be entitled to
a corresponding  deduction. The optionee's tax basis in the shares acquired upon
the  exercise  of such  NQSO  will be equal to the  exercise  price  paid by the
optionee for such shares plus the amount of ordinary income so recognized.

         Any gain or loss recognized by the optionee on a subsequent disposition
of shares purchased  pursuant to an NQSO will be short-term or long-term capital
gain or loss,  depending  upon the period

                                       27




during which such shares were held, in an amount equal to the difference between
the selling price and the optionee's tax basis in the shares.

EXERCISES OF OPTIONS USING PREVIOUSLY ACQUIRED SHARES

         If  previously  acquired  shares  are  surrendered  in full or  partial
payment of the exercise price of an option  (whether an ISO or a NQSO),  gain or
loss  generally will not be recognized by the optionee upon the exercise of such
option to the extent the optionee  receives shares which on the date of exercise
have  a fair  market  value  equal  to  the  fair  market  value  of the  shares
surrendered in exchange therefor ("Replacement Shares"). If the option exercised
is an ISO or if the shares used were  acquired  pursuant  to the  exercise of an
ISO, the Replacement  Shares are treated as having been acquired pursuant to the
exercise of an ISO.

         However,  if an ISO is  exercised  with  shares  which were  previously
acquired  pursuant  to the  exercise  of an ISO but which  were not held for the
required two-years-from-grant/one-year-after-transfer holding period, there is a
disqualifying  disposition of such previously acquired shares. In such case, the
optionee would recognize ordinary income on such disqualifying disposition equal
to the  difference  between the fair market  value of such shares on the date of
exercise of the prior ISO and the amount paid for such shares (but not in excess
of the gain  realized).  Special  rules apply in  determining  which  shares are
considered  to have been  disposed  of and in  allocating  the  basis  among the
shares. No capital gain is recognized.

         The optionee  will have an aggregate  basis in the  Replacement  Shares
equal to the basis of the shares  surrendered,  increased by any ordinary income
required to be recognized on the disposition of the previously  acquired shares.
The optionee's  holding period for the Replacement Shares generally includes the
period during which the surrendered shares were held.

         Any shares received by the optionee on such exercise in addition to the
Replacement  Shares will be treated in the same manner as a cash  exercise of an
option for no consideration.

ALTERNATIVE MINIMUM TAX

         In addition to the federal income tax consequences  described above, an
optionee  who  exercises an ISO may be subject to the  alternative  minimum tax,
which is payable  only to the  extent it  exceeds  the  optionee's  regular  tax
liability. For this purpose, upon the exercise of an ISO, the excess of the fair
market  value of the shares  over the  exercise  price is an  adjustment,  which
increases the optionee's  alternative  minimum taxable income. In addition,  the
optionee's  basis in such shares is  increased  by such  amount for  purposes of
computing the gain or loss on disposition of the shares for alternative  minimum
tax purposes. If the optionee is required to pay an alternative minimum tax, the
amount of such tax which is attributable to deferral preferences  (including the
ISO adjustment) is allowable as a tax credit against the optionee's  regular tax
liability  (net of other  non-refundable  credits) in subsequent  years.  To the
extent the credit is not used, it is carried forward. An optionee holding an ISO
should consult with the optionee's tax advisors concerning the applicability and
effect of the alternative minimum tax.

                                       28



                                   PROPOSAL 3

           APPROVAL OF THE COMPANY'S 2001 DIRECTORS' STOCK OPTION PLAN

         On  March  30,  2001,  the  Board  of  Directors  adopted,  subject  to
stockholder  approval at the Meeting, the Company's 2001 Directors' Stock Option
Plan.  The 2001  Directors'  Stock  Option  Plan is  herein  referred  to as the
"Directors'  Plan".  The Directors'  Plan is designed to provide an incentive to
key non-employee  directors of the Company and to offer an additional inducement
in obtaining the services of such persons. The proceeds derived from the sale of
shares  subject to options  will be used for general  corporate  purposes of the
Company.

         The  Directors'  Plan  is  being  proposed  at  this  time  due  to the
expiration of the 1991 Plan on September 30, 2001.

         The following  summary of certain  material  features of the Directors'
Plan does not  purport  to be  complete  and is  qualified  in its  entirety  by
reference  to the text of the  Directors'  Plan, a copy of which is set forth as
Appendix C to this Proxy Statement.

         For a description of the current practice of the Company  regarding the
award of  options to  non-employee  directors,  see  "Proposal  1 - Election  of
Directors - Remuneration of Non-Employee Directors."

SHARES SUBJECT TO THE DIRECTORS' PLAN AND ELIGIBILITY

         The  Directors'  Plan  authorizes  the grant of options  to  purchase a
maximum of 500,000  shares of the Company's  Common Stock (subject to adjustment
as described below) to non-employee  directors of the Company.  Upon expiration,
cancellation or termination of unexercised  options, the shares of the Company's
Common Stock  subject to such  options will again be available  for the grant of
options under the  Directors'  Plan.  All of the  non-employee  directors of the
Company are currently eligible to receive grants of options under the Directors'
Plan.

         No options have been granted under the Directors' Plan.

         On March  30,  2001,  the high and low sales  prices  of the  Company's
Common Stock as reported by the American Stock Exchange were $4.55 and $4.80 per
share, respectively.

TYPE OF OPTIONS

         Options granted under the Directors'  Plan shall be nonqualified  stock
options  ("NQSOs")  which do not qualify as incentive  stock  options  ("ISOs"),
within the meaning of Section 422 of the Code (the "Code").

ADMINISTRATION

         The Directors' Plan will be administered by the compensation  committee
of the Board of Directors (the  "Committee")  consisting of at least two members
of the Board,  each of whom is a "non-employee  director"  within the meaning of
Rule 16b-3  promulgated  under the Securities  Exchange Act of 1934. The current
members of the  Committee  are Michael  McGovern  (chairman),  Charles  Bolling,
Russell Cleveland, Miguel Fernandez and William Packer.

                                       29




         Among other things, the Committee is empowered to determine, within the
express  limits  contained in the  Directors'  Plan: the directors to be granted
options, the times when options shall be granted, the number of shares of Common
Stock to be subject to each option,  the exercise price of each option, the term
of each option,  the date each option shall  become  exercisable  as well as any
terms, conditions or installments relating to the exercisability of each option,
whether  and under what  conditions  to  accelerate  the date of exercise of any
option or installment, the form of payment of the exercise price, the amount, if
any,  required to be withheld with respect to an option and, with the consent of
the  optionee,  to  modify  an  option.  The  Committee  is also  authorized  to
prescribe,  amend and rescind rules and  regulations  relating to the Directors'
Plan  and  to  make  all  other   determinations   necessary  or  advisable  for
administering the Directors' Plan and to construe the Directors' Plan.

TERMS AND CONDITIONS OF OPTIONS

         Options  granted  under the  Directors'  Plan will be subject to, among
other things, the following terms and conditions:

(a) The exercise  price of each option will be  determined  by the Committee but
may not be less than the fair market value of the Company's  Common Stock on the
date of grant.

(b) Options  may be granted for terms  determined  by the  Committee;  provided,
however, that the term may not exceed 10 years.

(c) The  exercise  price of each option is payable in full upon  exercise or, if
the applicable  stock option contract  ("Contract")  entered into by the Company
with an optionee permits,  in installments.  Payment of the exercise price of an
option  may be made in cash,  certified  check  or, if the  applicable  Contract
permits,  in previously  acquired shares of the Company's Common Stock having an
aggregate  fair market  value on the date of  exercise,  equal to the  aggregate
exercise price of all options being exercised,  or any combination  thereof. The
Committee may, in its sole  discretion,  permit payment of the exercise price of
an option by delivery by the optionee of a properly  executed  notice,  together
with a copy of the optionee's irrevocable instructions to a broker acceptable to
the  Committee,  to deliver  promptly  to the Company the amount of sale or loan
proceeds sufficient to pay the exercise price.

(d) Options may not be transferred  other than by will or by the laws of descent
and  distribution,  and may be exercised during the optionee's  lifetime only by
the optionee or his or her legal representatives.

(e) Except as may  otherwise  be provided  in the  applicable  Contract,  if the
optionee's  relationship  with the Company as a director is  terminated  for any
reason (other than the death or disability of the  optionee),  the option may be
exercised,  to the  extent  exercisable  at the  time  of  termination  of  such
relationship,  within  three  months  thereafter,  but  in no  event  after  the
expiration  of the  term of the  option.  However,  if the  board  appoints  the
optionee as a director  emeritus,  the option will expire in accordance with its
terms,  not in three months.  If an optionee ceases to be a director  because of
his removal or failure to be nominated for  re-election to the board or due to a
termination of director  emeritus status,  within three years following a change
of control of the Company,  the optionee may exercise all options whether or not
they had become  exercisable.  However, if the relationship is terminated either
for cause or without  the  consent of the  Company,  the option  will  terminate
immediately.  In the case of the death of an  optionee  (or,  generally,  within
three months after  termination of such  relationship,  or within one year after
termination of such relationship by reason of disability or retirement),  except
as  otherwise  provided  in the  Contract,  his or her legal  representative  or
beneficiary  may exercise the option,  to the extent  exercisable on the date of
death,  within one year after such date, but in no event after the expiration of
the term of the  option.  Except  as  otherwise  provided  in the  Contract,  an
optionee whose  relationship with the Company

                                       30



was terminated by reason of his or her  disability  may exercise the option,  to
the  extent  exercisable  at the  time  of such  termination,  within  one  year
thereafter, but not after the expiration of the term of the option.

(f) The Company may withhold cash and/or  shares of the  Company's  Common Stock
having an aggregate  value equal to the amount which the Company  determines  is
necessary to meet its  obligations  to withhold any federal,  state and/or local
taxes or other amounts incurred by reason of the grant or exercise of an option,
its  disposition or the  disposition of shares acquired upon the exercise of the
option.  Alternatively,  the Company may require the optionee to pay the Company
such amount, in cash, promptly upon demand.

ADJUSTMENT IN EVENT OF CAPITAL CHANGES

         Appropriate  adjustments  will be made in the number and kind of shares
available under the Directors' Plan, in the number and kind of shares subject to
each outstanding option and the exercise prices of such options,  as well as the
number of shares  subject  to future  grants to  optionees,  in the event of any
change in the Company's Common Stock by reason of any stock dividend,  split-up,
spin off, combination,  reclassification,  recapitalization, merger in which the
Company is not the surviving corporation, exchange of shares or the like. In the
event of (a) the  liquidation or dissolution of the Company,  or (b) a merger in
which the Company is not the surviving corporation or a consolidation, the Board
of Directors of the Company shall,  as to outstanding  options,  either (i) make
appropriate provisions for the protection of any such outstanding options by the
substitution on an equitable basis of appropriate stock of the Company or of the
merged, consolidated or otherwise reorganized corporation which will be issuable
in respect to one share of Common Stock of the Company;  provided, only that the
excess of the aggregate  fair market value of the shares  subject to the options
immediately  after such substitution over the purchase price thereof is not more
than the excess of the aggregate fair market value of the shares subject to such
options immediately before such substitution over the purchase price thereof, or
(ii) upon written notice to an optionee,  provide that all  unexercised  options
must be exercised  within a specified  number of days of the date of such notice
or they will be terminated. In any such case, the Board of Directors may, in its
discretion, advance the lapse of any waiting or installment periods and exercise
dates.

DURATION AND AMENDMENT OF THE DIRECTORS' PLAN

         No option  may be granted  under the  Directors'  Plan after  March 30,
2011.  The Board of Directors may at any time  terminate or amend the Directors'
Plan;   provided,   however,   that,  without  the  approval  of  the  Company's
stockholders, no amendment may be made which would (a) except as a result of the
anti-dilution adjustments described above, increase the maximum number of shares
available for the grant of options, (b) change the eligibility  requirements for
persons who may receive options or (c) make any changes for which applicable law
or  regulatory  authority  requires  stockholder  approval.  No  termination  or
amendment  may  adversely  affect the rights of an optionee  with  respect to an
outstanding option without the optionee's consent.


                                       31



FEDERAL INCOME TAX TREATMENT

         The following is a general summary of certain  material  federal income
tax  consequences  of the grant and exercise of the options under the Directors'
Plan and the  sale of any  underlying  security.  This  description  is based on
current law, which is subject to change,  possibly with retroactive effect. This
discussion  does not purport to address all tax  considerations  relating to the
grant and exercise of the options or resulting  from the  application of special
rules to a particular  optionee  (including an optionee subject to the reporting
and short-swing  profit  provisions under Section 16 of the Securities  Exchange
Act of 1934, as amended),  and state, local,  foreign and other tax consequences
inherent in the  ownership  and exercise of stock  options and the ownership and
disposition  of any  underlying  security.  An optionee  should consult with the
optionee's own tax advisors with respect to the tax consequences inherent in the
ownership and exercise of stock options and the ownership and disposition of any
underlying security.

NQSOS EXERCISED WITH CASH

         No taxable  income will be  recognized by an optionee upon the grant of
an NQSO.  Upon the  exercise of an NQSO,  the excess of the fair market value of
the shares  received at the time of exercise  over the exercise  price  therefor
will be taxed as ordinary income,  and the Company will generally be entitled to
a corresponding  deduction. The optionee's tax basis in the shares acquired upon
the  exercise  of such  NQSO  will be equal to the  exercise  price  paid by the
optionee for such shares plus the amount of ordinary income so recognized.

         Any gain or loss recognized by the optionee on a subsequent disposition
of shares purchased  pursuant to an NQSO will be short-term or long-term capital
gain or loss,  depending  upon the period during which such shares were held, in
an amount equal to the  difference  between the selling price and the optionee's
tax basis in the shares.

EXERCISES OF OPTIONS USING PREVIOUSLY ACQUIRED SHARES

         If  previously  acquired  shares  are  surrendered  in full or  partial
payment of the exercise  price of an option,  gain or loss generally will not be
recognized  by the  optionee  upon the exercise of such option to the extent the
optionee  receives shares which on the date of exercise have a fair market value
equal to the fair market value of the shares  surrendered  in exchange  therefor
("Replacement Shares").

         The optionee  will have an aggregate  basis in the  Replacement  Shares
equal to the basis of the shares  surrendered,  increased by any ordinary income
required to be recognized on the disposition of the previously  acquired shares.
The optionee's  holding period for the Replacement Shares generally includes the
period during which the surrendered shares were held.

         Any shares received by the optionee on such exercise in addition to the
Replacement  Shares will be treated in the same manner as a cash  exercise of an
option for no consideration.

                                       32




                                  MISCELLANEOUS

VOTING REQUIREMENTS

         Directors  are elected by a plurality  of the votes cast at the Meeting
at which a quorum is present  (Proposal 1). The affirmative  vote of the holders
of a majority of the votes cast at the Meeting at which a quorum is present will
be required to approve the Employee Plan  (Proposal 2) and the  Directors'  Plan
(Proposal  3). For  purposes of  Proposals  1, 2 and 3,  abstentions  and broker
non-votes are not considered cast with respect to such proposals.

INDEPENDENT AUDITORS

         The Audit  Committee of the Board of Directors of the Company  selected
Deloitte & Touche LLP to serve as the  Company's  independent  auditors  for the
year  ended  December  31,  2000  and for the year  ending  December  31,  2001.
Representatives of Deloitte & Touche LLP plan to be present at the Meeting.

STOCKHOLDER PROPOSALS

         From time to time  stockholders may present proposals for consideration
at a meeting,  which may be proper subjects for inclusion in the proxy statement
and form of proxy related to that meeting.  Stockholder proposals intended to be
included in the  Company's  proxy  statement  and form of proxy  relating to the
Company's 2001 Annual Meeting of Stockholders must be received by the Company at
its office at 65 Lafayette Road,  North Hampton,  New Hampshire 03862 by January
9, 2002. Any such proposals,  as well as any questions relating thereto,  should
be directed to the Secretary of the Company at such address.

ADDITIONAL INFORMATION

         The cost of solicitation of Proxies,  including the cost of reimbursing
banks, brokers and other nominees for forwarding Proxy solicitation  material to
the beneficial owners of shares held of record by them and seeking  instructions
from such beneficial owners,  will be borne by the Company.  The Company has not
engaged a proxy solicitor to solicit proxies;  however, proxies may be solicited
without  extra  compensation  by certain  officers and regular  employees of the
Company. Proxies may be solicited by mail and, if determined to be necessary, by
telephone, telegraph or personal interview.

OTHER MATTERS

         Management  does not intend to bring  before the  Meeting  any  matters
other than those specifically described above and knows of no matters other than
the  foregoing  to come  before  the  Meeting.  If any other  matters or motions
properly  come before the Meeting,  it is the  intention of the persons named in
the  accompanying  Proxy to vote such Proxy in accordance with their judgment on
such matters or motions,  including any matters  dealing with the conduct of the
Meeting.

                                           By Order of the Board of Directors

                                           MICHAEL D. PRICE
                                           Secretary

North Hampton, NH
April 3, 2001


                                       33


                                                                      Appendix A

                             Audit Committee Charter

                          BENTLEY PHARMACEUTICALS, INC.

    ------------------------------------------------------------------------

Objectives
----------

         (1)      To  review  the   procedures  and  results  of  the  Company's
                  independent  auditing  function  and to act  as  necessary  on
                  behalf of the board of directors  between board  meetings with
                  respect to the Company's audited financial reports, accounting
                  procedures and financial controls.

         (2)      To  provide  a  direct  communications  link to the  board  of
                  directors  from the  Company's  independent  auditors  and the
                  chief financial officer, and to help assure the quality of the
                  Company's financial reporting and control systems.

Duties and Responsibilities
---------------------------

         The Audit Committee,  acting,  where applicable,  by unanimous consent,
shall have the following duties and responsibilities:

         (1)      Review the comments of the  independent  auditors with respect
                  to management's  internal control procedures and practices for
                  safeguarding  assets,  authorizing and recording  transactions
                  and complying with company policies.

         (2)      Approve any  significant  changes in the Company's  accounting
                  principles or financial reporting practices.

         (3)      Review the Company's audited or unaudited financial statements
                  including  those  contained in its annual  report on Form 10-K
                  before public distribution.

         (4)      Review the  annual  audit  plan of the  independent  auditors.
                  Ensure the receipt from the  independent  auditors of a formal
                  written statement  delineating all relationships  between such
                  auditors  and  the  Company,   consistent  with   Independence
                  Standards Board Standard 1; actively engage in a dialogue with
                  such auditors with respect to any disclosed  relationships  or
                  services that may impact the objectivity  and  independence of
                  such  auditors;  and take,  or  recommend  that the full board
                  take,  appropriate  action to ensure the  independence of such
                  outside auditors.

         (5)      Meet with the independent auditors prior to the release to the
                  general public of any earnings information for fiscal quarters
                  and year end.

         (6)      Acknowledge the independent auditor's ultimate  accountability
                  to  the  board  of  directors  and  the  Audit  Committee,  as
                  representatives of the shareholders.

         (7)      Review the Company's  organization to accomplish  management's
                  financial reporting and control responsibilities.

         (8)      Review  compliance  with  applicable  regulatory and financial
                  reporting requirements.

                                      A-1




         (9)      Conduct  such other  reviews as are  necessary or advisable to
                  discharge the foregoing responsibilities.

         (10)     Review and reassess,  on an annual basis, the adequacy of this
                  Audit Committee Charter.

         (11)     Acknowledge the Audit  Committee's  responsibility  to select,
                  evaluate,   and,  where  appropriate,   replace  the  firm  of
                  independent auditors and to recommend annually to the board of
                  directors  the firm of  independent  auditors  to examine  the
                  Company's financial statements.

         (12)     Meet quarterly, or more frequently as needed, to carry out the
                  foregoing duties and responsibilities.

         (13)     Report to the board of  directors  at the next  board  meeting
                  after each Audit Committee meeting.


Membership
----------

         (1)      The Audit  Committee  shall be comprised of three  independent
                  members of the board of directors,  or such greater  number of
                  independent  members  of the board of  directors  (and/or  one
                  additional  director who is not  independent as defined by the
                  listing standards of the American Stock Exchange, and is not a
                  current  employee  or  an  immediate  family  member  of  such
                  employee,   provided  that  the  board  of  directors,   under
                  exceptional   and  limited   circumstances,   determines  that
                  membership on the committee by such  individual is required by
                  the best interests of the  corporation  and its  shareholders,
                  and the board  discloses,  in the next annual proxy  statement
                  subsequent   to  such   determination,   the   nature  of  the
                  relationship  and the reasons for that  determination)  as the
                  board of directors shall from time to time so specify.

         (2)      Each  Member of the Audit  Committee  shall be able,  or shall
                  become  able  within  a   reasonable   period  of  time  after
                  appointment  to the Audit  Committee,  to read and  understand
                  financial   statements,   including  balance  sheets,   income
                  statements, and cash flow statements.

         (3)      At least one  member of the Audit  Committee  shall  have past
                  employment  experience  in  finance or  accounting,  requisite
                  professional   certification  in  accounting,   or  any  other
                  comparable  experience  or  background  which  results  in the
                  individual's  financial  sophistication,  including  being  or
                  having been a chief executive officer, chief financial officer
                  or   other   senior   officer   with    financial    oversight
                  responsibilities.





                                      A-2



                                                                      Appendix B

                         2001 EMPLOYEE STOCK OPTION PLAN
                                       OF
                          BENTLEY PHARMACEUTICALS, INC.

         1.  PURPOSES  OF THE PLAN.  This  stock  option  plan (the  "Plan")  is
intended to provide an incentive to employees  (including directors and officers
who are employees) of Bentley Pharmaceuticals, Inc., a Delaware corporation (the
"Company"),  or any of its  Subsidiaries  (as such term is defined in  Paragraph
19), and to offer an  additional  inducement  in obtaining  the services of such
individuals.  The Plan  provides  for the  grant of  "incentive  stock  options"
("ISOs") within the meaning of Section 422 of the Internal Revenue Code of 1986,
as amended (the "Code"),  and nonqualified stock options which do not qualify as
ISOs  ("NQSOs").  The Company makes no  representation  or warranty,  express or
implied,  as to the  qualification  of any option as an "incentive stock option"
under the Code.

         2. STOCK  SUBJECT TO THE PLAN.  Subject to the  provisions of Paragraph
12, the  aggregate  number of shares of the Company's  Common  Stock,  par value
$0.02 per share  ("Common  Stock"),  for which  options may be granted under the
Plan shall not exceed  1,000,000  (one  million)  shares.  Such shares of Common
Stock may, in the  discretion  of the Board of  Directors  of the  Company  (the
"Board of  Directors"),  consist  either in whole or in part of  authorized  but
unissued  shares of Common  Stock or shares of Common Stock held in the treasury
of the Company.  Subject to the provisions of Paragraph 13, any shares of Common
Stock  subject to an option,  which for any reason  expires,  is  canceled or is
terminated  unexercised or which ceases for any reason to be  exercisable  shall
again become  available for the granting of options under the Plan.  The Company
shall at all times during the term of the Plan reserve and keep  available  such
number  of  shares  of  Common  Stock  as  will be  sufficient  to  satisfy  the
requirements of the Plan.

         3.  ADMINISTRATION  OF THE PLAN. The Plan will be  administered  by the
Board of Directors,  or by a committee  (the  "Committee")  consisting of two or
more directors appointed by the Board of Directors. Those administering the Plan
shall  be  referred  to  herein  as the  "Administrators."  Notwithstanding  the
foregoing,  if the  Company is or  becomes a  corporation  issuing  any class of
common  equity  securities  required to be  registered  under  Section 12 of the
Securities  Exchange Act of 1934, as amended (the "Exchange Act"), to the extent
necessary  to preserve  any  deduction  under  Section  162(m) of the Code or to
comply with Rule 16b-3 promulgated under the Exchange Act, or any successor rule
("Rule 16b-3"),  any Committee appointed by the Board of Directors to administer
the Plan shall be  comprised  of two or more  directors  each of whom shall be a
"non-employee  director,"  within the  meaning of Rule  16b-3,  and an  "outside
director," within the meaning of Treasury Regulation Section 1.162-27(e)(3), and
the delegation of powers to the Committee  shall be consistent  with  applicable
laws and regulations  (including,  without limitation,  applicable state law and
Rule  16b-3).  Unless  otherwise  provided  in the  By-Laws of the  Company,  by
resolution  of the Board of  Directors  or  applicable  law, a  majority  of the
members of the Committee shall  constitute a quorum,  and the acts of a majority
of the members present at any meeting at which a quorum is present, and any acts
approved in writing by all members  without a meeting,  shall be the acts of the
Committee.

         Subject to the express provisions of the Plan, the Administrators shall
have the authority, in their sole discretion, to determine the persons who shall
be granted options; the times when they shall receive options; whether an option
granted to an  employee  shall be an ISO or a NQSO;  the type  (i.e.,  voting or
non-voting)  and number of shares of Common  Stock to be subject to each

                                      B-1



option; the term of each option; the date each option shall become  exercisable;
whether an option shall be exercisable in whole or in  installments,  and, if in
installments,  the  number  of  shares of  Common  Stock to be  subject  to each
installment;  whether  the  installments  shall be  cumulative;  the  date  each
installment shall become  exercisable and the term of each installment;  whether
to accelerate the date of exercise of any option or installment;  whether shares
of Common  Stock may be issued upon the  exercise  of an option as partly  paid,
and,  if so, the dates when  future  installments  of the  exercise  price shall
become due and the  amounts of such  installments;  the  exercise  price of each
option;  the form of payment of the exercise  price;  the fair market value of a
share of Common Stock; whether and under what conditions to restrict the sale or
other disposition of the shares of Common Stock acquired upon the exercise of an
option  and,  if so,  whether  and  under  what  conditions  to  waive  any such
restriction; whether and under what conditions to subject the exercise of all or
any  portion  of an  option  to  the  fulfillment  of  certain  restrictions  or
contingencies  as  specified  in the  contract  referred to in Paragraph 11 (the
"Contract"), including without limitation restrictions or contingencies relating
to (a) entering into a covenant not to compete with the Company,  its Parent (if
any) (as  such  term is  defined  in  Paragraph  19) and any  Subsidiaries,  (b)
financial  objectives for the Company,  any of its Subsidiaries,  a division,  a
product line or other category and/or (c) the period of continued  employment of
the  optionee  with the  Company or any of its  Subsidiaries,  and to  determine
whether such  restrictions or contingencies  have been met; the amount,  if any,
necessary to satisfy the obligation of the Company,  any of its  Subsidiaries or
any  Parent to  withhold  taxes or other  amounts;  whether  an  optionee  has a
Disability  (as such term is defined in Paragraph  19);  with the consent of the
optionee,  to cancel or modify an option,  provided,  however, that the modified
provision is permitted to be included in an option granted under the Plan on the
date of the  modification;  provided,  further,  however,  that in the case of a
modification  (within the meaning of Section 424(h) of the Code) of an ISO, such
option  as  modified  would  be  permitted  to be  granted  on the  date of such
modification  under the terms of the Plan; to construe the respective  Contracts
and the Plan; to prescribe,  amend and rescind rules and regulations relating to
the Plan; to approve any  provision of the Plan or any option  granted under the
Plan or any amendment to either which, under Rule 16b-3 or Section 162(m) of the
Code,  requires  the  approval  of  the  Board  of  Directors,  a  committee  of
non-employee directors or the stockholders,  in order to be exempt under Section
16(b) of the Exchange Act (unless otherwise  specifically provided herein) or to
preserve any deduction  under Section  162(m) of the Code; and to make all other
determinations   necessary  or  advisable  for   administering   the  Plan.  Any
controversy  or claim arising out of or relating to the Plan, any option granted
under  the  Plan  or  any  Contract  shall  be  determined  unilaterally  by the
Administrators   in  their   sole   discretion.   The   determinations   of  the
Administrators  on matters  referred to in this  Paragraph 3 shall be conclusive
and binding on all parties.  No Administrator or former  Administrator  shall be
liable for any action or  determination  made in good faith with  respect to the
Plan or any option granted hereunder.

         4. ELIGIBILITY.  The Administrators  may from time to time,  consistent
with the  purposes  of the Plan,  grant  options  to such  employees  (including
officers  and  directors  who  are  employees)  of  the  Company  or  any of its
Subsidiaries, as the Administrators may determine in their sole discretion. Such
options  granted  shall  cover  such  number of  shares  of Common  Stock as the
Administrators may determine in their sole discretion;  provided,  however, that
if on the date of grant of an option,  any class of common  stock of the Company
(including  without  limitation  the Common  Stock) is required to be registered
under  Section 12 of the Exchange Act, the maximum  number of shares  subject to
options that may be granted to any employee  during any calendar  year under the
Plan shall be 250,000  shares (the "Section 162  Maximum");  provided,  further,
however,  that the aggregate market value  (determined at the time the option is
granted) of the shares of Common  Stock for which any  eligible  employee may be
granted ISOs under the Plan or any other plan of the Company,  or of a Parent or
a Subsidiary of the Company,  which are  exercisable  for the first time by such
optionee  during any calendar year shall not exceed  $100,000.  The $100,000 ISO
limitation  amount  shall be applied by taking ISOs into account in the order in
which they were granted.  Any option (or portion  thereof)  granted in excess of
such ISO  limitation  amount  shall be  treated  as a NQSO to the extent of such
excess.

                                      B-2



         5.  EXERCISE  PRICE.  The exercise  price of the shares of Common Stock
under  each  option  shall be  determined  by the  Administrators  in their sole
discretion;  provided,  however,  that the  exercise  price of an ISO, or of any
option intended to satisfy the performance-based  compensation  exemption to the
deduction  limitation  under Section 162(m) of the Code,  shall not be less than
the fair market value of the Common Stock  subject to such option on the date of
grant; and provided,  further,  however, that if, at the time an ISO is granted,
the optionee owns (or is deemed to own under  Section  424(d) of the Code) stock
possessing  more than 10% of the total  combined  voting power of all classes of
stock of the Company,  of any of its  Subsidiaries or of a Parent,  the exercise
price of such ISO shall not be less  than 110% of the fair  market  value of the
Common Stock subject to such ISO on the date of grant.

         The fair  market  value of a share of Common  Stock on any day shall be
(a) if the  principal  market  for the  Common  Stock is a  national  securities
exchange,  the average of the highest and lowest  sales  prices per share of the
Common Stock on such day as reported by such exchange or on a consolidated  tape
reflecting  transactions on such exchange,  (b) if the principal  market for the
Common  Stock is not a national  securities  exchange  and the  Common  Stock is
quoted on the Nasdaq  Stock  Market  ("Nasdaq"),  and (i) if actual  sales price
information  is available  with respect to the Common Stock,  the average of the
highest  and lowest  sales  prices per share of the Common  Stock on such day on
Nasdaq, or (ii) if such information is not available, the average of the highest
bid and the lowest  asked  prices per share for the Common  Stock on such day on
Nasdaq,  or (c) if the  principal  market for the Common Stock is not a national
securities exchange and the Common Stock is not quoted on Nasdaq, the average of
the highest bid and lowest  asked  prices per share for the Common Stock on such
day as  reported on the OTC  Bulletin  Board  Service or by  National  Quotation
Bureau, Incorporated or a comparable service; provided, however, that if clauses
(a), (b) and (c) of this Paragraph 5 are all inapplicable  because the Company's
Common Stock is not publicly traded, or if no trades have been made or no quotes
are  available  for such day,  the fair market  value of a share of Common Stock
shall be  determined by the  Administrators  by any method  consistent  with any
applicable  regulations  adopted by the  Treasury  Department  relating to stock
options.

         6. TERM.  Each  option  granted  pursuant to the Plan shall be for such
term as is established by the  Administrators,  in their sole discretion,  at or
before the time such option is granted; provided, however, that the term of each
option granted pursuant to the Plan shall be for a period not exceeding 10 years
from the date of grant thereof,  and provided  further,  that if, at the time an
ISO is granted,  the optionee owns (or is deemed to own under Section  424(d) of
the Code) stock  possessing  more than 10% of the total combined voting power of
all classes of stock of the Company,  of any of its Subsidiaries or of a Parent,
the term of the ISO shall be for a period not exceeding five years from the date
of grant.  Options  shall be  subject  to  earlier  termination  as  hereinafter
provided.

         7. EXERCISE. An option (or any installment thereof), to the extent then
exercisable,  shall be exercised by giving  written notice to the Company at its
principal office stating which option is being exercised,  specifying the number
of  shares of  Common  Stock as to which  such  option  is being  exercised  and
accompanied by payment in full of the aggregate  exercise price therefor (or the
amount due on exercise if the applicable Contract permits installment  payments)
(a) in cash  and/or  by  certified  check,  (b)  with the  authorization  of the
Administrators,  with  previously  acquired  shares  of Common  Stock  having an
aggregate fair market value  (determined in accordance with Paragraph 5), on the
date of exercise,  equal to the  aggregate  exercise  price of all options being
exercised, or (c) some combination thereof;  provided,  however, that in no case
may shares be  tendered  if such  tender  would  require  the Company to incur a
charge against its earnings for financial accounting purposes. The Company shall
not be required to issue any shares of Common Stock  pursuant to the exercise of
any option until all required payments with respect thereto,  including payments
for any required withholding amounts, have been made.

                                      B-3



         The Administrators may, in their sole discretion, permit payment of the
exercise  price of an option by delivery by the optionee of a properly  executed
notice,  together with a copy of the optionee's  irrevocable  instructions  to a
broker  acceptable to the  Administrators to deliver promptly to the Company the
amount  of sale or loan  proceeds  sufficient  to pay such  exercise  price.  In
connection  therewith,  the Company may enter into  agreements  for  coordinated
procedures with one or more brokerage firms.

         An optionee shall not have the rights of a stockholder  with respect to
such shares of Common Stock to be received  upon the exercise of an option until
the date of issuance of a stock  certificate to the optionee for such shares or,
in the case of  uncertificated  shares,  until  the date an entry is made on the
books of the  Company's  transfer  agent  representing  such  shares;  provided,
however, that until such stock certificate is issued or until such book entry is
made, any optionee using  previously  acquired shares of Common Stock in payment
of an option  exercise  price shall continue to have the rights of a stockholder
with respect to such previously acquired shares.

         In no case may a fraction of a share of Common  Stock be  purchased  or
issued under the Plan.

         8.  TERMINATION OF  RELATIONSHIP.  Except as may otherwise be expressly
provided in the applicable Contract, any optionee whose employment  relationship
with the Company, its Parent and any of its Subsidiaries, has terminated for any
reason  other than the death or  Disability  of the  optionee  may  exercise any
option granted to the optionee as an employee,  to the extent exercisable on the
date of such  termination,  at any time within  three  months  after the date of
termination,  but not thereafter and in no event after the date the option would
otherwise  have  expired;  provided,  however,  that  if  such  relationship  is
terminated either (a) for Cause (as defined in Paragraph 19), or (b) without the
consent of the  Company,  such option  shall  terminate  immediately;  provided,
further,  that if the Company  terminates  the  employee's  employment  within a
three-year  period after a change in control of the  Corporation  (as defined in
Paragraph 19), the employee during the three-month period after termination (but
not after the date on which the option would otherwise  expire) may exercise all
or any part of the remaining  unexercised portion of the option  notwithstanding
that the option had not yet become  exercisable  with  respect to all or part of
such shares at the date of termination.

         For the  purposes  of the Plan,  an  employment  relationship  shall be
deemed to exist between an individual  and a corporation  if, at the time of the
determination,  the individual was an employee of such  corporation for purposes
of Section  422(a) of the Code. As a result,  an  individual on military  leave,
sick leave or other bona fide leave of absence  shall  continue to be considered
an  employee  for  purposes  of the Plan  during such leave if the period of the
leave does not exceed 90 days, or, if longer, so long as the individual's  right
to  re-employment  with the  Company,  any of its  Subsidiaries  or a Parent  is
guaranteed  either by statute or by contract.  If the period of leave exceeds 90
days and the individual's right to re-employment is not guaranteed by statute or
by contract,  the employment  relationship shall be deemed to have terminated on
the 91st day of such leave.

         Nothing  in the Plan or in any  option  granted  under  the Plan  shall
confer on any person any right to  continue  in the employ of the  Company,  its
Parent or any of its  Subsidiaries or interfere in any way with any right of the
Company, its Parent or any of its Subsidiaries to terminate such relationship at
any time for any reason whatsoever without liability to the Company,  its Parent
or any of its Subsidiaries.

         9.  DEATH,  DISABILITY  OR  RETIREMENT  OF AN  OPTIONEE.  Except as may
otherwise be expressly provided in the applicable Contract,  if an optionee dies
(a) while he is employed by the Company,  its Parent or any of its Subsidiaries,
(b) within three  months  after the  termination  of the  optionee's  employment
relationship  with the  Company,  its Parent and its  Subsidiaries  (unless such
termination  was for Cause or without the consent of the  Company) or (c) within
one year following the termination of

                                      B-4



such  employment   relationship  by  reason  of  the  optionee's  Disability  or
Retirement (as defined in Paragraph 19), the options  granted to the optionee as
an employee of the Company or any of its Subsidiaries,  may be exercised, to the
extent  exercisable on the date of the optionee's death, by the optionee's Legal
Representative (as such term is defined in Paragraph 19), at any time within one
year after death,  but not  thereafter and in no event after the date the option
would otherwise have expired.  Except as may otherwise be expressly  provided in
the applicable  Contract,  any optionee whose employment  relationship  with the
Company,  its  Parent  and its  Subsidiaries  has  terminated  by  reason of the
optionee's  Disability  or Retirement  may exercise such options,  to the extent
exercisable upon the effective date of such termination,  at any time within one
year after  such date,  but not  thereafter  and in no event  after the date the
option would otherwise have expired.

         10.  COMPLIANCE WITH SECURITIES LAWS. It is a condition to the exercise
of any option that either (a) a Registration  Statement under the Securities Act
of 1933, as amended (the "Securities Act"), with respect to the shares of Common
Stock to be issued upon such exercise shall be effective and current at the time
of exercise, or (b) there is an exemption from registration under the Securities
Act for the issuance of the shares of Common Stock upon such  exercise.  Nothing
herein shall be construed as requiring the Company to register shares subject to
any  option  under  the  Securities  Act or to keep any  Registration  Statement
effective or current.

         The  Administrators  may  require,  in  their  sole  discretion,  as  a
condition to the grant or exercise of an option,  that the optionee  execute and
deliver to the Company the optionee's  representations and warranties,  in form,
substance and scope satisfactory to the Administrators, which the Administrators
determine  is  necessary  or  convenient  to  facilitate  the  perfection  of an
exemption from the registration  requirements of the Securities Act,  applicable
state securities laws or other legal requirements, including without limitation,
that (a) the shares of Common Stock to be issued upon exercise of the option are
being acquired by the optionee for the  optionee's  own account,  for investment
only and not with a view to the  resale  or  distribution  thereof,  and (b) any
subsequent  resale or  distribution  of shares of Common Stock by such  optionee
will be made only pursuant to (i) a Registration  Statement under the Securities
Act which is  effective  and current  with respect to the shares of Common Stock
being sold, or (ii) a specific  exemption from the registration  requirements of
the Securities Act, but in claiming such exemption,  the optionee,  prior to any
offer of sale or sale of such shares of Common Stock,  shall provide the Company
with a favorable  written  opinion of counsel  satisfactory  to the Company,  in
form,  substance and scope satisfactory to the Company,  as to the applicability
of such exemption to the proposed sale or distribution.

         In addition, if at any time the Administrators shall determine that the
listing or qualification of the shares of Common Stock subject to such option on
any securities exchange, Nasdaq or under any applicable law, or that the consent
or approval of any  governmental  agency or  regulatory  body,  is  necessary or
desirable as a condition to, or in connection with, the granting of an option or
the  issuance  of shares of Common  Stock  thereunder,  such  option  may not be
granted  or  exercised  in  whole or in part,  as the case may be,  unless  such
listing, qualification, consent or approval shall have been effected or obtained
free of any conditions not acceptable to the Administrators.

         11.  STOCK  OPTION  CONTRACTS.  Each option  shall be  evidenced  by an
appropriate  Contract  which  shall  be duly  executed  by the  Company  and the
optionee.  Such Contract shall contain such terms, provisions and conditions not
inconsistent  herewith as may be determined by the  Administrators in their sole
discretion. The terms of each option and Contract need not be identical.

         12. ADJUSTMENTS UPON CHANGES IN COMMON STOCK. Notwithstanding any other
provision  of the Plan,  in the event of any  change in the  outstanding  Common
Stock by  reason  of a stock  dividend,  recapitalization,  merger  in which the
Company  is  the  surviving  corporation,  spin-off,  split-up,

                                      B-5


combination  or exchange of shares or the like which  results in a change in the
number or kind of shares of Common Stock which are outstanding immediately prior
to such event,  the aggregate number and kind of shares subject to the Plan, the
aggregate number and kind of shares subject to each  outstanding  option and the
exercise price thereof, and the maximum number of shares subject to options that
may be granted to any  employee in any  calendar  year,  shall be  appropriately
adjusted by the Board of Directors,  whose determination shall be conclusive and
binding on all  parties.  Such  adjustment  may provide for the  elimination  of
fractional  shares that might  otherwise be subject to options  without  payment
therefor. Notwithstanding the foregoing, no adjustment shall be made pursuant to
this Paragraph 12 if such  adjustment (a) would cause the Plan to fail to comply
with  Section  422 of the  Code or  with  Rule  16b-3  of the  Exchange  Act (if
applicable to such option),  or (b) would be considered as the adoption of a new
plan requiring stockholder approval.

         In the event of a proposed  dissolution  or liquidation of the Company,
or in the event of a proposed sale of all or substantially  all of the assets of
the Company, or the merger of the Company with or into another corporation,  the
Board of Directors of the Company shall, as to outstanding  options,  either (a)
make appropriate provision for the protection of any such outstanding options by
the substitution on an equitable basis of appropriate stock of the Company or of
the merged,  consolidated  or otherwise  reorganized  corporation  which will be
issuable in respect to one share of Common Stock of the Company;  provided  that
the excess of the  aggregate  fair  market  value of the  shares  subject to the
options  immediately  after such substitution over the purchase price thereof is
not more than the  excess  of the  aggregate  fair  market  value of the  shares
subject to such options  immediately  before such substitution over the purchase
price  thereof,  or (b) upon  written  notice to an  optionee,  provide that all
unexercised  options must be exercised  within a specified number of days of the
date of such notice or they will be  terminated.  In any such case, the Board of
Directors  may,  in  its  discretion,  advance  the  lapse  of  any  waiting  or
installment periods and exercise dates.

         13. AMENDMENTS AND TERMINATION OF THE PLAN. The Plan was adopted by the
Board of Directors on March 30,  2001.  No option may be granted  under the Plan
after March 30, 2011. The Board of Directors,  without  further  approval of the
Company's stockholders,  may at any time suspend or terminate the Plan, in whole
or in  part,  or  amend  it from  time to time in such  respects  as it may deem
advisable,  including without  limitation,  in order that ISOs granted hereunder
meet the requirements for "incentive stock options" under the Code, or to comply
with the provisions of Rule 16b-3 or Section 162(m) of the Code or any change in
applicable laws or regulations,  ruling or  interpretation  of any  governmental
agency  or  regulatory  body;  provided,  however,  that no  amendment  shall be
effective, without the requisite prior or subsequent stockholder approval, which
would (a) except as contemplated in Paragraph 12, increase the maximum number of
shares of Common Stock for which options may be granted under the Plan or change
the Section 162 Maximum, (b) change the eligibility requirements for individuals
entitled  to  receive  options  hereunder,  or (c) make  any  change  for  which
applicable  law  or  any   governmental   agency  or  regulatory  body  requires
stockholder approval. No termination,  suspension or amendment of the Plan shall
adversely  affect the rights of an optionee  under any option  granted under the
Plan  without  such  optionee's  consent.  The  power of the  Administrators  to
construe  and  administer  any  option  granted  under  the  Plan  prior  to the
termination or suspension of the Plan shall  continue after such  termination or
during such suspension.

         14.  NON-TRANSFERABILITY.  No option  granted  under the Plan  shall be
transferable  other than by will or the laws of descent  and  distribution,  and
options  may be  exercised,  during the  lifetime of the  optionee,  only by the
optionee or the optionee's Legal Representatives.  Except to the extent provided
above,  options  may not be  assigned,  transferred,  pledged,  hypothecated  or
disposed of in any way (whether by operation of law or otherwise)  and shall not
be subject to execution,  attachment or similar

                                      B-6




process, and any such attempted assignment,  transfer, pledge,  hypothecation or
disposition shall be null and void ab initio and of no force or effect.

         15.  WITHHOLDING  TAXES. The Company,  or its Subsidiary or Parent,  as
applicable,  may withhold (a) cash or (b) with the consent of the Administrators
(in the  Contract  or  otherwise),  shares  of Common  Stock to be  issued  upon
exercise of an option or a combination  of cash and shares,  having an aggregate
fair market  value  (determined  in  accordance  with  Paragraph 5) equal to the
amount which the Administrators determine is necessary to satisfy the obligation
of the Company,  a  Subsidiary  or Parent to withhold  Federal,  state and local
income taxes or other amounts incurred by reason of the grant, vesting, exercise
or  disposition  of an option or the  disposition  of the  underlying  shares of
Common Stock. Alternatively,  the Company may require the optionee to pay to the
Company such amount, in cash, promptly upon demand.

         16. LEGENDS;  PAYMENT OF EXPENSES.  The Company may endorse such legend
or legends upon the certificates for shares of Common Stock issued upon exercise
of an option under the Plan and may issue such "stop  transfer"  instructions to
its  transfer  agent in respect  of such  shares as it  determines,  in its sole
discretion,  to be necessary or appropriate to (a) prevent a violation of, or to
perfect an exemption from, the registration  requirements of the Securities Act,
applicable state securities laws or other legal requirements,  (b) implement the
provisions  of the Plan or any  agreement  between the Company and the  optionee
with  respect to such  shares of Common  Stock,  or (c)  permit  the  Company to
determine  the  occurrence  of a  "disqualifying  disposition,"  as described in
Section 421(b) of the Code, of the shares of Common Stock  transferred  upon the
exercise of an ISO granted under the Plan.

         The Company  shall pay all issuance  taxes with respect to the issuance
of shares of Common Stock upon the exercise of an option granted under the Plan,
as well as all fees and expenses incurred by the Company in connection with such
issuance.

         17. USE OF PROCEEDS. The cash proceeds to be received upon the exercise
of an option  under the Plan shall be added to the general  funds of the Company
and used for such corporate purposes as the Board of Directors may determine, in
its sole discretion.

         18.  SUBSTITUTIONS  AND  ASSUMPTIONS OF OPTIONS OF CERTAIN  CONSTITUENT
CORPORATIONS.  Anything in this Plan to the contrary notwithstanding,  the Board
of Directors may, without further approval by the  stockholders,  substitute new
options for prior options of a Constituent  Corporation (as such term is defined
in Paragraph 19) or assume the prior options of such Constituent Corporation.

                                      B-7


19.      Definitions.
         -----------

                  (1)  "Cause",   in  connection  with  the  termination  of  an
         optionee,  shall mean (i)  "cause," as such term (or any similar  term,
         such as "with cause") is defined in any employment or other  applicable
         agreement for services  between the Company and such optionee,  or (ii)
         in the absence of such an agreement, "cause" as such term is defined in
         the  Contract  executed by the Company  and such  optionee  pursuant to
         Paragraph  11, or (iii) in the  absence of both of the  foregoing,  (A)
         indictment  of such  optionee for any illegal  conduct,  (B) failure of
         such optionee to adequately  perform any of the  optionee's  duties and
         responsibilities  in any  capacity  held with the  Company,  any of its
         Subsidiaries  or any  Parent  (other  than any such  failure  resulting
         solely from such  optionee's  physical or mental  incapacity),  (C) the
         commission  of any act or failure to act by such optionee that involves
         moral turpitude,  dishonesty,  theft,  destruction of property,  fraud,
         embezzlement  or  unethical  business  conduct,  or that  is  otherwise
         injurious to the Company,  any of its Subsidiaries or any Parent or any
         other affiliate of the Company (or its or their respective  employees),
         whether financially or otherwise, (D) any violation by such optionee of
         any Company rule or policy,  or (E) any  violation by such  optionee of
         the  requirements  of such  Contract,  any other  contract or agreement
         between the  Company and such  optionee or this Plan (as in effect from
         time to time);  in each case,  with respect to subsections  (A) through
         (E), as determined by the Board of Directors.

                  (2)  "change  in  control  of  the  Company"  shall  mean  any
         acquisition  by any  corporation,  person or entity,  of the beneficial
         ownership,  directly or indirectly,  of voting stock of the Corporation
         resulting in such  corporation,  person or entity  owning,  directly or
         indirectly,  50% or more of such voting  stock.  For the purpose of the
         foregoing   definition  of  change  in  control  of  the  Company,  any
         corporation,  person  or  other  entity  shall  be  deemed  to  be  the
         beneficial owner of any shares of voting stock of the Company (i) which
         it has the right to acquire, hold or vote pursuant to any agreement, or
         upon exercise of conversion rights,  warrants or options, or otherwise,
         or (ii) which are beneficially owned, directly or indirectly (including
         shares deemed owned through  application  of clause (i) above),  by any
         other  corporation,   person  or  entity  (A)  with  which  it  or  its
         "affiliate"  or  "associate"  (as those terms are defined in Rule 12b-2
         promulgated  under the Exchange Act) has any agreement,  arrangement or
         understanding  for  the  purpose  of  acquiring,   holding,  voting  or
         disposing  of  voting  stock  of  the  Company,  or  (B)  which  is its
         "affiliate" or "associate".  In computing the aforesaid percentage, the
         outstanding  shares of voting stock of the Company shall include shares
         deemed owned through  application of clauses (i) and (ii) but shall not
         include  any  other  shares  which  may  be  issuable  pursuant  to any
         agreement,  or upon exercise of conversion rights,  warrants or options
         or otherwise.

                  (3) "Constituent Corporation" shall mean any corporation which
         engages with the Company, its Parent or any Subsidiary in a transaction
         to which  Section  424(a) of the Code  applies  (or would  apply if the
         option  assumed  or  substituted  were an ISO),  or any  Parent  or any
         Subsidiary of such corporation.

                  (4)  "Disability"  shall mean a permanent and total disability
         within the meaning of Section 22(e)(3) of the Code.

                  (5)   "Legal   Representative"   shall   mean  the   executor,
         administrator  or other  person who at the time is  entitled  by law to
         exercise  the  rights of a  deceased  or  incapacitated  optionee  with
         respect to an option granted under the Plan.

                  (6)  "Parent"  shall  mean a "parent  corporation"  within the
         meaning of Section 424(e) of the Code.

                                      B-8




                  (7)  "Retirement"  shall mean  retirement  no earlier than the
         normal retirement age pursuant to any pension or retirement plan of the
         Company or a Subsidiary or Parent.

                  (8) "Subsidiary" shall mean a "subsidiary  corporation" within
         the meaning of Section 424(f) of the Code.

         20. GOVERNING LAW. The Plan, such options as may be granted  hereunder,
the  Contracts  and all related  matters  shall be governed by, and construed in
accordance  with, the laws of the State of Delaware,  without regard to conflict
or choice of law provisions.

         Neither the Plan nor any Contract  shall be  construed  or  interpreted
with any  presumption  against the Company by reason of the Company  causing the
Plan or Contract to be drafted.

         Whenever  from the context it appears  appropriate,  any term stated in
either the  singular or plural shall  include the  singular and plural,  and any
term  stated in the  masculine,  feminine  or neuter  gender  shall  include the
masculine, feminine and neuter.

         21. PARTIAL INVALIDITY. The invalidity,  illegality or unenforceability
of any  provision  in the Plan,  any  option or  Contract  shall not  affect the
validity,  legality or enforceability of any other provision, all of which shall
be valid,  legal and  enforceable to the fullest extent  permitted by applicable
law.

         22.  STOCKHOLDER  APPROVAL.  The Plan shall be subject to approval by a
majority of the votes present in person and by proxy  entitled to vote hereon at
a duly held meeting of the Company's  stockholders at which a quorum is present.
No options granted hereunder may be exercised prior to such approval,  provided,
however, that the date of grant of any option shall be determined as if the Plan
had not been subject to such approval.  Notwithstanding  the  foregoing,  if the
Plan is not approved by a vote of the  stockholders  of the Company on or before
December 31, 2001, the Plan and any options granted hereunder shall terminate.

                                      B-9



                                                                      Appendix C

                        2001 DIRECTORS' STOCK OPTION PLAN
                                       OF
                          BENTLEY PHARMACEUTICALS, INC.

         1.  PURPOSES  OF THE PLAN.  This  stock  option  plan (the  "Plan")  is
intended to provide an incentive  to members and former  members of the Board of
Directors  who are not  employees of Bentley  Pharmaceuticals,  Inc., a Delaware
corporation (the "Company"), or any of its Subsidiaries (as such term is defined
in  Paragraph  19),  and to offer an  additional  inducement  in  obtaining  the
services of such  individuals.  The Plan provides for the grant of  nonqualified
stock options ("NQSOs") which do not qualify as "incentive stock options" within
the meaning of Section 422 of the Internal Revenue Code of 1986, as amended (the
"Code").

         2. STOCK  SUBJECT TO THE PLAN.  Subject to the  provisions of Paragraph
12, the  aggregate  number of shares of the Company's  Common  Stock,  par value
$0.02 per share  ("Common  Stock"),  for which  options may be granted under the
Plan shall not exceed  500,000 (five hundred  thousand)  shares.  Such shares of
Common  Stock may, in the  discretion  of the Board of  Directors of the Company
(the "Board of Directors"), consist either in whole or in part of authorized but
unissued  shares of Common  Stock or shares of Common Stock held in the treasury
of the Company.  Subject to the provisions of Paragraph 13, any shares of Common
Stock  subject to an option,  which for any reason  expires,  is  canceled or is
terminated  unexercised or which ceases for any reason to be  exercisable  shall
again become  available for the granting of options under the Plan.  The Company
shall at all times during the term of the Plan reserve and keep  available  such
number  of  shares  of  Common  Stock  as  will be  sufficient  to  satisfy  the
requirements of the Plan.

         3.  ADMINISTRATION  OF THE PLAN. The Plan will be  administered  by the
Board of Directors or by a committee (the "Committee") consisting of two or more
directors  appointed by the Board of  Directors.  Those  administering  the Plan
shall  be  referred  to  herein  as the  "Administrators."  Notwithstanding  the
foregoing,  if the  Company is or  becomes a  corporation  issuing  any class of
common  equity  securities  required to be  registered  under  Section 12 of the
Securities  Exchange Act of 1934, as amended (the "Exchange Act"), to the extent
necessary to comply with Rule 16b-3  promulgated  under the Exchange Act, or any
successor rule ("Rule 16b-3"), any Committee appointed by the Board of Directors
to administer  the Plan shall be comprised of two or more directors each of whom
shall be a  "non-employee  director,"  within the meaning of Rule 16b-3,  and an
"outside   director,"  within  the  meaning  of  Treasury   Regulation   Section
1.162-27(e)(3),  and  the  delegation  of  powers  to  the  Committee  shall  be
consistent with applicable laws and regulations (including,  without limitation,
applicable state law and Rule 16b-3).  Unless otherwise  provided in the By-Laws
of the Company,  by resolution  of the Board of Directors or  applicable  law, a
majority of the members of the Committee shall constitute a quorum, and the acts
of a  majority  of the  members  present  at any  meeting  at which a quorum  is
present,  and any acts  approved  in writing by all  members  without a meeting,
shall be the acts of the Committee.

         Subject to the express provisions of the Plan, the Administrators shall
have the authority, in their sole discretion, to determine the persons who shall
be granted options;  the times when they shall receive options;  the type (i.e.,
voting or non-voting) and number of shares of Common Stock to be subject to each
option; the term of each option; the date each option shall become  exercisable;
whether an option shall be exercisable in whole or in  installments,  and, if in
installments,  the  number  of  shares of  Common  Stock to be  subject  to each
installment;  whether  the  installments  shall be  cumulative;  the  date  each
installment shall become  exercisable and the term of each installment;  whether
to accelerate the date of exercise of

                                      C-1



any option or installment; whether shares of Common Stock may be issued upon the
exercise  of an  option as partly  paid,  and,  if so,  the  dates  when  future
installments  of the  exercise  price  shall  become due and the amounts of such
installments;  the  exercise  price of each  option;  the form of payment of the
exercise  price;  the fair market value of a share of Common Stock;  whether and
under what conditions to restrict the sale or other disposition of the shares of
Common Stock  acquired  upon the  exercise of an option and, if so,  whether and
under what  conditions  to waive any such  restriction;  whether  and under what
conditions  to subject  the  exercise  of all or any portion of an option to the
fulfillment  of  certain  restrictions  or  contingencies  as  specified  in the
contract referred to in Paragraph 11 (the "Contract"); whether an optionee has a
Disability  (as such term is defined in Paragraph  19);  with the consent of the
optionee,  to cancel or modify an option,  provided,  however, that the modified
provision is permitted to be included in an option granted under the Plan on the
date of the modification;  to construe the respective Contracts and the Plan; to
prescribe,  amend and rescind  rules and  regulations  relating to the Plan;  to
approve any  provision of the Plan or any option  granted  under the Plan or any
amendment to either which, under Rule 16b-3,  requires the approval of the Board
of Directors,  a committee of  non-employee  directors or the  stockholders,  in
order to be exempt under  Section  16(b) of the  Exchange Act (unless  otherwise
specifically provided herein); and to make all other determinations necessary or
advisable for administering the Plan. Any controversy or claim arising out of or
relating to the Plan, any option granted under the Plan or any Contract shall be
determined  unilaterally by the  Administrators  in their sole  discretion.  The
determinations of the  Administrators on matters referred to in this Paragraph 3
shall be  conclusive  and binding on all  parties.  No  Administrator  or former
Administrator shall be liable for any action or determination made in good faith
with respect to the Plan or any option granted hereunder.

         4. ELIGIBILITY.  The Administrators  may from time to time,  consistent
with the purposes of the Plan,  grant options to directors who are not employees
of the Company or any of its Subsidiaries,  as the  Administrators may determine
in their sole discretion,  or approve a formula pursuant to which such directors
are automatically  granted options from time to time. Such options granted shall
cover such number of shares of Common Stock as the  Administrators may determine
in their sole discretion.

         5.  EXERCISE  PRICE.  The exercise  price of the shares of Common Stock
under  each  option  shall be  determined  by the  Administrators  in their sole
discretion,  provided,  however,  that the exercise price shall not be less than
the fair market value of the Common Stock  subject to such option on the date of
grant.

         The fair  market  value of a share of Common  Stock on any day shall be
(a) if the  principal  market  for the  Common  Stock is a  national  securities
exchange,  the average of the highest and lowest  sales  prices per share of the
Common Stock on such day as reported by such exchange or on a consolidated  tape
reflecting  transactions on such exchange,  (b) if the principal  market for the
Common  Stock is not a national  securities  exchange  and the  Common  Stock is
quoted on the Nasdaq  Stock  Market  ("Nasdaq"),  and (i) if actual  sales price
information  is available  with respect to the Common Stock,  the average of the
highest  and lowest  sales  prices per share of the Common  Stock on such day on
Nasdaq, or (ii) if such information is not available, the average of the highest
bid and the lowest  asked  prices per share for the Common  Stock on such day on
Nasdaq,  or (c) if the  principal  market for the Common Stock is not a national
securities exchange and the Common Stock is not quoted on Nasdaq, the average of
the highest bid and lowest  asked  prices per share for the Common Stock on such
day as  reported on the OTC  Bulletin  Board  Service or by  National  Quotation
Bureau, Incorporated or a comparable service; provided, however, that if clauses
(a), (b) and (c) of this Paragraph 5 are all inapplicable  because the Company's
Common Stock is not publicly traded, or if no trades have been made or no quotes
are  available  for such

                                      C-2




day, the fair market value of a share of Common Stock shall be determined by the
Administrators by any method consistent with any applicable  regulations adopted
by the Treasury Department relating to stock options.

         6. TERM.  Each  option  granted  pursuant to the Plan shall be for such
term as is established by the  Administrators,  in their sole discretion,  at or
before the time such option is granted; provided, however, that the term of each
option granted pursuant to the Plan shall be for a period not exceeding 10 years
from the date of grant thereof.  Options shall be subject to earlier termination
as hereinafter provided.

         7. EXERCISE. An option (or any installment thereof), to the extent then
exercisable,  shall be exercised by giving  written notice to the Company at its
principal office stating which option is being exercised,  specifying the number
of  shares of  Common  Stock as to which  such  option  is being  exercised  and
accompanied by payment in full of the aggregate  exercise price therefor (or the
amount due on exercise if the applicable Contract permits installment  payments)
(a) in cash  and/or  by  certified  check,  (b)  with the  authorization  of the
Administrators,  with  previously  acquired  shares  of Common  Stock  having an
aggregate fair market value  (determined in accordance with Paragraph 5), on the
date of exercise,  equal to the  aggregate  exercise  price of all options being
exercised, or (c) some combination thereof;  provided,  however, that in no case
may shares be  tendered  if such  tender  would  require  the Company to incur a
charge against its earnings for financial accounting purposes. The Company shall
not be required to issue any shares of Common Stock  pursuant to the exercise of
any option until all required payments with respect thereto,  including payments
for any required withholding amounts, have been made.

         The Administrators may, in their sole discretion, permit payment of the
exercise  price of an option by delivery by the optionee of a properly  executed
notice,  together with a copy of the optionee's  irrevocable  instructions  to a
broker  acceptable to the  Administrators to deliver promptly to the Company the
amount  of sale or loan  proceeds  sufficient  to pay such  exercise  price.  In
connection  therewith,  the Company may enter into  agreements  for  coordinated
procedures with one or more brokerage firms.

         An optionee shall not have the rights of a stockholder  with respect to
such shares of Common Stock to be received  upon the exercise of an option until
the date of issuance of a stock  certificate to the optionee for such shares or,
in the case of  uncertificated  shares,  until  the date an entry is made on the
books of the  Company's  transfer  agent  representing  such  shares;  provided,
however, that until such stock certificate is issued or until such book entry is
made, any optionee using  previously  acquired shares of Common Stock in payment
of an option  exercise  price shall continue to have the rights of a stockholder
with respect to such previously acquired shares.

         In no case may a fraction of a share of Common  Stock be  purchased  or
issued under the Plan.

         8.  TERMINATION OF  RELATIONSHIP.  Except as may otherwise be expressly
provided in the applicable  Contract or in the Plan, any optionee,  other than a
Director  Emeritus (as such term is define in Paragraph 19) whose  membership on
the Board of Directors of the Company has  terminated  for any reason other than
the death or Disability of the optionee or the  engagement of the optionee as an
employee of the Company, may exercise any option granted to the optionee, to the
extent  exercisable  on the date of such  termination,  at any time within three
months after the date of  termination,  but not thereafter and in no event after
the date the option would  otherwise have expired;  provided,  however,  that if
such  directorship  is terminated  for Cause (as defined in Paragraph  19), such
option shall  terminate

                                      C-3



immediately;  provided, further, that if the optionee ceases to be a director as
the result of his  removal or failure to be  nominated  for  re-election  to the
Board, or his Director Emeritus status is terminated, within three years after a
change in control of the Company (as defined in Paragraph  19),  such  optionee,
during the three month  period  after  cessation  of service or  termination  of
status, may exercise all or any part of the remaining unexercised portion of the
option  notwithstanding  that the  option had not yet  become  exercisable  with
respect  to all or part of such  shares at the date of  cessation  of service or
termination of status.  Except  hereinabove  provided,  in the event an optionee
shall cease to serve on the Board but shall have been  designated  as a Director
Emeritus,  his option shall  continue to be  exercisable as though such Director
Emeritus continued to serve as a director.

         Nothing  in the Plan or in any  option  granted  under  the Plan  shall
confer on any  person any right to  continue  as a  director  of the  Company or
interfere  in  any  way  with  any  right  of  the  Company  to  terminate  such
relationship  at any time for any reason  whatsoever  without  liability  to the
Company, its Parent or any of its Subsidiaries.

         9. DEATH OR  DISABILITY  OF AN  OPTIONEE.  Except as may  otherwise  be
expressly provided in the applicable Contract,  if an optionee dies (a) while he
is a member of the Board of Directors  of the  Company,  (b) within three months
after the  termination of the optionee's  directorship  with the Company (unless
such termination was for Cause) or (c) within one year following the termination
of such directorship by reason of the optionee's Disability, the options granted
to the optionee may be exercised,  to the extent  exercisable on the date of the
optionee's  death,  by the  optionee's  Legal  Representative  (as such  term is
defined in  Paragraph  19),  at any time  within one year after  death,  but not
thereafter  and in no event  after  the date the  option  would  otherwise  have
expired.  Except  as may  otherwise  be  expressly  provided  in the  applicable
Contract,  any optionee  whose  directorship  with the Company has terminated by
reason of the  optionee's  Disability  may exercise such options,  to the extent
exercisable upon the effective date of such termination,  at any time within one
year after  such date,  but not  thereafter  and in no event  after the date the
option would otherwise have expired.

         10.  COMPLIANCE WITH SECURITIES LAWS. It is a condition to the exercise
of any option that either (a) a Registration  Statement under the Securities Act
of 1933, as amended (the "Securities Act"), with respect to the shares of Common
Stock to be issued upon such exercise shall be effective and current at the time
of exercise, or (b) there is an exemption from registration under the Securities
Act for the issuance of the shares of Common Stock upon such  exercise.  Nothing
herein shall be construed as requiring the Company to register shares subject to
any  option  under  the  Securities  Act or to keep any  Registration  Statement
effective or current.

         The  Administrators  may  require,  in  their  sole  discretion,  as  a
condition to the grant or exercise of an option,  that the optionee  execute and
deliver to the Company the optionee's  representations and warranties,  in form,
substance and scope satisfactory to the Administrators, which the Administrators
determine  is  necessary  or  convenient  to  facilitate  the  perfection  of an
exemption from the registration  requirements of the Securities Act,  applicable
state securities laws or other legal requirements, including without limitation,
that (a) the shares of Common Stock to be issued upon exercise of the option are
being acquired by the optionee for the  optionee's  own account,  for investment
only and not with a view to the  resale  or  distribution  thereof,  and (b) any
subsequent  resale or  distribution  of shares of Common Stock by such  optionee
will be made only pursuant to (i) a Registration  Statement under the Securities
Act which is  effective  and current  with respect to the shares of Common Stock
being sold, or (ii) a specific  exemption from the registration  requirements of
the Securities Act, but in claiming such exemption,  the optionee,

                                      C-4




prior to any offer of sale or sale of such shares of Common Stock, shall provide
the Company  with a favorable  written  opinion of counsel  satisfactory  to the
Company,  in form,  substance and scope  satisfactory to the Company,  as to the
applicability of such exemption to the proposed sale or distribution.

         In addition, if at any time the Administrators shall determine that the
listing or qualification of the shares of Common Stock subject to such option on
any securities exchange, Nasdaq or under any applicable law, or that the consent
or approval of any  governmental  agency or  regulatory  body,  is  necessary or
desirable as a condition to, or in connection with, the granting of an option or
the  issuance  of shares of Common  Stock  thereunder,  such  option  may not be
granted  or  exercised  in  whole or in part,  as the case may be,  unless  such
listing, qualification, consent or approval shall have been effected or obtained
free of any conditions not acceptable to the Administrators.

         11.  STOCK  OPTION  CONTRACTS.  Each option  shall be  evidenced  by an
appropriate  Contract  which  shall  be duly  executed  by the  Company  and the
optionee.  Such Contract shall contain such terms, provisions and conditions not
inconsistent  herewith as may be determined by the  Administrators in their sole
discretion. The terms of each option and Contract need not be identical.

         12. ADJUSTMENTS UPON CHANGES IN COMMON STOCK. Notwithstanding any other
provision  of the Plan,  in the event of any  change in the  outstanding  Common
Stock by  reason  of a stock  dividend,  recapitalization,  merger  in which the
Company  is  the  surviving  corporation,  spin-off,  split-up,  combination  or
exchange  of shares or the like which  results in a change in the number or kind
of shares of Common Stock which are outstanding immediately prior to such event,
the aggregate  number and kind of shares  subject to the Plan, and the aggregate
number and kind of shares  subject to each  outstanding  option and the exercise
price thereof, shall be appropriately adjusted by the Board of Directors,  whose
determination  shall be conclusive and binding on all parties.  Such  adjustment
may provide for the  elimination  of fractional  shares that might  otherwise be
subject to options without payment therefor.  Notwithstanding the foregoing,  no
adjustment  shall be made pursuant to this  Paragraph 12 if such  adjustment (a)
would cause the Plan to fail to comply with Rule 16b-3 of the  Exchange  Act (if
applicable to such option),  or (b) would be considered as the adoption of a new
plan requiring stockholder approval.

         In the event of a proposed  dissolution  or liquidation of the Company,
or in the event of a proposed sale of all or substantially  all of the assets of
the Company, or the merger of the Company with or into another corporation,  the
Board of Directors of the Company shall, as to outstanding  options,  either (a)
make appropriate provision for the protection of any such outstanding options by
the substitution on an equitable basis of appropriate stock of the Company or of
the merged,  consolidated  or otherwise  reorganized  corporation  which will be
issuable in respect to one share of Common Stock of the Company;  provided  that
the excess of the  aggregate  fair  market  value of the  shares  subject to the
options  immediately  after such substitution over the purchase price thereof is
not more than the  excess  of the  aggregate  fair  market  value of the  shares
subject to such options  immediately  before such substitution over the purchase
price  thereof,  or (b) upon  written  notice to an  optionee,  provide that all
unexercised  options must be exercised  within a specified number of days of the
date of such notice or they will be  terminated.  In any such case, the Board of
Directors  may,  in  its  discretion,  advance  the  lapse  of  any  waiting  or
installment periods and exercise dates.

         13. AMENDMENTS AND TERMINATION OF THE PLAN. The Plan was adopted by the
Board of Directors on March 30,  2001.  No option may be granted  under the Plan
after March 30, 2011. The Board of Directors,  without  further  approval of the
Company's stockholders,  may at any time suspend or

                                      C-5



terminate  the Plan,  in whole or in part, or amend it from time to time in such
respects as it may deem advisable,  including without limitation, to comply with
the  provisions of Rule 16b-3 or any change in applicable  laws or  regulations,
ruling  or  interpretation  of  any  governmental  agency  or  regulatory  body;
provided,  however, that no amendment shall be effective,  without the requisite
prior or subsequent stockholder approval, which would (a) change the eligibility
requirements for individuals entitled to receive options hereunder,  or (b) make
any change for which  applicable  law or any  governmental  agency or regulatory
body requires stockholder approval.  No termination,  suspension or amendment of
the Plan  shall  adversely  affect the  rights of an  optionee  under any option
granted  under  the Plan  without  such  optionee's  consent.  The  power of the
Administrators  to construe and  administer  any option  granted  under the Plan
prior to the  termination  or suspension of the Plan shall  continue  after such
termination or during such suspension.

         14.  NON-TRANSFERABILITY.  No option  granted  under the Plan  shall be
transferable  other than by will or the laws of descent  and  distribution,  and
options  may be  exercised,  during the  lifetime of the  optionee,  only by the
optionee or the optionee's Legal Representatives.  Except to the extent provided
above,  options  may not be  assigned,  transferred,  pledged,  hypothecated  or
disposed of in any way (whether by operation of law or otherwise)  and shall not
be subject to execution,  attachment or similar process,  and any such attempted
assignment,  transfer,  pledge,  hypothecation or disposition  shall be null and
void ab initio and of no force or effect.

         15.  WITHHOLDING  TAXES.  The Company may withhold (a) cash or (b) with
the consent of the  Administrators  (in the  Contract or  otherwise),  shares of
Common Stock to be issued upon  exercise of an option or a  combination  of cash
and shares, having an aggregate fair market value (determined in accordance with
Paragraph 5) equal to the amount which the Administrators determine is necessary
to satisfy the  obligation of the Company to withhold  Federal,  state and local
income taxes or other amounts incurred by reason of the grant, vesting, exercise
or  disposition  of an option or the  disposition  of the  underlying  shares of
Common Stock. Alternatively,  the Company may require the optionee to pay to the
Company such amount, in cash, promptly upon demand.

         16. LEGENDS;  PAYMENT OF EXPENSES.  The Company may endorse such legend
or legends upon the certificates for shares of Common Stock issued upon exercise
of an option under the Plan and may issue such "stop  transfer"  instructions to
its  transfer  agent in respect  of such  shares as it  determines,  in its sole
discretion,  to be necessary or appropriate to (a) prevent a violation of, or to
perfect an exemption from, the registration  requirements of the Securities Act,
applicable state securities laws or other legal  requirements,  or (b) implement
the provisions of the Plan or any agreement between the Company and the optionee
with respect to such shares of Common Stock.

         The Company  shall pay all issuance  taxes with respect to the issuance
of shares of Common Stock upon the exercise of an option granted under the Plan,
as well as all fees and expenses incurred by the Company in connection with such
issuance.

         17. USE OF PROCEEDS. The cash proceeds to be received upon the exercise
of an option  under the Plan shall be added to the general  funds of the Company
and used for such corporate purposes as the Board of Directors may determine, in
its sole discretion.

         18.  SUBSTITUTIONS  AND  ASSUMPTIONS OF OPTIONS OF CERTAIN  CONSTITUENT
CORPORATIONS.  Anything in this Plan to the contrary notwithstanding,  the Board
of Directors may, without further

                                      C-6




approval by the  stockholders,  substitute  new  options for prior  options of a
Constituent  Corporation (as such term is defined in Paragraph 19) or assume the
prior options of such Constituent Corporation.

19.      Definitions.
         -----------

                  (1)  "Cause",   in  connection  with  the  termination  of  an
         optionee,  shall mean (i)  "cause," as such term (or any similar  term,
         such as "with cause") is defined in any agreement for services  between
         the  Company  and  such  optionee,  or (ii) in the  absence  of such an
         agreement,  "cause" as such term is defined in the Contract executed by
         the Company and such optionee pursuant to Paragraph 11, or (iii) in the
         absence of both of the  foregoing,  (A) indictment of such optionee for
         any illegal conduct, (B) failure of such optionee to adequately perform
         any of the optionee's duties and  responsibilities in any capacity held
         with the Company, any of its Subsidiaries or any Parent (other than any
         such failure  resulting solely from such optionee's  physical or mental
         incapacity),  (C) the  commission  of any act or failure to act by such
         optionee that involves moral turpitude,  dishonesty, theft, destruction
         of property, fraud, embezzlement or unethical business conduct, or that
         is otherwise  injurious to the Company,  any of its Subsidiaries or any
         Parent  or  any  other  affiliate  of the  Company  (or  its  or  their
         respective  employees),  whether  financially  or  otherwise,  (D)  any
         violation by such  optionee of any Company  rule or policy,  or (E) any
         violation by such optionee of the  requirements  of such Contract,  any
         other  contract or agreement  between the Company and such  optionee or
         this Plan (as in effect from time to time);  in each case, with respect
         to  subsections  (A)  through  (E),  as  determined  by  the  Board  of
         Directors.

                  (2)  "change  in  control  of  the  Company"  shall  mean  any
         acquisition  by any  corporation,  person or entity,  of the beneficial
         ownership,  directly or indirectly,  of voting stock of the Corporation
         resulting in such  corporation,  person or entity  owning,  directly or
         indirectly,  50% or more of such voting  stock.  For the purpose of the
         foregoing   definition  of  change  in  control  of  the  Company,  any
         corporation,  person  or  other  entity  shall  be  deemed  to  be  the
         beneficial owner of any shares of voting stock of the Company (i) which
         it has the right to acquire, hold or vote pursuant to any agreement, or
         upon exercise of conversion rights,  warrants or options, or otherwise,
         or (ii) which are beneficially owned, directly or indirectly (including
         shares deemed owned through  application  of clause (i) above),  by any
         other  corporation,   person  or  entity  (A)  with  which  it  or  its
         "affiliate"  or  "associate"  (as those terms are defined in Rule 12b-2
         promulgated  under the Exchange Act) has any agreement,  arrangement or
         understanding  for  the  purpose  of  acquiring,   holding,  voting  or
         disposing  of  voting  stock  of  the  Company,  or  (B)  which  is its
         "affiliate" or "associate".  In computing the aforesaid percentage, the
         outstanding  shares of voting stock of the Company shall include shares
         deemed owned through  application of clauses (i) and (ii) but shall not
         include  any  other  shares  which  may  be  issuable  pursuant  to any
         agreement,  or upon exercise of conversion rights,  warrants or options
         or otherwise.

                  (3) "Constituent Corporation" shall mean any corporation which
         engages with the Company, its Parent or any Subsidiary in a transaction
         to which  Section  424(a)  of the Code  applies,  or any  Parent or any
         Subsidiary of such corporation.

                  (4) "Director  Emeritus"  shall mean an honorary title granted
         by majority vote of the members of the Board then serving.

                  (5)  "Disability"  shall mean a permanent and total disability
         within the meaning of Section 22(e)(3) of the Code.

                                      C-7




                  (6)   "Legal   Representative"   shall   mean  the   executor,
         administrator  or other  person who at the time is  entitled  by law to
         exercise  the  rights of a  deceased  or  incapacitated  optionee  with
         respect to an option granted under the Plan.

                  (7)  "Parent"  shall  mean a "parent  corporation"  within the
         meaning of Section 424(e) of the Code.

                  (8) "Subsidiary" shall mean a "subsidiary  corporation" within
         the meaning of Section 424(f) of the Code.

         20. GOVERNING LAW. The Plan, such options as may be granted  hereunder,
the  Contracts  and all related  matters  shall be governed by, and construed in
accordance  with, the laws of the State of Delaware,  without regard to conflict
or choice of law provisions.

         Neither the Plan nor any Contract  shall be  construed  or  interpreted
with any  presumption  against the Company by reason of the Company  causing the
Plan  or  Contract  to  be  drafted.   Whenever  from  the  context  it  appears
appropriate,  any term stated in either the singular or plural shall include the
singular and plural,  and any term stated in the  masculine,  feminine or neuter
gender shall include the masculine, feminine and neuter.

         21. PARTIAL INVALIDITY. The invalidity,  illegality or unenforceability
of any  provision  in the Plan,  any  option or  Contract  shall not  affect the
validity,  legality or enforceability of any other provision, all of which shall
be valid,  legal and  enforceable to the fullest extent  permitted by applicable
law.

         22.  STOCKHOLDER  APPROVAL.  The Plan shall be subject to approval by a
majority of the votes present in person and by proxy  entitled to vote hereon at
a duly held meeting of the Company's  stockholders at which a quorum is present.
No options granted hereunder may be exercised prior to such approval,  provided,
however, that the date of grant of any option shall be determined as if the Plan
had not been subject to such approval.  Notwithstanding  the  foregoing,  if the
Plan is not approved by a vote of the  stockholders  of the Company on or before
December 31, 2001, the Plan and any options granted hereunder shall terminate.





                          BENTLEY PHARMACEUTICALS, INC.
                  ANNUAL MEETING OF STOCKHOLDERS - MAY 9, 2001
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

         The  undersigned  holder of Common  Stock of  Bentley  Pharmaceuticals,
Inc., a Delaware  corporation (the "Company"),  hereby appoints James R. Murphy,
Michael D.  Price and Jordan A.  Horvath  and each of them,  as proxies  for the
undersigned,  each with full power of  substitution,  for and in the name of the
undersigned to act for the undersigned and to vote, as designated  below, all of
the shares of stock of the Company that the  undersigned  is entitled to vote at
the 2001 Annual Meeting of Stockholders of the Company, to be held on Wednesday,
May 9,  2001,  at 11:00  a.m.,  local  time,  at the Hyatt  Harborside  Hotel at
Boston's Logan  International  Airport located at 101 Harborside Drive,  Boston,
Massachusetts 02128 and at any adjournments or postponements thereof.

                  (CONTINUED AND TO BE SIGNED ON REVERSE SIDE)


                                      -1-




1.  The  election  of Class II  Directors  until  the  2004  Annual  Meeting  of
Stockholders,  or until  the  election  and  qualification  of their  respective
successors:

|_|    FOR ALL NOMINEES       |_|    WITHHOLD AUTHORITY to vote for all nominees

(INSTRUCTION: To withhold authority for any        Nominees:  Charles L. Bolling
individual nominee, strike a line through the                 Robert J. Gyurik
nominee's name on the list at right.)                         William A. Packer


2.     The proposal to approve the Company's 2001 Employee Stock Option Plan.

       |_|   FOR             |_|    AGAINST             |_|   ABSTAIN


3.     The proposal to approve the Company's 2001 Directors' Stock Option Plan.

       |_|   FOR             |_|    AGAINST             |_|   ABSTAIN

4. Upon such other  matters as may properly  come before the Annual  Meeting and
any adjournments or postponements thereof. In their discretion,  the proxies are
authorized  to vote upon such other  business  as may  properly  come before the
Annual Meeting and any adjournments or postponements thereof.

THIS PROXY, WHEN PROPERLY EXECUTED,  WILL BE VOTED IN THE MANNER DIRECTED HEREIN
BY THE  UNDERSIGNED  STOCKHOLDER.  IF NO DIRECTION  IS MADE,  THIS PROXY WILL BE
VOTED  "FOR" THE  ELECTION OF ALL CLASS II DIRECTOR  NOMINEES  LISTED  ABOVE AND
"FOR" PROPOSALS 2 AND 3.

The undersigned hereby acknowledges receipt of (i) the Notice of Annual Meeting,
(ii) the Proxy Statement and (iii) the Company's 2000 Annual Report.

PLEASE  MARK,  SIGN AND DATE  THIS  PROXY  CARD AND  PROMPTLY  RETURN  IT IN THE
ENVELOPE PROVIDED. NO POSTAGE NECESSARY IF MAILED IN THE UNITED STATES.


                                 _________________________________
                                 Signature

                                 _________________________________
                                 Print Full Name

                                 _________________________________
                                 Signature

                                 ________________________________
                                 Print Full Name


                                 Dated: ______________________, 2001

NOTE: Please sign exactly as your name appears hereon and mail it promptly. When
shares are held by joint  tenants,  both should sign.  When signing as attorney,
executor, administrator, trustee or guardian, please give full title as such. If
a  corporation,  please  sign  in full  corporate  name by  president  or  other
authorized  officer.  If a  partnership,  please  sign  in  partnership  name by
authorized person.


                                      -2-