FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * KAYNE RICHARD A   2. Issuer Name and Ticker or Trading Symbol Kayne Anderson MLP/Midstream Investment Co [KYN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) __X__ Other (specify below) SEE NOTES (1) AND (2) (Last) (First) (Middle) C/O KAYNE ANDERSON CAPITAL ADVISORS LP, 1800 AVENUE OF THE STARS, THIRD FLOOR 3. Date of Earliest Transaction (Month/Day/Year) 10/22/2018 (Street) LOS ANGELES, CA 90067 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price COMMON STOCK 10/22/2018   J(1)   152,445 A (1) (2) 353,958 D   COMMON STOCK 10/22/2018   J(1)   303,568 D (1) (2) 11,321 I (2) SEE NOTES (1) (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
KAYNE RICHARD A C/O KAYNE ANDERSON CAPITAL ADVISORS LP 1800 AVENUE OF THE STARS, THIRD FLOOR LOS ANGELES, CA 90067				SEE NOTES (1) AND (2)
KAYNE ANDERSON CAPITAL ADVISORS LP 1800 AVENUE OF THE STARS, THIRD FLOOR LOS ANGELES, CA 90067				SEE NOTE (2)
KA Fund Advisors LLC C/O KAYNE ANDERSON CAPITAL ADVISORS, L.P 1800 AVENUE OF THE STARS, THIRD FLOOR LOS ANGELES, CA 90067				SEE NOTE (2)

Signatures

/S/ DAVID SHLADOVSKY BY POWER OF ATTORNEY FOR RICHARD A. KAYNE		10/22/2018
**Signature of Reporting Person		Date
/S/ DAVID SHLADOVSKY BY POWER OF ATTORNEY FOR KAYNE ANDERSON CAPITAL ADVISORS, L.P.		10/22/2018
**Signature of Reporting Person		Date
/S/ DAVID SHLADOVSKY BY POWER OF ATTORNEY FOR KA FUND ADVISORS, LLC		10/22/2018
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	SHARES DISTRIBUTED BY KAYNE ANDERSON CAPITAL ADVISORS, L.P. ("KACALP") TO ITS LIMITED PARTNERS (ON A PRO RATA BASIS.). AFTER GIVING EFFECT TO THAT DISTRIBUTION, KACALP OWNED NO SHARES OF KYN.
(2)	A TOTAL OF 11,235 SHARES ARE OWNED BY KA ASSOCIATES, INC. ("KAA.") RICHARD KAYNE IS THE MAJORITY OWNER OF KAA. A TOTAL OF 86 SHARES ARE OWNED BY KA FUND ADVISORS, LLC ("KAFA.") MR. KAYNE IS THE INDIRECT MAJORITY OWNER OF KAFA. MR. KAYNE DISCLAIMS BENEFICIAL OWNERSHIP OF ALL SHARES HELD OR CONTROLLED BY KAA AND KAFA EXCEPT TO THE EXTENT OF HIS PECUNIARY INTEREST THEREIN.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.