Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Smullen Richard Michael
 2. Date of Event Requiring Statement (Month/Day/Year)
02/23/2006		 3. Issuer Name and Ticker or Trading Symbol
MEDIMMUNE INC /DE [MEDI]
(Last)
(First)
(Middle)
ONE MEDIMMUNE WAY		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Sales
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

GAITHERSBURG, MD 20878		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 367
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Options (Right to buy)   (1) 02/24/2009 Common Stock 12,000 $ 18.9063 D  
Stock Options (Right to buy)   (2) 02/17/2010 Common Stock 45,000 $ 60.4167 D  
Stock Options (Right to buy)   (3) 05/30/2010 Common Stock 15,000 $ 49.4167 D  
Stock Options (Right to buy)   (4) 02/15/2011 Common Stock 30,000 $ 38.688 D  
Stock Options (Right to buy)   (5) 02/21/2012 Common Stock 38,000 $ 41.41 D  
Stock Options (Right to buy)   (6) 02/20/2013 Common Stock 40,000 $ 29.34 D  
Stock Options (Right to buy)   (7) 03/04/2014 Common Stock 25,000 $ 23.45 D  
Stock Options (Right to buy)   (8) 02/16/2015 Common Stock 20,000 $ 24.17 D  
Stock Options (Right to buy)   (9) 02/23/2016 Common Stock 25,000 $ 36.78 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Smullen Richard Michael
ONE MEDIMMUNE WAY
GAITHERSBURG, MD 20878		       SVP, Sales  

Signatures

/s/William C. Bertrand, Jr. Attorney-in-Fact 02/27/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Exercisable in equal annual installments over a four-year period following date of grant.
(2) Exercisable in equal annual installments over a four-year period following date of grant.
(3) Exercisable in equal annual installments over a four-year period following date of grant.
(4) Exercisable in equal quarterly installments over a four-year period following date of grant.
(5) Exercisable in equal quarterly installments over a four-year period following date of grant.
(6) Exercisable in equal quarterly installments over a four-year period following date of grant.
(7) Exercisable in equal quarterly installments over a four-year period following date of grant.
(8) Exercisable in equal quarterly installments over a four-year period following date of grant.
(9) Exercisable in equal quarterly installments over a four-year period following date of grant.

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