OMB APPROVAL OMB Number: 3235-0578 Expires: April 30, 2013 Estimated average burden hours per response..... 5.6 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-Q QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY Investment Company Act file number 811-21409 Pioneer Municipal High Income Advantage Trust (Exact name of registrant as specified in charter) 60 State Street, Boston, MA 02109 (Address of principal executive offices) (ZIP code) Terrence J. Cullen, Pioneer Investment Management, Inc., 60 State Street, Boston, MA 02109 (Name and address of agent for service) Registrant's telephone number, including area code: (617) 742-7825 Date of fiscal year end: March 31 Date of reporting period: June 30, 2010 Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after close of the first and third fiscal quarters, pursuant to Rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles. A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss. 3507. ITEM 1. Schedule of Investments. Pioneer Municipal High Income Advantage Trust SCHEDULE OF INVESTMENTS 6/30/10 (unaudited) Principal Amount Value TAX-EXEMPT OBLIGATIONS - 143.9% of Net Assets Alabama - 0.7% 2,500,000Huntsville-Redstone Village Special Care Faci $ 1,896,625 Arizona - 3.4% 5,000,000Casa Grande Industrial Development Authority $ 4,987,500 1,521,000Pima County Industrial Development Authority, 1,473,803 2,640,000Pima County Industrial Development Authority, 2,466,974 1,000,000San Luis Facility Development Corp., 7.25%, 5 917,080 $ 9,845,357 California - 12.3% 3,140,000California State University Revenue, RIB, 12. $ 3,232,504 2,425,000California State Various Purpose, 5.75%, 4/1/ 2,570,621 8,575,000California State Various Purpose, RIB, 12.752 8,574,057 803,175 California Statewide Communities Development 79,113 2,680,000Golden State Tobacco Securitization Corp., 6. 3,113,838 2,500,000San Jose California Airport Revenue, 5.0%, 3/ 2,470,775 10,500,00University of California, RIB, 13.063%, 5/15/ 10,897,740 7,670,000Valley Health System Hospital Revenue, 6.875% 4,205,768 $ 35,144,416 Colorado - 1.1% 2,850,000Denver Health & Hospital Authority Healthcare $ 3,070,704 Connecticut - 2.7% 7,750,000Connecticut State Development Authority Reven $ 7,706,987 District of Columbia - 3.3% 2,700,000District of Columbia Tobacco Settlement Finan $ 2,585,331 6,825,000District of Columbia Tobacco Settlement Finan 6,737,981 $ 9,323,312 Florida - 3.7% 4,500,000Hillsborough County Industrial Development Authority Pollution Control Revenue, 5.5%, 10/1/23 $ 4,588,290 1,980,000Hillsborough County Industrial Development Au 1,928,401 1,000,000Hillsborough County Industrial Development Au 1,135,630 500,000 Miami Beach Health Facilities Authority, 5.37 432,435 2,500,000Miami-Dade County Florida Aviation Revenue, 5 2,541,450 $ 10,626,206 Georgia - 4.6% 5,210,000Atlanta Georgia Water and Wastewater Revenue, $ 5,113,615 1,000,000Clayton County Development Authority Special 1,037,850 900,000 DeKalb County Hospital Authority Revenue, 6.0 899,910 750,000 DeKalb County Hospital Authority Revenue, 6.1 744,308 1,065,000Effingham County Industrial Development Autho 1,064,925 3,360,000Fulton County Residential Care Facilities, 7. 2,531,525 1,650,000Savannah Georgia Economic Development Authori 1,652,937 $ 13,045,070 Guam - 1.8% 4,500,000Northern Mariana Islands, 6.75%, 10/1/33 $ 5,221,035 Idaho - 1.7% 2,000,000Power County Industrial Development Corp., 6. $ 2,011,700 3,000,000Power County Pollution Control Revenue, 5.625 2,999,850 $ 5,011,550 Illinois - 7.5% 3,000,000Centerpoint Intermodal Center, 7.5%, 6/15/23 $ 3,024,810 2,000,000City of Chicago Illinois, 5.5%, 12/1/30 1,464,080 1,450,000Illinois Finance Authority Revenue, 5.5%, 4/1 1,445,708 1,000,000Illinois Finance Authority Revenue, 6.0%, 11/ 778,660 2,000,000Illinois Finance Authority Revenue, 6.0%, 8/1 2,093,900 2,000,000Illinois Finance Authority Revenue, 6.0%, 8/1 2,175,520 2,500,000Illinois Finance Authority Revenue, 6.125%, 1 2,208,250 6,000,000Illinois Finance Authority Revenue, 8.25%, 5/ 5,884,740 1,500,000Illinois Health Facilities Authority Revenue, 570,600 2,525,000Southwestern Illinois Development Authority R 1,843,906 $ 21,490,174 Indiana - 5.8% 250,000 East Chicago Indiana Exempt Facilities Reven $ 240,833 10,000,00Indiana State Development Finance Authority R 10,189,800 5,000,000Jasper County Industrial Economic Development 4,540,900 1,995,000Vincennes Industrial Economic Development Rev 1,675,421 $ 16,646,954 Kentucky - 1.5% 500,000 Kentucky Economic Development Finance Authority Hospital System Revenue, 5.7%, 10/1/10 $ 500,055 4,400,000Kentucky Economic Development Finance Authority Hospital System Revenue, 5.875%, 10/1/22 3,909,400 $ 4,409,455 Louisiana - 6.2% 2,500,000Louisiana Local Government Environmental Faci $ 2,578,300 Authority Revenue, 6.75%, 11/1/32 6,000,000Louisiana Public Facilities Authority Revenue 5,317,320 750,000 Opelousas Louisiana General Hospital Authorit 759,135 9,415,000Tobacco Settlement Financing Corp., 5.875%, 5 9,190,641 $ 17,845,396 Maryland - 0.9% 460,000 Maryland Health & Higher Educational Faciliti $ 380,379 1,250,000Maryland Health & Higher Educational Faciliti 894,363 1,250,000Maryland Health & Higher Educational Faciliti 1,185,200 $ 2,459,942 Massachusetts - 7.6% 830,000 Massachusetts Development Finance Agency, 5.2 $ 737,140 5,000,000Massachusetts Development Finance Agency, 5.7 5,523,650 1,930,000Massachusetts Development Finance Agency, 7.1 1,766,008 2,195,000Massachusetts Health & Educational Facilities 1,920,054 1,000,000Massachusetts Health & Educational Facilities 1,126,140 10,760,00Massachusetts Housing Finance Agency, 5.35%, 10,541,787 $ 21,614,779 Michigan - 3.5% 1,500,000Delta County Michigan Economic Development Co $ 1,652,700 500,000 Flint Michigan Hospital Building Authority Re 505,700 3,000,000Macomb County Hospital Finance Authority Reve 3,483,570 745,000 Michigan Public Educational Facilities Author 680,252 4,130,000Michigan State Hospital Finance Authority Rev 3,622,712 3,405,000Wayne Charter Escrow, 0.0%, 12/1/15 $ 9,944,934 Missouri - 0.9% 1,500,000St. Louis Industrial Development Authority Re $ 480,540 6,640,000St. Louis Industrial Development Authority Re 2,124,070 $ 2,604,610 Montana - 0.5% 2,445,000Hardin Increment Industrial Infrastructure De $ 1,385,435 1,000,000Two Rivers Authority, Inc., Project Revenue, 174,950 $ 1,560,385 Nevada - 2.1% 1,500,000Henderson Nevada Health Care Facilities Reven $ 1,539,645 1,600,000Nevada State Department of Business & Industr 16,000 1,000,000Nevada State Department of Business & Industr 10,000 1,320,000Nevada State Department of Business & Industr 13,200 5,000,000Reno Nevada Hospital Revenue, 5.25%, 6/1/41 4,579,800 $ 6,158,645 New Hampshire - 0.4% 1,125,000New Hampshire Health & Educational Facilities $ 1,067,557 New Jersey - 11.9% 2,500,000Burlington County New Jersey Bridge Commissio $ 2,158,775 13,000,00New Jersey Economic Development Authority Rev 11,951,290 3,500,000New Jersey State Turnpike Authority, RIB, 13. 4,882,430 10,375,00New Jersey Transportation Trust Fund Authorit 4,284,875 1,000,000Tobacco Settlement Financing Corp., 6.25%, 6/ 1,155,470 3,250,000Tobacco Settlement Financing Corp., 6.75%, 6/ 3,802,045 5,000,000Tobacco Settlement Financing Corp., 7.0%, 6/1 5,883,650 $ 34,118,535 New York - 7.9% 1,800,000Dutchess County Industrial Development Agency $ 1,796,148 3,000,000Nassau County New York Industrial Development 2,949,330 5,000,000New York City Industrial Development Agency, 3,705,400 3,950,000New York City Industrial Development Agency, 3,944,154 2,000,000New York State Dormitory Authority Revenue, 6 1,992,000 5,000,000New York State Environmental Facilities Corp. 5,125,500 3,000,000Ulster County New York Industrial Development 2,718,900 500,000 Ulster County New York Industrial Development 409,965 $ 22,641,397 North Carolina - 2.1% 6,000,000Charlotte North Carolina Special Facilities R $ 6,003,720 Ohio - 1.7% 2,375,000Belmont County Health System Revenue, 5.7%, 1 $ 1,726,554 1,000,000Belmont County Health System Revenue, 5.8%, 1 727,460 3,000,000Cleveland Airport Special Revenue, 5.375%, 9/ 2,487,600 $ 4,941,614 Oklahoma - 2.8% 1,500,000Jackson County Memorial Hospital Authority Re $ 1,501,050 2,220,000Tulsa Municipal Airport Trust Revenue, 6.25%, 2,026,616 1,500,000Tulsa Municipal Airport Trust Revenue, 7.35%, 1,499,850 3,000,000Tulsa Municipal Airport Trust Revenue, 7.75%, 3,015,210 $ 8,042,726 Oregon - 1.1% 3,000,000Oregon State Facilities Authority Revenue, 5. $ 3,021,030 Pennsylvania - 8.8% 3,000,000Allegheny County Hospital Development Authori $ 3,159,690 500,000 Allegheny County Hospital Development Authori 526,615 3,600,000Columbia County Hospital Authority Revenue, 5 3,222,036 830,000 Hazleton Health Services Authority Hospital R 829,992 1,405,000Montgomery County Higher Education & Health Authority Hospital Revenue, 6.6%, 7/1/10 1,405,197 1,430,000Pennsylvania Economic Development Financing Authority Revenue, 5.125%, 6/1/18 1,284,941 2,330,000Pennsylvania Economic Development Financing A 2,292,137 5,000,000Pennsylvania Economic Development Financing A 4,315,100 5,000,000Philadelphia Hospitals & Higher Education Fac 4,079,050 2,005,000Scranton-Lackawanna Health & Welfare Authorit 1,979,476 2,245,000Scranton-Lackawanna Health & Welfare Authorit 2,189,953 $ 25,284,187 Rhode Island - 3.2% 1,385,000Central Falls Rhode Island Detention Faciliti $ 1,186,405 8,285,000Tobacco Settlement Financing Corp., 6.25%, 6/ 7,847,801 $ 9,034,206 South Carolina - 6.2% 1,500,000Connector 2000 Association, Inc., Toll Road R $ 303,750 7,140,000South Carolina Jobs Economic Development Auth 8,244,986 860,000 South Carolina Jobs Economic Development Auth 998,778 3,000,000South Carolina Jobs Economic Development Auth 3,112,800 4,400,000Tobacco Settlement Revenue Management, 6.375% 5,231,204 $ 17,891,518 Tennessee - 3.8% 1,000,000Johnson City Health & Educational Facilities $ 1,133,710 7,000,000Knox County Health Educational & Housing Facilities Board Hospital Revenue, 6.5%, 4/15/31 7,450,660 2,400,000Sullivan County Health Educational and Housing Facilities Board Hospital Revenue, 5.25%, 9/1/36 2,193,120 $ 10,777,490 Texas - 16.4% 2,827,399Gulf Coast Industrial Development Authority, $ 278,499 10,000,00Houston Texas Airport System Special Faciliti 9,729,200 845,000 IAH Public Facility Corp., Project Revenue Bo 779,791 1,000,000IAH Public Facility Corp., Project Revenue Bo 831,290 1,350,000IAH Public Facility Corp., Project Revenue Bo 1,083,524 2,750,000Lower Colorado River Authority, 5.0%, 5/15/31 2,777,775 845,000 Lubbock Health Facilities Development Corp., 813,346 2,000,000Lubbock Health Facilities Development Corp., 1,846,560 7,750,000Matagorda County Navigation District Number 1 7,677,150 9,750,000North Texas Tollway Authority Revenue, 5.75%, 10,246,372 1,711,000Panhandle Regional Housing Finance Corp. Multifamily Housing Revenue, 6.6%, 7/20/31 1,814,533 1,000,000Richardson Hospital Authority Revenue, 6.0%, 948,500 1,000,000Tarrant County Cultural Education Facilities 994,090 1,500,000Tarrant County Cultural Education Facilities 1,497,210 1,000,000Texas Midwest Public Facility Corp. Revenue, 1,034,700 4,700,000Tomball Hospital Authority, 6.0%, 7/1/25 4,568,870 $ 46,921,410 Utah - 0.5% 1,600,000Spanish Fork Charter School Revenue, 5.7%, 11 $ 1,295,760 Virginia - 0.8% 2,000,000Washington County Industrial Development Auth $ 2,274,700 Washington - 3.1% 1,155,000Tobacco Settlement Authority Revenue, 6.5%, 6 $ 1,180,202 2,000,000Washington State Health Care Facilities Autho 2,038,500 2,000,000Washington State Health Care Facilities Autho 2,045,900 5,000,000Washington State Housing Finance Commission Nonprofit Revenue Bonds, 5.625%, 1/1/27 3,740,550 $ 9,005,152 Wisconsin - 1.4% 2,900,000Aztalan Wisconsin Exempt Facilities Revenue, $ 391,500 1,000,000Wisconsin State Health & Educational Faciliti 1,006,360 1,000,000Wisconsin State Health & Educational Faciliti 972,190 1,500,000Wisconsin State Health & Educational Faciliti 1,622,025 $ 3,992,075 TOTAL TAX-EXEMPT OBLIGATIONS (Cost $405,289,753) $ 411,939,613 MUNICIPAL COLLATERALIZED DEBT OBLIGATION - 3.4% of Net Assets 13,000,00Non-Profit Preferred Funding Trust I, Series $ 9,638,070 TOTAL MUNICIPAL COLLATERALIZED DEBT OBLIGATION (Cost $13,000,000) $ 9,638,070 Shares COMMON STOCK - 0.5% of Net Assets 109,889 Delta Airlines, Inc. $ 1,291,196 TOTAL COMMON STOCK (Cost $3,210,349) $ 1,291,196 TAX-EXEMPT MONEY MARKET MUTUAL FUND - 1.0% of Net Assets 3,000,0BlackRock Liquidity Funds MuniFund Portfolio $ 3,000,000 TOTAL TAX-EXEMPT MONEY MARKET MUTUAL FUND (Cost $3,000,000) $ 3,000,000 TOTAL INVESTMENTS IN SECURITIES - 148.8% (Cost $424,500,102) (i)(j) $ 425,868,879 OTHER ASSETS AND LIABILITIES 3.6% $ 10,327,030 PREFERRED SHARES AT REDEMPTION VALUE, INCLUDING DIVIDENDS PAYABLE - (52.4)% $ (150,005,046) NET ASSETS APPLICABLE TO COMMON SHAREOWNERS - $ 286,190,863 (144A) Security is exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold normally to qualified institutional buyers in a transaction exempt from registration. At June 30, 2010, the value of these securities amounted to $35,761,246, or 12.5% of total net assets applicable to common shareowners. RIB Residual Interest Bonds. NR Security not rated by S&P or Moody's. + Prerefunded bonds have been collateralized by U.S. Treasury or U.S. Government Agency securities which are held in escrow to pay interest and principal on the tax exempt issue and to retire the bonds in full at the earliest refunding date. (a) The interest rate is subject to change periodically and inversely based upon prevailing market rates. The rate shown is the coupon rate at June 30, 2010. (b) Security is in default and is non-income producing. (c) The interest rate is subject to change periodically. The interest rate shown is the coupon rate at June 30, 2010. (d) Non-income producing. (e) Security is valued using fair value methods (other than prices supplied by independent pricing services). (f) Debt obligation initially issued at one coupon rate which converts to a higher coupon rate at a specific date. The rate shown is the coupon rate at June 30, 2010. (g) Indicates a security that has been deemed illiquid. The aggregate cost of illiquid securities is $16,341,938. The aggregate value is $10,042,770, or 3.5% of the total net assets applied to common shareowners. (h) Escrow to maturity. (i) The concentration of investments by type of obligation/market sector is as follows: Insured AGM 8.2 % AMBAC 1.9 MBIA 1.0 Q-SBLF 0.2 Revenue Bonds: Health Revenue 35.5 Airport Revenue 11.4 Tobacco Revenue 11.1 Other Revenue 8.0 Pollution Control Revenue 6.6 Development Revenue 5.1 Housing Revenue 2.9 Facilities Revenue 2.5 Transportation Revenue 2.5 Water Revenue 1.2 Power Revenue 1.1 Education Revenue 0.8 Utilities Revenue* 0.0 100.0% Amount is less than 0.1% (j) At June 30, 2010, the net unrealized gain on investments based on cost for federal income tax purposes of $419,754,512 was as follows: Aggregate gross unrealized gain for all investments in which there is an excess of value over tax cos $ 39,904,297 Aggregate gross unrealized loss for all investments in which there is an excess of tax cost over valu (33,789,930) Net unrealized gain $ 6,114,367 For financial reporting purposes net unrealized gain on investments was $1,368,777 and cost of investments aggregated $424,500,102. Purchases and sales of securities (excluding temporary cash investments) for the period ended June 30, 2010 aggregated $10,694,210 and $8,042,380, respectively. Various inputs are used in determining the value of the Fund's investments. These inputs are summarized in the three broad levels listed below. Highest priority is given to Level 1 inputs and lowest priority is given to Level 3. Level 1 - quoted prices in active markets for identical securities Level 2 - other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.) Level 3 - significant unobservable inputs (including the Fund's own assumptions in determining fair value of investments) The following is a summary of the inputs used as of June 30, 2010, in valuing the Fund's assets: Level 1 Level 2 Level 3 Total Tax exempt obligations $0 $411,939,613 $0 $411,939,613 Municipal collateralized 0 9,368,070 0 9,368,070 Common Stock 1,291,196 0 0 1,291,196 Tax exempt money market 3,000,000 0 0 3,000,000 Total $4,291,196 $421,307,683 $0 $425,598,879 Following is a reconciliation of assets valued using significant unobservable inputs (Level 3): Tax-Exempt Obligation Michigan Balance as of 3/31/10 $0 Realized gain (loss) 0 Change in unrealized gain (loss) 0 Net purchases (sales) 0 Transfers in and out of level 3 Balance as of 6/30/10 $0 ITEM 2. CONTROLS AND PROCEDURES. (a) Disclose the conclusions of the registrant's principal executive and principal financial officers, or persons performing similar functions, regarding the effectiveness of the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Act (17 CFR 270.30a-3(c))) as of a date within 90 days of the filing date of the report that includes the disclosure required by this paragraph, based on the evaluation of these controls and procedures required by Rule 30a-3(b) under the Act (17 CFR 270.30a-3(b))) and Rule 13a-15(b) or 15d-15(b) under the Exchange Act (17 CFR 240.13a-15(b) or 240.15d-15(b)). The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report. (b) Disclose any change in the registrant's internal controls over financial reporting (as defined in Rule 30a-3(d) under the Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting. There were no significant changes in the registrant's internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 3. EXHIBITS. (a) A separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the Act (17 CFR 270.30a-2(a)). Filed herewith. SIGNATURES [See General Instruction F] Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. (Registrant) Pioneer Municipal High Income Advantage Trust By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr, President Date August 27, 2010 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr., President Date August 27, 2010 By (Signature and Title)* /s/ Mark Bradley Mark Bradley, Treasurer Date August 27, 2010 * Print the name and title of each signing officer under his or her signature.