Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Marshall William Stuart
 2. Date of Event Requiring Statement (Month/Day/Year)
02/13/2017		 3. Issuer Name and Ticker or Trading Symbol
MIRAGEN THERAPEUTICS, INC. [MGEN]
(Last)
(First)
(Middle)
C/O MIRAGEN THERAPEUTICS, INC., 6200 LOOKOUT ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President & CEO
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BOULDER, CO 80301		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 148,578 (1) (2)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) (1)   (3) 07/30/2018 Common Stock 115,818 $ 0.57 D  
Stock Option (right to buy) (1)   (4) 06/14/2022 Common Stock 230,968 $ 1.22 D  
Stock Option (right to buy) (1)   (5) 02/21/2026 Common Stock 156,791 $ 1.05 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Marshall William Stuart
C/O MIRAGEN THERAPEUTICS, INC.
6200 LOOKOUT ROAD
BOULDER, CO 80301		   X     President & CEO  

Signatures

/s/ Brent D. Fassett, as Attorney-in-Fact for William Stuart Marshall 02/13/2017
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares of common stock of the corporation then known as Miragen Therapeutics, Inc. ("Old Miragen") were converted into shares of the Issuer pursuant to that certain Agreement and Plan of Merger and Reorganization, dated as of October 31, 2016, by and among the Issuer, Signal Merger Sub, Inc. and Old Miragen (the "Merger Agreement"). Pursuant to the terms of the Merger Agreement, each share of common stock was converted into 0.7031 shares of the Issuer's common stock.
(2) Reporting Person held 211,319 shares of common stock of Old Miragen prior to the conversion pursuant to the Merger Agreement including: 150,000 shares of common stock of Old Miragen; and shares of common stock of Old Miragen issued upon the conversion of 37,586 shares of Series A convertible preferred stock of Old Miragen, 6,470 share of Series B convertible preferred stock of Old Miragen and 17,263 shares of Series C convertible preferred stock of Old Miragen. Immediately prior to the effective time of the merger, each share of Old Miragen preferred stock converted into one share of Old Miragen's common stock.
(3) On July 31, 2008, Reporting Person was granted an option to purchase 164,726 shares of the common stock of Old Miragen under Old Miragen's Equity Incentive Plan (the "Plan") at an exercise price of $0.40 per share. Pursuant to the Merger Agreement, this option was converted into an option to purchase 115,818 shares of the Issuer's common stock at a per share exercise price of $0.57. The option is fully vested and exercisable. The option expires ten years after the date of grant.
(4) On June 15, 2012, Reporting Person was granted an option to purchase 328,500 shares of the common stock of Old Miragen under the Plan at an exercise price of $0.86 per share. Pursuant to the Merger Agreement, this option was converted into an option to purchase 230,968 shares of the Issuer's common stock at a per share exercise price of $1.22. The option is fully vested and exercisable. The option expires ten years after the date of grant.
(5) On February 22, 2016, Reporting Person was granted an option to purchase 223,000 shares of common stock of Old Miragen under the Plan at an exercise price of $0.74 per share. Pursuant to the Merger Agreement, this option was converted into an option to purchase 156,791 shares of the Issuer's common stock at a per share exercise price of $1.05. The shares subject to the option vest in 48 equal monthly installments beginning on March 22, 2016, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The shares underlying the option are subject to accelerated vesting upon the occurrence of specified events including a change of control of the Issuer and the Reporting Person's termination. The option expires ten years after the date of grant.
 
Remarks:
Exhibit List: Exhibit 24 - Power of Attorney

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