Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
AMMON CAROL A
   2. Issuer Name and Ticker or Trading Symbol
ENDO PHARMACEUTICALS HOLDINGS INC [ENDP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
100 PAINTERS DRIVE		 3. Date of Earliest Transaction (Month/Day/Year)
10/12/2005
(Street)

CHADDS FORD, PA 19317		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $.01 per share 10/12/2005   M   946,419 A $ 3 946,419 D  
Common Stock, par value $.01 per share 10/12/2005   M   403,000 A $ 3.42 1,349,419 D  
Common Stock, par value $.01 per share 10/12/2005   M   2,423,892 A $ 2.42 3,773,311 D  
Common Stock, par value $.01 per share 10/12/2005   M   344,263 A $ 3 4,117,574 D  
Common Stock, par value $.01 per share 10/12/2005   M   156,903 A $ 3 4,274,477 D  
Common Stock, par value $.01 per share 10/12/2005   M   110,351 A $ 2.42 4,384,828 D  
Common Stock, par value $.01 per share 10/12/2005   M   848,099 A $ 3 5,232,927 D  
Common Stock, par value $.01 per share 10/12/2005   M   977,971 A $ 2.42 6,210,898 D  
Common Stock, par value $.01 per share 10/12/2005   M   992,721 A $ 2.42 7,203,619 D  
Common Stock, par value $.01 per share 10/12/2005   M   130,247 A $ 3 7,333,866 D  
Common Stock, par value $.01 per share 10/12/2005   S   4,472,633 D $ 26.04 2,861,233 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Class C1A Stock Option $ 3 10/12/2005   M     946,419 10/12/2005(1) 08/26/2007 Common Stock (2) 946,419 $ 0 0 D  
Class C1A Stock Option $ 3.42 10/12/2005   M     403,000 10/12/2005(1) 08/26/2007 Common Stock (2) 403,000 $ 0 0 D  
Class C1B Stock Option $ 2.42 10/12/2005   M     2,423,892 10/12/2005(1) 08/26/2007 Common Stock (2) 2,423,892 $ 0 0 D  
Class C1B Stock Option $ 3 10/12/2005   M     344,263 10/12/2005(1) 08/26/2007 Common Stock (2) 344,263 $ 0 0 D  
Class C2 Stock Option $ 3 10/12/2005   M     156,903 10/12/2005(1) 08/26/2007 Common Stock (2) 156,903 $ 0 0 D  
Class C2 Stock Option $ 2.42 10/12/2005   M     110,351 10/12/2005(1) 08/26/2007 Common Stock (2) 110,351 $ 0 0 D  
Class C3 Stock Option $ 3 10/12/2005   M     848,099 10/12/2005(1) 08/26/2007 Common Stock (2) 848,099 $ 0 0 D  
Class C3 Stock Option $ 2.42 10/12/2005   M     977,971 10/12/2005(1) 08/26/2007 Common Stock (2) 977,971 $ 0 0 D  
Class C4 Stock Option $ 2.42 10/12/2005   M     992,721 10/12/2005(1) 08/26/2007 Common Stock (2) 992,721 $ 0 0 D  
Class C4 Stock Option $ 3 10/12/2005   M     130,247 10/12/2005(1) 08/26/2007 Common Stock (2) 130,247 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
AMMON CAROL A
100 PAINTERS DRIVE
CHADDS FORD, PA 19317		   X      

Signatures

 /s/ Carol A. Ammon   10/14/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The exercisability of the Stock Options was accelerated in connection with an offering of shares that closed on October 12, 2005.
(2) Common Stock held by Endo Pharma LLC. The exercise of these stock options did not result in the issuance of additional Common Stock by the Issuer.

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