Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
HIGHLAND CAPITAL MANAGEMENT LP
  2. Issuer Name and Ticker or Trading Symbol
COMPLETE GENOMICS INC [GNOM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O HIGHLAND CAPITAL MANAGEMENT, 13455 NOEL ROAD, 8TH FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
11/16/2010
(Street)

DALLAS, TX 75240
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $0.001 11/16/2010   C   465,596 A (1) 465,596 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   C   535,696 A (4) 1,001,292 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   C   563,018 A (4) 1,564,310 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   X   329,638 A $ 1.5 1,893,948 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   F   54,940 D $ 9 1,839,008 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   X   11,746 A $ 7.56 1,850,754 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   F   9,867 D $ 9 1,840,887 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   X   12,529 A $ 7.56 1,853,416 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   F   10,525 D $ 9 1,842,891 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   X   20,876 A $ 7.56 1,863,767 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   F   17,536 D $ 9 1,846,231 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   X   906 A $ 7.56 1,847,137 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   F   762 D $ 9 1,846,375 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   C   362,120 A (1) 362,120 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   C   52,969 A (4) 415,089 I See Footnotes (2) (3)
Common Stock, par value $0.001 11/16/2010   C   233,402 A (4) 648,491 I See Footnotes (2) (3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series C Preferred Stock (1) (1) 11/16/2010   C     465,596   (5)   (6) Common Stock 465,596 (1) 0 I See Footnotes (2) (3)
Series C Preferred Stock (1) (1) 11/16/2010   C     362,120   (5)   (6) Common Stock 362,120 (1) 0 I See Footnotes (2) (3)
Series D Preferred Stock (4) (4) 11/16/2010   C     535,696   (5)   (6) Common Stock 535,696 (4) 0 I See Footnotes (2) (3)
Series D Preferred Stock (4) (4) 11/16/2010   C     52,969   (5)   (6) Common Stock 52,969 (4) 0 I See Footnotes (2) (3)
Series E Preferred Stock (4) (4) 11/16/2010   C     563,018   (5)   (6) Common Stock 563,018 (4) 0 I See Footnotes (2) (3)
Series E Preferred Stock (4) (4) 11/16/2010   C     233,402   (5)   (6) Common Stock 233,402 (4) 0 I See Footnotes (2) (3)
Warrant to Purchase Common Stock $ 1.5 11/16/2010   X     329,638   (7) 08/12/2016 Common Stock 329,638 $ 0 0 I See Footnotes (2) (3)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     11,746   (7) 02/13/2014 Common Stock 11,746 $ 0 0 I See Footnotes (2) (3)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     12,529   (7) 04/06/2014 Common Stock 12,529 $ 0 0 I See Footnotes (2) (3)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     20,876   (7) 06/12/2014 Common Stock 20,876 $ 0 0 I See Footnotes (2) (3)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     906   (7) 08/05/2014 Common Stock 906 $ 0 0 I See Footnotes (2) (3)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
HIGHLAND CAPITAL MANAGEMENT LP
C/O HIGHLAND CAPITAL MANAGEMENT
13455 NOEL ROAD, 8TH FLOOR
DALLAS, TX 75240
    X    
Strand Advisors, Inc.
13455 NOEL ROAD
SUITE 800
DALLAS, TX 75240
    X    
DONDERO JAMES D
13455 NOEL ROAD, STE 1300
DALLAS, TX 75240
    X    

Signatures

 /s/ James D. Dondero for Highland Capital Management, L.P.   11/16/2010
**Signature of Reporting Person Date

 /s/ James D. Dondero for Strand Advisors, Inc.   11/16/2010
**Signature of Reporting Person Date

 /s/ James D. Dondero   11/16/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each share of Series C Preferred Stock was automatically converted into common stock immediately prior to the completion of the Issuer's initial public offering. Shares are reported on an "as converted" basis giving effect to the 8.241076 conversion ratio applicable to such shares.
(2) This statement is jointly filed by and on behalf of each of Highland Capital Management, L.P., Strand Advisors, Inc., and James D. Dondero. Highland acts as an investment adviser to, and manages investment and trading accounts of, other persons and may be deemed, through investment advisory contracts or otherwise, to beneficially own securities owned by other persons. Strand Advisors is the general partner of Highland and may be deemed to beneficially own securities owned by Highland. Mr. Dondero is the President and a director of Strand Advisors and may be deemed to beneficially own securities owned by Strand Advisors.
(3) Each reporting person states that neither the filing of this statement nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Act or otherwise, the beneficial owners of any securities covered by this statement. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.
(4) Each share of Series D and Series E Preferred Stock will automatically convert on a 1 for 1 basis into common stock upon the closing of the Issuer's initial public offering.
(5) The securities are immediately convertible.
(6) The expiration date is not relevant to the conversion of these securities.
(7) The warrant is immediately exercisable.

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