FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * SENYEI ANDREW E   2. Issuer Name and Ticker or Trading Symbol COMPLETE GENOMICS INC [GNOM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O ENTERPRISE PARTNERS, 2223 AVENIDA DE LA PLAYA, SUITE 300 3. Date of Earliest Transaction (Month/Day/Year) 11/16/2010 (Street) LA JOLLA, CA 92037-3218 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, par value $0.001 11/16/2010   C   66,138 A (5) 66,138 I See Footnote (6) Common Stock, par value $0.001 11/16/2010   C   27,049 A (5) 101,043 I See Footnote (6) Common Stock, par value $0.001 11/16/2010   C   176,737 A (5) 176,737 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   C   259,458 A (5) 436,195 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   X   138,794 A $ 7.56 574,989 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   F   23,133 D $ 9 551,856 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   X   17,261 A $ 7.56 569,117 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   F   14,500 D $ 9 554,617 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   X   8,378 A $ 7.56 562,995 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   F   7,038 D $ 9 555,957 I See Footnote (7) Common Stock, par value $0.001 11/16/2010   P(8)   111,111 A $ 9 667,068 I See Footnote (7)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Warrant to Purchase Series D Preferred Stock (5)

$ 7.56

11/16/2010

X

17,261

(10)

04/06/2014

Common Stock

17,261

$ 0

0

I

See Footnote (7)

Warrant to Purchase Series D Preferred Stock (5)

$ 7.56

11/16/2010

X

2,958

(10)

06/12/2014

Common Stock

2,958

$ 0

0

I

See Footnote (2)

Warrant to Purchase Series D Preferred Stock (5)

$ 7.56

11/16/2010

X

8,378

(10)

06/12/2014

Common Stock

8,378

$ 0

0

I

See Footnote (7)

Warrant to Purchase Series D Preferred Stock (5)

$ 7.56

11/16/2010

X

1,096

(10)

08/05/2014

Common Stock

1,096

$ 0

0

I

See Footnote (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SENYEI ANDREW E C/O ENTERPRISE PARTNERS 2223 AVENIDA DE LA PLAYA, SUITE 300 LA JOLLA, CA 92037-3218	X	X

Signatures

/s/ Andrew E. Senyei		11/16/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(2)	The shares are owned by Enterprise Partners VI, LP ("Enterprise VI"). Enterprise Management Partners VI, LLC ("Enterprise VI LLC") serves as the general partner of Enterprise VI. Andrew E. Senyei, M.D. is a managing director of Enterprise VI LLC and shares voting and investment power over the shares held by Enterprise VI. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein.
(5)	Each share of Series D and Series E Preferred Stock was automatically converted into one share of Common Stock immediately prior to the completion of the Issuer's initial public offering.
(6)	The shares are owned by Enterprise Partners Management, LLC ("Enterprise LLC"). Andrew E. Senyei, M.D. is a managing director of Enterprise LLC and shares voting and investment power over the shares held by Enterprise LLC. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein.
(7)	The shares are owned by Enterprise Partners V, LP ("Enterprise V"). Enterprise Management Partners V, LLC ("Enterprise V LLC") serves as the general partner of Enterprise V. Andrew E. Senyei, M.D. is a managing director of Enterprise V LLC and shares voting and investment power over the shares held by Enterprise V. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein.
(8)	The securities are immediately convertible.
(10)	The warrant is immediately exercisable.
Remarks: Form 2 of 2

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