As filed pursuant to Rule 424(b)(3) Registration No. 333-109584 Prospectus Supplement No. 2 (To Prospectus dated November 3, 2003) AXONYX INC. 14,479,355 shares of common stock This Prospectus Supplement No. 2 supplements and amends the Prospectus dated November 3, 2003 (the "Prospectus") that covers the offer and sale of up to 14,479,355 shares of common stock of Axonyx Inc. from time to time by certain selling security holders named in the Prospectus. The table on pages 19 through 21 of the Prospectus sets forth information with respect to the selling security holders (as defined in the Prospectus) and the respective amounts of shares of common stock beneficially owned by each selling security holder that may be offered pursuant the Prospectus. This Prospectus Supplement amends and restates that table by adding the remaining items set forth below to that table. Shares Owned Prior to Shares Available this Offering Pursuant to this Shares Owned After Selling Security Holder Prospectus Offering ----------------------- --------------------- ---------------- -------- Rodman & Renshaw, Inc. 265,712 265,712 0 Smithfield Fiduciary LLC 841,122 841,122 0 ----------------------------------- The Prospectus, together with this Prospectus Supplement No. 2, constitutes the prospectus required to be delivered by Section 5(b) of the Securities Act of 1933, as amended, with respect to offers and sales of the Common Stock. The common stock offered involves a high degree of risk. See the "Risk Factors" section commencing on page 7 of the accompanying prospectus for a discussion of some important risks you should consider before buying any shares of common stock. ----------------------------------- Neither the Securities and Exchange Commission, nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense. ----------------------------------- The date of this Prospectus Supplement is December 22, 2003 SELLING SECURITY HOLDERS The following table sets forth, as of December 22, 2003, the name of each selling security holder, the number of shares of common stock beneficially owned by the selling security holder as of the date of this prospectus, the maximum number of shares of common stock being offered by each of them in this offering and the number of shares of common stock to be owned by the selling security holder after this offering (assuming sale of such maximum number of shares). The information contained in the following table is derived from our books and records, as well as from our transfer agent and the selling security holders. The following table assumes the sale of all shares included in this prospectus. Shares Owned Prior to Shares Available this Offering Pursuant to this Shares Owned After Selling Security Holder Prospectus Offering ----------------------- ---------------------- ---------- -------- AIG DKR Soundshore Strategic Holding Fund Ltd. 130,841 130,841 0 Alpha Capital AG 130,841 130,841 0 Ascend Offshore Fund Ltd. 43,200 43,200 0 Ascend Partners, L.P. 9,394 9,394 0 Ascend Partners Sapient, L.P. 9,906 9,906 0 BayStar Capital II, LP 598,131 598,131 0 Behrens, Karsten 40,000 40,000 0 Berkin Business SA 10,000 10,000 0 Blue Coast Partners, L.P. 22,195 7,895 14,300 Blue Coast Partners II, L.P. 57,381 13,470 43,911 Bristol Investment Fund, Ltd 261,683 261,683 0 Caduceus Capital II, L.P. 332,675 332,675 0 Citi Fort Point Ltd. 5,975 5,975 0 Clarion Capital Corporation 452,401 130,841 321,560 Columbia Marketing Ltd. 20,000 20,000 0 Cranshire Capital, L.P. 295,657 295,657 0 Crescent International Ltd. 175,000 175,000 0 Delta Opportunity Fund (Institutional), LLC 104,673 104,673 0 Delta Opportunity Fund, Ltd. 157,010 157,010 0 DiFalco, Nicholas 50,750 50,750 0 Galleon Healthcare Offshore, Ltd. 1,675,750 1,505,000 170,750 Galleon Healthcare Partners, LP 274,350 245,000 29,350 Green Coast Offshore Ltd. 62,714 19,225 43,489 HFR SHC Aggressive Master Trust 22,400 22,400 0 Hoefliger, Heinz 120,000 120,000 0 JSW Research 80,000 80,000 0 Julios Trust 26,167 26,167 0 Katie and Adam Bridge Partners L.P. 26,167 26,167 0 KCM Biomedical L.P. 1,665,210 176,500 1,488,710 KCM Biomedical II L.P. 99,900 7,000 92,900 KCM Biomedical Offshore Fund 498,250 55,750 442,500 Langley Partners, L.P. 130,841 130,841 0 M.D.K. Foundation, Inc. 52,500 52,500 0 MSS Descendants Trust 26,167 26,167 0 Multi-National Consulting Services, IV, LLC 20,933 20,933 0 Omicron Master Trust 523,364 523,364 0 OTAPE Investments LLC 146,542 146,542 0 Panacea Fund, LLC 210,000 210,000 0 Perceptive Life Sciences Master Fund, Ltd 1,872,077 1,084,227 787,850 Portside Growth and Opportunity Fund (1) 261,683 261,683 0 Promed Offshore Fund, Ltd. 38,388 38,388 0 Promed Partners. L.P. 223,300 223,300 0 Punk Ziegel & Co. (2) 280,982 280,982 0 Quogue Capital, LLC 783,750 533,750 250,000 Rodman & Renshaw, Inc. (3) 265,712 265,712 0 Rothbaum, Wayne 15,000 15,000 0 Royal Bank of Canada 448,598 448,598 0 Sands Brothers Venture Capital LLC 52,335 52,335 0 Sands Brothers Venture Capital II LLC 52,335 52,335 0 Sands Brothers Venture Capital III LLC 523,364 523,364 0 Sands Brothers Venture Capital IV LLC 157,008 157,008 0 SB Opportunity Institution Associates LLC 65,420 65,420 0 Seringer, Kellie 22,500 7,500 15,000 SF Capital Partners Ltd. 261,683 261,683 0 Smithfield Fiduciary LLC 841,122 841,122 0 Special Situations Private Equity Fund, L.P. 785,047 785,047 0 Spectra Capital Management 261,683 261,683 0 Symmetry Capital 187,650 5,000 182,650 TCMP3 Partners 78,505 78,505 0 The Tail Wind Fund Limited 261,683 261,683 0 UBS Eucalyptus Fund, LLC 718,550 718,550 0 UBS Eucalyptus Fund, Ltd. 104,825 104,825 0 Wider, Jedd 323,750 323,750 0 Winchester Global Trust Company Limited as Trustee for Caduceus Capital Trust 653,324 653,324 0 Wolfe Axelrod Weinberger Associates LLC 150,000 150,000 0 280 Ventures LLC 13,083 13,083 0 4P Management Partners S.A. 90,000 90,000 0