SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                (RULE 13d - 102)

      INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b),
            (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d

                               (Amendment No. 1)*
        AnorMED Inc.
------------------------------
(Name of Issuer)

        Common Stock
------------------------------
(Title of Class of Securities)

        035910108
------------------------------
(CUSIP Number)

        September 15, 2006
------------------------------
(Date of Event which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]  Rule 13d-1(b)
[x]  Rule 13d-1(c)
[ ]  Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





1. NAMES OF REPORTING PERSONS
   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Amaranth LLC

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x]
         (b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

          Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5. SOLE VOTING POWER

           0

6. SHARED VOTING POWER

           0
        -------------

7. SOLE DISPOSITIVE POWER

           0

8. SHARED DISPOSITIVE POWER

           0
        -------------

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           See 6 and 8 above.

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
    EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0%
        -------------

12. TYPE OF REPORTING PERSON*

           CO






1. NAMES OF REPORTING PERSONS
   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Amaranth Global Equities Master Fund Limited

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x]
         (b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

          Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5. SOLE VOTING POWER

          0

6. SHARED VOTING POWER

          0
        -------------

7. SOLE DISPOSITIVE POWER

          0

8. SHARED DISPOSITIVE POWER

          0
        -------------

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          See 6 and 8 above.

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
    EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

          0%
        -------------

12. TYPE OF REPORTING PERSON*

         CO


1. NAMES OF REPORTING PERSONS
   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Amaranth Advisors L.L.C.

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x]
         (b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

         StateDelaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5. SOLE VOTING POWER

         0

6. SHARED VOTING POWER

         0
        -------------

7. SOLE DISPOSITIVE POWER

         0

8. SHARED DISPOSITIVE POWER

         0
        -------------

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         See 6 and 8 above.

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
    EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         0%
        -------------

12. TYPE OF REPORTING PERSON*

         IA





1. NAMES OF REPORTING PERSONS
   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Nicholas M. Maounis

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x]
         (b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

          United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5. SOLE VOTING POWER

          0

6. SHARED VOTING POWER

          0
        -------------

7. SOLE DISPOSITIVE POWER

          0

8. SHARED DISPOSITIVE POWER

          0
        -------------

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          See 6 and 8 above.

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
    EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

          0%
        -------------

12. TYPE OF REPORTING PERSON*

          IN, HC


This  statement is filed with respect to the shares of common  stock,  having no
par value (the "Common Stock") of AnorMED Inc. (the "Issuer") beneficially owned
by Amaranth LLC  ("Amaranth")  and Amaranth  Global Equities Master Fund Limited
("Global"), both Cayman Islands exempted companies, Amaranth Advisors L.L.C. and
Nicholas M. Maounis  (collectively,  the  "Reporting  Persons") as of October 5,
2006 and  amends  and  supplements  the  Schedule  13G filed  March 8, 2006 (the
"Schedule 13G"). Except as set forth herein, the Schedule 13G is unmodified

Item 4.   Ownership.

Provide the following  information regarding the aggregate number and percentage
of the class of securities of the issuer identified in Item 1.

     (a)  Amaranth beneficially owns 0 shares of the issuers Common Stock.

          Global beneficially owns 0 shares of the issuers Common Stock.

          Amaranth  Advisors L.L.C may be deemed to beneficially  own the shares
          of Common  Stock held by Amaranth  and Global as a result of being the
          Trading Advisor of Amaranth and Global.

          Mr.  Maounis  may be deemed to  beneficially  own the shares of Common
          Stock held by  Amaranth  and Global as a result of being the  managing
          member of Amaranth Advisors L.L.C.

     (b)  Amaranth's  beneficial  ownership of 0 shares of the  Issuer's  Common
          Stock represents 0 % of the total common stock outstanding.

          Global's beneficial ownership of 0 shares of the Issuer's Common Stock
          represents 0% of the total common stock outstanding.

          Collectively,  the  Reporting  Persons  beneficially  own 0 shares  of
          Common Stock which represent 0% of the Common Stock outstanding.


Item 5.   Ownership of Five Percent or Less of a Class.

          If this  statement  is being  filed to report  the fact that as of the
          date hereof the  Reporting  Persons  have ceased to be the  beneficial
          owner of more than five percent of the class of securities,  check the
          following [X].

Item 10.  Certification.

          By signing below the  undersigned  certifies  that, to the best of its
          knowledge  and  belief,  the  securities  referred  to above  were not
          acquired  and are not held for the  purpose  of or with the  effect of
          changing or  influencing  the control of the issuer of the  securities
          and were not  acquired  and are not  held in  connection  with or as a
          participant in any transaction having that purpose or effect.








                                              SIGNATURES

     After reasonable inquiry and to the best of its knowledge and belief,  each
of the undersigned  certifies that the information  with respect to it set forth
in this statement is true, complete, and correct.


Dated:   October 5, 2006
         ---------------

          AMARANTH LLC,
                   by Amaranth Advisors L.L.C., as Trading Advisor

                   By: /s/Nicholas M. Maounis, Managing Member
                       ----------------------------------------
                          Nicholas M. Maounis, Managing Member

          AMARANTH GLOBAL EQUITIES MASTER FUND LIMITED,
                   by Amaranth Advisors L.L.C., as Trading Advisor

                   By: /s/Nicholas M. Maounis, Managing Member
                       ----------------------------------------
                          Nicholas M. Maounis, Managing Member


          AMARANTH ADVISORS L.L.C.

                   By: /s/Nicholas M. Maounis, Managing Member
                       ----------------------------------------
                          Nicholas M. Maounis, Managing Member


          NICHOLAS M. MAOUNIS


                       /s/Nicholas M. Maounis
                       ----------------------
                          Nicholas M. Maounis