U.S. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940 [_] Check box if no longer subject of Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). (Print or Type Responses) ------------------------------------------------------------------------------ 1. Name and Address of Reporting Person* Carter William A. ------------------------------------------------------------------------------ (Last) (First) (Middle) 1617 JFK Boulevard ------------------------------------------------------------------------------ (Street) Philadelphia PA 19103 ------------------------------------------------------------------------------ (City) (State) (Zip) ----------------------------------------------------------------------------- 2. Issuer Name and Ticker or Trading Symbol Hemispherx Biopharma, Inc. 36: ---------------------------------------------------------------------------- 3. IRS Identification Number of Reporting Person, if an Entity (Voluntary) 40: ---------------------------------------------------------------------------- 4. Statement for Month/Day/Year 04/24/03 44:---------------------------------------------------------------------------- 5. If Amendment, Date of Original (Month/Year) ================================================================================ 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) [x] Director [x] 10% Owner [x] Officer (give title below) [_] Other (specify below) CEO and Chairman 55: ---------------------------------------------------------------------------- 7. Individual or Joint/Group Filing (Check Applicable Line) [x] Form filed by one Reporting Person [_] Form filed by more Than One Reporting Person 59: ---------------------------------------------------------------------------- ================================================================================ Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ================================================================================ 6. 4. 5. Owner- Securities Acquired (A) or Amount of ship 3. Disposed of (D) Securities Form: 7. Transaction (Instr. 3, 4 and 5) Beneficially Direct Nature of 2. Code ------------------------------- Owned at End (D) or Indirect 1. Transaction (Instr. 8) (A) of Month Indirect Beneficial Title of Security Date ------------ Amount or Price (Instr. 3 (I) Ownership (Instr. 3) (Month/Day/Year) Code V (D) and 4) (Instr.4) (Instr. 4) ---------------------------------------------------------------------------------------------------------------------------------- Common stock 04/24/03 G 10,000 D 810,090 D ---------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------- ==================================================================================================================================== Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. *If the form is filed by more than one reporting person, see Instruction 4(b)(v) (Over) SEC 1474 (3-99) FORM 4 (continued) Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) ================================================================================ 10. 9. Owner- Number ship of Form 2. Deriv- of Conver- 5. 7. ative Deriv- 11. sion Number of Title and Amount Secur- ative Nature or Derivative 6. of Underlying 8. ities Secur- of Exer- 4. Securities Date Securities Price Bene- ity In- cise 3. 3A Trans- Acquired (A) Exercisable and (Instr. 3 and 4) of ficially Direct direct Price Trans- Deemed action or Disposed Expiration Date ---------------- Deriv- Owned (D) or Bene- 1. of action Execution Code of(D) (Month/Day/Year) Amount ative at End In- ficial Title of Deriv- Date date (Instr. (Instr. 3, ---------------- or Secur- of direct Owner- Derivative ative (Month/ If any 8) 4 and 5) Date Expira- Number ity Month (I) ship Security Secur- Day/ ------ ------------ Exer- tion of (Instr. (Instr. (Instr. (Instr. (Instr. 3) ity Year) Code V (A) (D) cisable Date Title Shares 5) 4) 4) 4) ---------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------- ==================================================================================================================================== Explanation of Responses: /s/ William A. Carter --------------------------------------------- **Signature of Reporting Person Date 04-24-2003 ----------------------------------------- ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.